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| 1 | Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients显示文摘AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci. | Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh | 2010 | World Journal of Gastroenterology2010，16，2： | 2 |
| 2 | Antioxidant and free radical scavenging activities of 5,7,3'-trihydroxy-3,6,4'-trimethoxyflavone from Brickellia veronicaefolia 显示文摘 | PF REZ G R M VARGAS S R MARTINEZ M F J | 2004 | Phytother Res2004，18，5： | 1 |
| 3 | Dollar spot resistance to DMI fungicides显示文摘 | Vargas J M Golembiewski R C Detweiler A R | 1992 | Golf Course Management1992，60，3： | 1 |
| 4 | Reduction of humic substances and Fe (Ⅲ ) by hyperthermophilic microorganisms 显示文摘 | LOVLEY D R KASHEFI K VARGAS M | 2000 | Chemical Geology2000，169，9： | 1 |
| 5 | Long-term clinical efficacy of grass-pollen immunotherapy显示文摘 | DURHAM S R WALKER S M VARGA E M | 1999 | N Engl J Med1999，34，1： | 1 |
| 6 | Long-term clinical effeacy of grass-pollen immunotherapy显示文摘 | DURHAM S R WALKER S M VARGA E M | 1999 | N Engl Med1999，341，： | 1 |
| 7 | Platelets stimulate prolifera- tion of bone cells: involvement of platelet-derived growth factor, mi- croparticles and membranes 显示文摘 | Gruber R Varga F Fischer M B | 2002 | Clinical Oral Implants Research2002，13，5： | 1 |
| 8 | MDCT in pancreatic adenocarcinoma: prediction of vascular invasion and respectability using a mutiphase technique with curved planar reformation 显示文摘 | Vargas R Nino- Murcia M Trueblood W | 2004 | AJR2004，182，2： | 1 |
| 9 | The role of tau in Alzheimer's disease and related disorders 显示文摘 | Medeiros R Baglietto Vargas D LaFerla F M | 2011 | CNS neuroscience & therapeutics2011，17，5： | 1 |
| 10 | T3 affects expression of collagen I and collagen cross-linking in bone cell cultures显示文摘 | Varga F Rumpler M Zoehrer R Turecek C Spitzer S Thaler R Paschalis EP Klaushofer K | | 0，，： | 1 |
| 11 | Acceleration of relaxation methods for non-Hermitian linear systems 显示文摘 | Eiermann M Niethammer W Varga R S | 1992 | Siam J Matrix Anal1992，13，3： | 1 |
| 12 | Cholecystokinins suppresses food intake by a noendocrine mechanism in rats显示文摘 | Reidelberger R D Varga R M Liehr D A | 1994 | Am J Physiol1994，267，： | 1 |
| 13 | Comparative demography of six fruit fly (Diptera: Tephritidae) parasitoids (Hymenoptera: Braconidae)显示文摘 | Vargas R I Ramadan M Hussain T | 2002 | Biological Control2002，25，： | 1 |
| 14 | Long term clinical efficacy of grass-pollen immunotherapy显示文摘 | DURHAM S R WALKER S M VARGA E M | 1999 | N Engl J Med1999，341，： | 1 |
| 15 | Inter-annual Variability of the Cuyo Ivers' Streamflow in the Argentinean Andean Mountains and ENSO Events显示文摘 | Compagnucci R H Vargas W M | 1998 | International Journal of Climatology1998，18，： | 1 |
| 16 | Methyl eugenol and cue lure traps for suppression of male oriental fruit flies and melon flies ( Diptera : Tephritidae) in Hawaii: effects of lure mixtures and weathering显示文摘 | Vargas R I Stark J D Kido M D | 2000 | J Econ Entomol2000，93，3： | 1 |
| 17 | MDCT in pancreatic adenocarcinoma:prediction of vascular invasion and resectability using a multiphasic technique with curved planar reformations显示文摘 | Vargas R Nino-Murcia M Trueblood W | 2004 | AJR2004，182，2： | 1 |
| 18 | Mixed-effects modelling of time series NDVI-rainfall relationship for detecting human-induced loss of vegetation cover in drylands显示文摘 | Omuto C T Vargas R R Alim M S | 2010 | Journal of Arid Environments2010，74，11： | 1 |
| 19 | Transesterification of soybean oil catalyzed by alkylguanidines heterogenized on different substituted polystyenes显示文摘 | SCHUCHARDT U VARGAS R M GELBARD G | 1996 | Journal of Molecular Catalysis A:Chemical1996，109，1： | 1 |
| 20 | MDCT in pancreatic adenocarcinoma prediction of vascular jnvasion and resectability using a multiphasic technique with curved planar refomations显示文摘 | Vargas R Ninc-Murcia M Trueblood W | 2004 | AJR2004，182，： | 1 |
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