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| 1 | Abnormal activation of the synuclein-gamma gene in hepatocellular carcinomas by epigenetic alteration.显示文摘 | Zhao W Liu H Liu W Wu Y Chen W Jiang B Zhou Y Xue R Luo C Wang L Jiang JD Liu J | 2006 | 中国生物学文摘2006，20，4： | 31 |
| 2 | Corrosion Behavior of 110S Tube Steel in Environments of High H_2S and CO_2 Content显示文摘The corrosion behavior of the 110S tube steel in the environments of high H2S and CO2 content was investigated by using a high-temperature and high-pressure autoclave, and the corrosion products were characterized by scanning electron microscopy and X-ray diffraction technique. The results showed that all of the corrosion products under the test conditions mainly consisted of different types of iron sulfides such as pyrrhotite of Fe0.95S, mackinawite of FeS0.9, Fe0.985S and FeS, and the absence of iron carbonate in the corrosion scales indicated that the corrosion process was controlled by H2S corrosion. The corrosion rate of the 110S steel decreased firstly and then increased with the rising of temperature. The minimum corrosion rate occurred at 110 ℃. When the H2S partial pressure PH2S below 9 MPa, the corrosion rate declined with the increase of PH2S. While over 9 MPa, a higher PH2S resulted in a faster corrosion process. With the increasing of the CO2 partial pressure, the corrosion rate had an increasing trend. The morphologies of the corrosion scales had a good accordance with the corrosion rates. | LI W en-fei ZHOU Yan-jun XUE Yan | 2012 | Journal of Iron and Steel Research(International)2012，19，12： | 23 |
| 3 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 4 | Genome-wide prediction in a hybrid maize population adapted to Northwest China显示文摘Genome-wide prediction is a promising approach to boost selection gain in hybrid breeding.Our main objective was to evaluate the potential and limits of genome-wide prediction to identify superior hybrid combinations adapted to Northwest China.A total of 490 hybrids derived from crosses among 119 inbred lines from the Shaan A and Shaan B heterotic pattern were used for genome-wide prediction of ten agronomic traits.We tested eight different statistical prediction models considering additive(A)effects and in addition evaluated the impact of dominance(D)and epistasis(E)on the prediction ability.Employing five-fold cross validation,we show that the average prediction ability ranged from 0.386 to 0.794 across traits and models.Six parametric methods,i.e.ridge regression,LASSO,Elastic Net,Bayes B,Bayes C and reproducing kernel Hilbert space(RKHS)approach,displayed a very similar prediction ability for each trait and two non-parametric methods(random forest and support vector machine)had a higher prediction performance for the trait rind penetrometer resistance of the third internode above ground(RPR_TIAG).The models of A+D RKHS and A+D+E RKHS were slightly better for predicting traits with a relatively high non-additive variance.Integrating trait-specific markers into the A+D RKHS model improved the prediction ability of grain yield by 3%,from 0.528 to 0.558.Of all 6328 potential hybrids,selection of the top 44 hybrids would lead to a 6%increase in grain yield compared with Zhengdan 958,a commercially successful hybrid variety.In conclusion,our results substantiate the value of genome-wide prediction for hybrid breeding and suggest dozens of promising single crosses for developing high-yielding hybrids for Northwest China. | Guoliang Li Yuan Dong Yusheng Zhao Xiaokang Tian Tobias Würschum Jiquan Xue Shaojiang Chen Jochen C.Reif Shutu Xu Wenxin Liu | 2020 | The Crop Journal2020，8，5： | 4 |
| 5 | Next generation patient-derived prostate cancer xenograft models显示文摘对为前列腺癌症的更有效的治疗学的途径有批评需要。然而,在这个区域的研究被缺乏严重妨碍了临床上相关,在疾病的 vivo 模型试验性。这评论特别地基于 patients’ 的 subrenal 囊 grafting 集中于前列腺癌症异种皮移植模型的发展;进 nonobese 糖尿病 / 严重的肿瘤组织联合了 immunodeficient (NOD/SCID ) 老鼠。这种技术允许可移植的、导出病人的癌症织物异种皮移植线的成功的开发从不仅好攻击变形,而且从局部性的前列腺癌症纸巾。异种皮移植被发现了保留原来的恶意的关键生物性质,包括组织病理学说、分子的特征,肿瘤异质,对雄激素脱离的反应和变形能力。因此,他们是高度临床上相关并且在细胞、分子的层次,为个性化的癌症治疗屏蔽的药和现出症状之前的潜的药为前列腺癌症前进的研究提供珍贵工具测试的功效;特别当模型的一块面板习惯于盖子时许多疾病。这些异种皮移植模型能因此被看作前列腺癌症的下一代的模型。 | Dong Lin Hui Xue Yuwei Wang Rebecca Wu Akira Watahiki Xin Dong Hongwei Cheng Alexander W Wyatt Colin C Collins Peter W Gout Yuzhuo Wang | 2014 | Asian Journal of Andrology2014，16，3： | 4 |
| 6 | Low-temperature sintering of alumina with liquid-forming additives显示文摘 | XUE L A CHEN I W | 1991 | J Am Ceram Soc1991，74，8： | 2 |
| 7 | Immnopotentiation of bovine respiratory disease virus vaccines by interleukin-l and interleukin-2显示文摘 | Reddy D N Reddy P G Xue W | 1993 | Vet Immunol Immopathol1993，37，： | 2 |
| 8 | Influence of additives on the γ-toα transformation of alumina 显示文摘 | XUE L A CHEN L W | 1992 | J Mater Sci Lett1992，11，： | 2 |
| 9 | Generation and analysis of genetically defined liver carcinomas derived from bipotential liver progenitors 显示文摘 | ZENDER L XUE W CORDON-CARI30 C | 2005 | Cold Spring Harb Symp Quant Biol2005，70，： | 1 |
| 10 | Tribological behavior of microarc oxidation coatings on aluminum alloy显示文摘 | Xue W Du J Wu X | 2006 | ISIJ Int2006，46，： | 1 |
| 11 | Effect of micro-arc discharge surface treat-ment on the tensile properties of Al CuMg alloy显示文摘 | XUE W WANG C LI Y | 2002 | Mater Lett2002，56，： | 1 |
| 12 | Fetal protection against bovine viral diarrhea virus types 1 and 2 after the use of a modified-live virus vaccine显示文摘 | XUE W MATTICK D SMITH L | 2009 | Can J Vet Res2009，73，4： | 1 |
| 13 | A comparative study of impulse-resistant metal sandwich plates 显示文摘 | Xue Z Y Hutchinson J W | 2004 | International Journal of Impact Engineering2004，，30： | 1 |
| 14 | Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach显示文摘 | Zender L Spector MS Xue W | 2006 | Cell2006，125，4： | 1 |
| 15 | Enhanced 1,3-propanediol production by supply of organic acids and repeated fed-batch culture显示文摘 | Xue X D Li W Li Z M | 2010 | J Ind Microbiol Biotechnol2010，37，7： | 1 |
| 16 | A comparative study of impulse-resistant metal sandwich plates显示文摘 | Xue Zhenyu Hutchinson John W | 2004 | International Journal of Impact Engineering2004，，30： | 1 |
| 17 | Combination of thrombin and matrix metalloproteinase-9 exacerbates neurotoxicity in cell culture and intracerebral hemorrhage in mice 显示文摘 | Xue M Hollenberg M D Yong V W | 2006 | J Neurosci2006，26，10： | 1 |
| 18 | Development of a mode of application of bioorganic fertilizer for improving the biocontrol efficacy to Fusarium wilt 显示文摘 | Ling N Xue C Huang Q W | 2010 | Biocontro12010，55，： | 1 |
| 19 | Genome-wide analysis of the complex transcriptional networks of rice Developing Seeds 显示文摘 | Xue L J Zhang J J Xue H W | 2012 | PLoS ONE2012，7，31： | 1 |
| 20 | Abnormal Fas/FasL and Caspase-3-mediated apoptotic signaling pathways of T lymphocyte subset in patients with systemic lupus erythematosus显示文摘 | Xue C Lan-Lan W Bei C | 2006 | Cell Immunol2006，239，2： | 1 |
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