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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Preparation of esters of gallic acid with higher primary alcohols 显示文摘 | KERK G J M van der VERBEEK J H CLETON J C F | 1951 | Rec Tray Chim1951，70，： | 1 |
| 3 | Reduction rules for YAWL workflows with cancellation regions and OR-joins显示文摘 | Wynn M T Verbeek H M W van der Aalst W M P | 2009 | Information and Software Technology2009，51，6： | 1 |
| 4 | A GroEL homologue from endosymbiotic bacteria of the whitefly Bemisia tabaci is implicated in the circulative transmission of tomato yellow leaf curl virus显示文摘 | Morin S Gottlieb Y Zeidan M Czosnek H Verbeek M van den Heuvel J F J M | | 0，，： | 1 |
| 5 | Process mining:a two-step approach to balance between underfitting and overfitting显示文摘 | Van der AALST W M P RUBIN V VERBEEK H M W | 2010 | Software and Systems Modeling2010，9，1： | 1 |
| 6 | Soundness-preserving reduction rules for reset workflow nets显示文摘 | Wynn M T Verbeek H M W van der Aalst W M P | 2009 | Information Sciences2009，179，6： | 1 |
| 7 | Diagnosing Workflow Process Using Woflan显示文摘 | Verbeek H M W | 2001 | Computer Journal2001，44，4： | 1 |
| 8 | Diagnosing workflow processes using Woflan显示文摘 | Verbeek H M W Basten T Van Der Aalst W M P | 2001 | The Computer Journal2001，44，4： | 1 |
| 9 | Solubility of synthetic calcium hydroxyapatites 显示文摘 | Verbeek RMH Steyear H Thun HP | 1980 | J Chem Soc Faraday I1980，76，2： | 1 |
| 10 | The secondary FLT3-ITD F691L mutation induces resistance to AC220 in FLT3-ITD+ AML but retains in vitro sensitivity to PKC412 and Sunitinib显示文摘 | Albers C Leischner H Verbeek M | 2013 | Leukemia2013，27，6： | 1 |
| 11 | Risk factors for ulnar nerve compression at the elbow:a case control study显示文摘 | Bartels R H Verbeek A L | | 0，，07： | 1 |
| 12 | The double explosive layer cylindrical compaction method 显示文摘 | Stuivinga M Verbeek H J Carton E P | 1999 | Journal of Materials Processing Technology1999，85，： | 1 |
| 13 | Development and evaluation of a quality assessment instrument for occupational physicians显示文摘 | Van der Weide W E Verbeek J Van Dijk F J H | 1998 | Occupational and Environmental Medicine1998，55，6： | 1 |
| 14 | Relia bility and Validity of Instruments Measuring Job Satisfaction a Systematic Review 显示文摘 | van Saane N S1uiter J K Verbeek J H | 2003 | Occup Bfed (Lond)2003，53，3： | 1 |
| 15 | Flyer impact experiment to study vulnerability and reactivity of gun propellant formulations 显示文摘 | BOUMA R H B BOLUIJT A G VERBEEK H J | 2009 | Measurement Science and Technology2009，20，9： | 1 |
| 16 | Advance in business process management 显示文摘 | WESKE M van der Aalst W M P VERBEEK H M W | 2004 | Data Knowledge Engineering2004，50，1： | 1 |
| 17 | The secondary FLT3-ITD F691L mutation induces resistance to AC220 in FLT3-ITD+ AML but retains in vitro sensitivity to PKC412 and Sunitinib显示文摘 | Albers C Leischner H Verbeek M | 2013 | Leuke- mia2013，27，6： | 1 |
| 18 | Transcriptome profiling of adult zebrafish at the late stage of chronic tuberculosis due to Mycobacterium marinum infection显示文摘 | Meijer A H Verbeek F J Salas-Vidal E | 2005 | Molecular Immunology2005，42，10： | 1 |
| 19 | Immune complex-loaded dendritic cells are superior to soluble immune complexes as antitumor vaccine显示文摘 | Schuurhuis D H van Monffoort N loan-Facsinay A Jiawan R Camps M Nouta J Melief C J Verbeek J S Os | | 0，，08： | 1 |
| 20 | Reduction rules for YAWL workflows with cancella- tion regions and OR-joins显示文摘 | WYNN M T VERBEEK H M W VAN DER AALST W M P | 2009 | Information and Software Tech nology2009，51，6： | 1 |
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