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	题名	作者	年代	出处	被引量
1	Effect of IFNα-2a on Fas expression and apoptosis rate of peripheral blood cytotoxic T cells in patients with hepatitis B显示文摘Interferon(IFN) with antiviral and im-munomodulatory activities is one of the most important therapeutic agents for the treatment of chronic hepatitis. The apoptotic effect of IFN is influenced by cell type and the types of IFN, which suppresses proliferation and induces apoptosis in some cell types while inhibiting apoptosis in others. The aim of this study was to explore the effect of IFNα-2a on Fas expression and the apoptosis rate of peripheral blood cytotoxic T cells (CTLs) in patients with hepatitis B. METHODS:Peripheral blood mononuclear cells were isolated from 26 patients with hepatitis B including 16 patients with chronic hepatitis B and 10 patients with chronic severe hepatitis B. Fas expression and apoptosis rate of CTLs were analyzed with flow cytometry before and after IFNα-2a treatment. RESULTS:Before IFNα-2a treatment, Fas expression and apoptosis rate of CTLs from patients with chronic hepatitis B were significantly higher than those from patients with chronic severe hepatitis B and healthy controls respectively. No significant difference was observed between Fas expression and apoptosis rate of CTLs from patients with chronic severe hepatitis B and healthy controls. After IFNα-2a treatment,Fas expression and apoptosis rate of CTLs from different groups were compared with those before IFNα-2a treatment, showing no significant difference despite alternation of different degree. CONCLUSIONS:Activation induced cell death (AICD) exists in peripheral blood CTLs from patients with hepatitis B. No effect of IFNα-2a exerts on Fas expression and apoptosis rate of Fas in patients with hepatitis B.	Institute of Infectious Diseases, Zhejiang University School of Medicine, Hangzhou 310003, China (Hou W, Liu KZ, Li MW and Wo JE)	2005	Hepatobiliary & Pancreatic Diseases International2005，4，3：	4
2	Outcome prediction of emergency patients by noninvasive hemodynamic monitoring显示文摘	Shoemaker W C Wo C C Ramicone E	2001	Chest2001，120，：	2
3	Induction of strong hepatitis b virus (hbv) specific t helper cell and cytotoxic t lymphocyte responses by therapeutic vaccination in the trimera mouse model of chromc hbv infection 显示文摘	Bocher WO Dekel B Schwerin W		Eur J Immunol0，31，7：	1
4	Neonatal immu- nization with a single dose of recombinant BCG expressing sub- unit S1 from pertussis toxin induces complete protection against Bordetella pertussis intracerebral challenge 显示文摘	Nascimento IP Dias WO Quintilio W	2008	Microbes Infect2008，10，2：	1
5	Hypopharyngeal pH monitoring artifact in detection of laryngopharyngeal reflux显示文摘	WO J M JABBAR A WINSTEAD W	2002	Dig Dis Sci2002，47，：	1
6	Chem Res Toxieol显示文摘	Behnia K Cornelius G Wang J Shipkova P Johnghar S Washburn W Brigance R Stetsko P Henwood A Wo)ciec- howski J P Marathe P Rodrigues A D Humphreys W G	2011	24(6) :9052011，24，6：	1
7	Problem based learning: future challenges for educational p raetiee and research 显示文摘	Do Imans DH De Grave W Wo llhagen IH	2005	M ed Edue2005，39，5：	1
8	Retracted: Microencapsulation of Intu- mescent Flame-Retardant Agent and Application to Epoxy Resins 显示文摘	Gao M Wo Y Wu W	2011	Journal of Applied Polymer Science2011，119，4：	1
9	Non-fragile controller design for discrete descriptor systems 显示文摘	Wo S L Zou Y Chen Q W	2009	Journal of the Franklin Institute2009，346，9：	1
10	Microencapsulation of intu- mescent flame-retardant agent and application to epoxy resins 显示文摘	GAO M WO Y Q WU W H	2011	J Appl Polym Sci2011，119，4：	1
11	Use of zeta potential meas- urements in catalyst preparation显示文摘	Soled S Wachter W Wo H	2010	Stud Surf Sci Catal2010，175，10：	1
12	Rapid detection of Marek' s disease virus in feather follicles by loop -mediated amplification 显示文摘	Wo Sniakowski G Samorek-Salamonowicz E Kozdruh W	2011	Avian Diseases2011，55，3：	1
13	Noninvasive estimations of cardiac output and circulatory dynamics in critically ill patients显示文摘	Wo C C J Shoemaker W C Bishop M H	1995	Curr Opin Crit Care1995，1，：	1
14	显示文摘	Bocher WO Dekel B Schwerin W	2001	Eur J Immunol2001，31，7：	1
15	Hypopharyngeal pH monitoring artifact in detection of laryngopharyngeal reflux 显示文摘	Wo JM Jabbar A Winstead W	2002	Dig Dis Sci2002，47，11：	1
16	Multicenter trial of a new thoracic electrical bioimpedance device for cardiac output estimation显示文摘	Shoemaker W C Wo C C Bishop M H	1994	Crit Care Med1994，12，：	1
17	Outcome prediction of emergency patients by noninvasive hemodynamic monitoring显示文摘	Shoemaker W C Wo C C Ramicone E	2001	Chest2001，120，2：	1
18	Three-dimensional structure of the tetragonal surface layer of sporosarcina ureae显示文摘	Engelhardt H Saxton WO Baumeister W		0，，1：	1
19	Noninvasive hemodynamic monitoring of acutely ill patients admitted to the emergency department显示文摘	Shoemaker W C Wo C C Bishop M H	1996	Acad Emerg Med1996，3，：	1
20	Noninvasive estimations of cardiac output and circulatory dynamics in critically ill patients显示文摘	Wo C C J Shoemaker W C Bishop M H	1995	Curr Opin Crit Care1995，1，：	1

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