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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Extended lymph node dissection for gastric cancer:who may benefit?Final results of the randomized Dutch gastric cancer group trial显示文摘 | Hartgrink HH van de Velde C J Putter H | | 0，，11： | 3 |
| 3 | Extended lymph node dissection for gastric cancer:who may benefit? Final results of the randomized Dutch gastric cancer group trial显示文摘 | Hartgrink HH van de Velde C J Putter H | 2004 | J Clini On- col2004，22，11： | 1 |
| 4 | Preoperative chemotherapy in primary operable breast cancer: results from the European Organization for Research and Treat- ment of Cancer trial 10902 显示文摘 | van der HAGE J A van de VELDE C J H JULIEN J P | 2001 | J Clin Oneol2001，19，22： | 1 |
| 5 | Micrometastasis and survival in stage Ⅱ colorectal cancer显示文摘 | Leifers G J Cleton Jansen A M Van de Velde C J H | 1998 | N Engl J Med1998，339，4： | 1 |
| 6 | The effects of extreme water level fluctuations on the wetland vegetation of a nymphaeid-dominated oxbow lake in The Netberlands显示文摘 | BROCK T C M VELDE VAN DER G STEEG VAN DE H M | 1987 | Arch Hydrobiologia1987，，27： | 1 |
| 7 | C-statistics versuslogistic regression for assessing the performance of qualitativediagnostic tests显示文摘 | Romero C Te Velde L Ponsen H | 2012 | Clin Chem Lab Med2012，50，1： | 1 |
| 8 | 查看详情显示文摘 | Fox D J Velde H T Preza C O'Sullivan J A Smith W H Woolsey T A | | 0，，： | 1 |
| 9 | Effect of gel texture and sucrose spatial distribution on sweetness perception显示文摘 | MOSCA A C VELDE F BULT J H F | | 0，，01： | 1 |
| 10 | Status of extended lymph node dissection:locoregional control is the only way to survive gastric cancer显示文摘 | Hartgrink H H van de Velde C J | 2005 | J Surg Oncol2005，90，3： | 1 |
| 11 | Extended lymph node dissection for gastric cancer, who may benefit? Final results of the ran- domized Dutch gastric cancer group trial显示文摘 | Hartgrink HH van de Velde C J Putter H | 2004 | J Clin Oncol2004，22，11： | 1 |
| 12 | Status of extended lymph node dissection: Eocoregional control is the only way to survive gastric cancer显示文摘 | HARTGRINK H H van de VELDE C J | 2005 | J Surg Oncol2005，90，3： | 1 |
| 13 | Scheduling a batching machine显示文摘 | Brucker P Gladky A Hoogeveen H Kovalyov M Y Potts C N Tautenhahn T van de Velde S L | 1998 | Journal of Scheduling1998，1，： | 1 |
| 14 | Scheduling a batching machine显示文摘 | Brucker P Gladky A Potts C N Hoogeveen H Kovalyov M Y Tartenhahn T Van Ce Velde S L | 1998 | Journal of Scheduling1998，1，： | 1 |
| 15 | C-statistics versus logistic regression for assessing the performance of qualitative diagnostic tests 显示文摘 | Romero C te Velde L Ponsen H | 2012 | Clin Chem Lab Med2012，50，1： | 1 |
| 16 | Extended lymph node dissection for gastric cancer: who may benefit? Final results of the randomizeddutch gastric cancer group trial 显示文摘 | Hartgrink HH van de Velde C J Putter H | 2004 | J Clin Onco12004，22，11： | 1 |
| 17 | Impact of short-term preoperative radiotherapy on health-related quality of life and sexual functioning in primary rectal cancer: report of a multicenter randomized trial 显示文摘 | Marijnen CA van de Velde C J Putter H | 2005 | Clin Oncol2005，23，： | 1 |
| 18 | Scheduling a batching machine显示文摘 | Brucker P Gladky A Hoogeveen H Kovalyov M Y Potts C N Tautenhahn T Van de Velde S L | 1998 | Journal of Scheduilng1998，1，： | 1 |
| 19 | Significance of K-Ar ages of authigenic illitic clay-minerals in sandstones and shales from the North-sea显示文摘 | Matthews J C Velde B Johansen H | 1994 | Clay Miner1994，29，3： | 1 |
| 20 | Ex- tended lymph node dissection from gastric cancer: who may benefit? Final results of the randomized Dutch Gastric Cancer Group Trim 显示文摘 | HARTGRINK H H VAN DE VELDE C J PUTIER H | 2004 | J Clin Oncol2004，22，11： | 1 |
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