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| 1 | Oral polymorphonuclear neutrophil characteristics in relation to oral health: a cross-sectional, observational clinical study显示文摘Polymorphonuclear neutrophils(PMNs) have a major role in the innate immune system. However, little is known about PMN contribution in relation to oral health. The objective of this study was to investigate the numbers and functional characteristics of oral PMNs(o PMNs) compared with circulatory PMNs(c PMNs). Oral rinse and venous blood samples were obtained from 268 systemically and orally healthy volunteers in a cross-sectional observational study. PMN counts, cell cycle analysis and cellular activation state were investigated. Also, reactive oxygen species(ROS) production was analyzed, with and without bacterial stimulation(Fusobacterium nucleatum). In males, 1.2 × 10~6± 1.0 × 10~6 oPMNs were collected, and showed a tendency to correlate with the levels of gingival bleeding(r = 0.215, P = 0.008). Comparable o PMNs counts were found among females(1.0 × 10~6± 0.7 × 10~6). More late-stage apoptotic/necrotic cells were found among the o PMNs(53.1%) compared with the c PMNs(8.5%; Po0.001). Without additional stimulation, o PMNs were more activated than c PMNs, as indicated by higher expression of CD11 b, CD63 and CD66 b, and higher constitutive ROS levels(Po0.001). Notably, in response to bacterial stimulation, o PMNs released comparable ROS levels as c PMNs(P = 0.042). In conclusion, this study provides data on viable o PMNs showing high levels of activation in orally and systemically healthy individuals, free of apparent caries lesions and periodontal disease. These data suggests that although the o PMNs are in a more mature stage of their life cycle compared with the c PMNs, o PMNs are still responsive to stimulation, which indicates their functional potential and possible contribution to a healthy oral ecosystem. | Patrick Rijkschroeff Ineke DC Jansen Fridus A van der Weijden Bart IF Keijser Bruno G Loos Elena A Nicu | 2016 | International Journal of Oral Science2016，8，3： | 2 |
| 2 | The site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology显示文摘 | Van der Wal AC Becker AE van der Loos CM | 1994 | Circulation1994，89，： | 1 |
| 3 | Costimulatory molecules in human atherosclerotic plaques: an indication of antigen specific T lymphocyte activation显示文摘 | Onno J de Boer Floris Hirsch Allard C van der Wal Chris M van der Loos Pranab K Das Anton E Becker | 1997 | Atherosclerosis1997，，2： | 1 |
| 4 | Enhanced peroxynitrite formation is associated with vascular aging显示文摘 | van der Loo B Labugger R Skepper JN | | 0，，12： | 1 |
| 5 | Porphyromonas gingivalis,Bacteroides forsythus and other putative periodontal pathogens in subjects with and without periodontal destruction显示文摘 | van Winkelhoff AJ Loos BG van der Reijden WA | 2002 | J Clin Periodontal2002，29，11： | 1 |
| 6 | Site of intimal rupture or erosion of thrombosed coronary atherosderotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology显示文摘 | van der Wal AC Becker AE van der Loos CM | 1994 | Circulation1994，89，1： | 1 |
| 7 | Inactivity of nitric oxide synthase gene in the atherosclerotic human carotid artery显示文摘 | Tanner FC van der Loo B Shaw S | 2007 | Basic Res Cardiol2007，102，4： | 1 |
| 8 | C-reactive protein and red cell aggregation correlate with late venous function after acute deep venous thrombosis显示文摘 | Elisabeth Krieger Bernd van Der Loo Beatrice R | 2004 | J Vasc Surg2004，40，4： | 1 |
| 9 | Por- phyromonas gingivalis, bacteroides forsythus and other putative periodontal pathogens in subjects with and without periodontal destruction显示文摘 | van Winkelhoff AJ Loos BG van der Reijden WA | 2002 | J Clin Periodontol2002，29，11： | 1 |
| 10 | Diversity and evolutionary history of the MHC DQA gene in leporids 显示文摘 | Surridge A van der Loo W Abrantes J | 2008 | Immunogenetics2008，60，： | 1 |
| 11 | Monocyte - derived RANTES in intrinsically elevated in periodontal disease while MCP - 1 levels are related to inflammation and are inversely correlated with IL - 12 levels显示文摘 | Fokkema SJ Loos BG van der Velden U | 2003 | Clin Exp Immunol2003，131，3： | 1 |
| 12 | Adventitial infiltrated associated with advanced atherosclerotic plaques: structural organization suggests generation of local humoral immune responses显示文摘 | Houtkamp MA de Boer OJ van der Loos CM | 2001 | The journal of pathology2001，193，2： | 1 |
| 13 | C-reactive protein and red cell aggregation correlate with late venous function after acute deep venous thrombosis显示文摘 | Krieger E van Der Loo B Amann-Vesti BR | 2004 | J Vasc Surg2004，40，4： | 1 |
| 14 | Mast cell infiltration in acute coronarysyndromes: implications for plaque rupture 显示文摘 | Kartinen M van der Wal AC van der Loos CM | 1998 | J Am Coll Cardiol1998，32，3： | 1 |
| 15 | Isotated ven tricular noncompaction of the myocardium in adults显示文摘 | Jenni R Oechalin van der Loo B | 2007 | Heart2007，93，1： | 1 |
| 16 | Mast cell infiltration in acute coronary syndromes:implications for plaque rupture显示文摘 | Kaartinen M van der Wal AC van der Loos CM | 1998 | J Am Coll Cardiol1998，32，： | 1 |
| 17 | Mitochondrial impairment observed in fibroblasts from South African Parkinson's disease pa- tiants with parkin mutations 显示文摘 | Van der Merwe C Loos B Swart C | 2014 | Biochem Biophys Res Commun2014，447，2： | 1 |
| 18 | Porphyromonas gingivalis,Bacteroides forsythus and other putative periodontal pathogens in subjects with and without periodontal destruction显示文摘 | van Winkelhoff AJ Loos BG van der Reijden WA | 2002 | J Clin Periodontol2002，29，11： | 1 |
| 19 | Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology显示文摘 | Van der Wal AC Becker AE Van tier Loos CM | 1994 | Circulation1994，89，1： | 1 |
| 20 | Analysis of thick brain sections by obverse-reverse computer microscopy:application of a new,high clarity Golgi-Nissl stain显示文摘 | Glaser EM Van der Loos H | | 0，，2： | 1 |
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