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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | Imaging of renal lesions: evaluation of fast MRI and helical CT显示文摘 | Walter C Kruessell M Gindele A | 2003 | Br J Radiol2003，76，910： | 2 |
| 3 | Prolactin production from proliferative phase leiomyoma显示文摘 | DALY D C WALTERS C A PRIOR J C | 1984 | Am J Obstet Gynecol1984，148，8： | 2 |
| 4 | Aberrant p53 protein expression is associated with an increased risk of neoplastic progression in patients with Barrett’s oesophagus显示文摘 | Florine Kastelein Katharina Biermann Ewout W Steyerberg Joanne Verheij Marit Kalisvaart Leendert H J Looijenga Hans A Stoop Laurens Walter Ernst J Kuipers Manon C W Spaander Marco J Bruno | 2013 | Gut2013，，12： | 2 |
| 5 | Mercury speciation in fluorescent lamps by thermal release analysis显示文摘 | CLAUDIO R CLAUDIO C WALTER A D J | 2003 | Waste Management2003，23，10： | 1 |
| 6 | The MAFT architecture for distributed fault - tolerance 显示文摘 | Kieckhafer R M Walter C J Finn A M | 1988 | IEEE Trans Computers1988，37，4： | 1 |
| 7 | Synthesis of 4,4-divinyl-2,2-bipyridine显示文摘 | Leopoldo D C Walter J Dressick A | 1990 | Journal of Heterocycl Chemistry1990，27，2： | 1 |
| 8 | Distribution of some volatile nitrosamines in cooked bacon显示文摘 | GOUGH T A GOOGHEAD K WALTERS C L | 1976 | Journal of the Science of Food and Agriculture1976，27，2： | 1 |
| 9 | Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome显示文摘 | Walters A S Lebrocq C Dhar A | 2003 | Sleep Med2003，4，： | 1 |
| 10 | Identification of mi- crobial and thermogenic gas components from Upper Devonian black shale cores,Illinois and Michigan basins显示文摘 | Martini A M Walter L M Mclntosh J C | 2008 | AAFG Bul- letin2008，92，3： | 1 |
| 11 | On fast decoupled continuation power flows 显示文摘 | Mohn Fritz Walter de Souza A C Z | 2002 | Electric Power Systems Research2002，63，： | 1 |
| 12 | Extensive microbial modificationof formation water geochemistry:Case study from a Midcontinentsedimentary basin,United States显示文摘 | McIntosh J C Walter L M Martini A M | 2004 | Geological Society of America Bulletin2004，116，56： | 1 |
| 13 | Higher rates of autism and attention deficit/hyperactivity disorder in American children:Are food quality issues impacting epigenetic inheritance?显示文摘In the United States,schools offer special education services to children who are diagnosed with a learning or neurodevelopmental disorder and have difficulty meeting their learning goals.Pediatricians may play a key role in helping children access special education services.The number of children ages 6-21 in the United States receiving special education services increased 10.4%from 2006 to 2021.Children receiving special education services under the autism category increased 242%during the same period.The demand for special education services for children under the developmental delay and other health impaired categories increased by 184%and 83%respectively.Although student enrollment in American schools has remained stable since 2006,the percentage distribution of children receiving special education services nearly tripled for the autism category and quadrupled for the developmental delay category by 2021.Allowable heavy metal residues remain persistent in the American food supply due to food ingredient manufacturing processes.Numerous clinical trial data indicate heavy metal exposures and poor diet are the primary epigenetic factors responsible for the autism and attention deficit hyperactivity disorder epidemics.Dietary heavy metal exposures,especially inorganic mercury and lead may impact gene behavior across generations.In 2021,the United States Congress found heavy metal residues problematic in the American food supply but took no legislative action.Mandatory health warning labels on select foods may be the only way to reduce dietary heavy metal exposures and improve child learning across generations. | Renee J Dufault Raquel A Crider Richard C Deth Roseanne Schnoll Steven G Gilbert Walter J Lukiw Amanda L Hitt | 2023 | World Journal of Clinical Pediatrics2023，12，2： | 1 |
| 14 | In-plane-aligned membranes of carbon nanotubes显示文摘 | Walters D A Casavant M J Qin X C | 2001 | Chemical Physics Letters2001，338，1： | 1 |
| 15 | Microbial pro-duction and modification of gases in sedimentary basins:A geochemical case study from a Devonian shale gas play,Michigan basin显示文摘 | Martini A M Walter L M Ku T C W | 2003 | AAPG Bulletin2003，87，8： | 1 |
| 16 | Amino acid changes within the Bunyamwera virus nucleocapsid protein differentially affect the mRNA transcription and RNA replication activities of assembled ribonucleoprotein templates显示文摘 | Walter C T Bento D F C Alonso A G Barr J N | 2011 | J Gen Virol2011，92，1： | 1 |
| 17 | Segregation and linkage of several genes in cucumber显示文摘 | Walters S A Shetty N V Wehner T C | 2001 | Journal of the American Society for Horticultural Science2001，126，4： | 1 |
| 18 | Incidence of bisphospho-nate-associated osteonecrosis of the jaws in breast cancer patients显示文摘 | Walter C Al-Nawas B du Bois A | 2009 | Cancer2009，115，8： | 1 |
| 19 | Spatial prediction of topsoil salinity in the Chelif Valley, Algeria, using local ordinary kriging with local variograms Versus whole-area variorum显示文摘 | Walter C MeBratney A B Douaoui A | 2001 | Australian Journal of Soil Research2001，39，2： | 1 |
| 20 | Root knot nematode resistance in cucumber and horned cucumber显示文摘 | Walters S A Wehner T C Barker K R | 1993 | Hort Science1993，28，2： | 1 |
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