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| 1 | S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3显示文摘建筑群由 S100 钙绑定蛋白质家庭,的二个成员形成了 S100A8/A9,在不同起源的各种各样的房间施加导致 apoptosis 活动。这里,我们内在的分子的机制包含的现在的证据两个都规划了房间死亡我(PCD 我, apoptosis ) 并且象死亡一样的 PCD II (autophagy ) 。有 S100A8/A9 的房间的处理引起了 Beclin-1 表示以及 Atg12-Atg5 形成的增加。S100A8/A9-induced 房间死亡被特定的 PI3-kinase 班 III 禁止者部分禁止, 3-methyladenine (3 麻省) ,并且由液泡 H+-ATPase 禁止者, bafilomycin-A1 (Baf-A1 ) 。S100A8/A9 挑起了 BNIP3 的 translocation, BH3 仅仅 pro-apoptotic Bcl2 家庭成员,到线粒体。与这发现一致,螖 T M-BNIP3 overexpression 部分禁止了 S100A8/A9-induced 细胞死亡,减少的反应的氧种(ROS ) 产生,并且部分在 S100A8/A9-treated 细胞在 mitochondrial transmembrane 潜力免于减少。另外,任何一个螖 T M-BNIP3 overexpression 或 N-acetyl-L-cysteine 合作处理减少了在与 S100A8/A9 对待的房间的 lysosomal 激活。我们的数据显示 S100A8/A9-promoted 房间死亡通过线粒体的串音发生,经由 ROS 和这个过程的 lysosomes 包含 BNIP3。 | Saeid Ghavami Mehdi Eshragi Sudharsana R Ande Walter J Chazin Thomas Klonisch Andrew J Halayko Karol D Mcneill Mohammad Hashemi Claus Kerkhoff Marek Los | 2010 | Cell Research2010，20，3： | 13 |
| 2 | Mercury speciation in fluorescent lamps by thermal release analysis显示文摘 | CLAUDIO R CLAUDIO C WALTER A D J | 2003 | Waste Management2003，23，10： | 1 |
| 3 | Use of random amplified polymorphic DNA ( RAPD ) for identification of largemouth bass subspecies and their intergrades显示文摘 | Williams D J Kazianis S Walter R B | 1998 | Transactions of the American Fisheries Society1998，127，： | 1 |
| 4 | Inhibition of nitrification by acetylene显示文摘 | Walter H M Keeney D R Fillery I R | 1979 | Soil Science Society of America Journal1979，43，1： | 1 |
| 5 | Secretoneurinan angiogenic neuropeptide,induces postnatal vasculogenesis显示文摘 | Kirchmair R Egger M Walter D H | 2004 | Circulation2004，110，9： | 1 |
| 6 | Induction of systemic resistance to rust in Vicia faba by pho-sphates and EDTA:effects of calcium显示文摘 | WAlTERS D R MURRAY D C | 1992 | Plant Pathol1992，41，： | 1 |
| 7 | Influence of CD33 expression levels and ITIM-dependent internalization on gemtuzumab ozogamicin-induced cytotoxicity显示文摘 | Walter R B Raden B W Kamikura D M | 2005 | Blood2005，105，3： | 1 |
| 8 | Genistin(an isoflavone glueoside)and its aglucone,genis- tein,from soybeans显示文摘 | Walter R D | 1941 | Journal of the American chemical Society1941，63，： | 1 |
| 9 | Manufacturing and performance of nanometric Al-MoO3 energetic materials显示文摘 | Walter K C Pesiri D R Dennis E W | | 0，，4： | 1 |
| 10 | Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients显示文摘 | Cook D J Walter S D Cook R J | | 0，，06： | 1 |
| 11 | Incidence of and risk factors for ventilator associated pneumonia in criticuly ill patients 显示文摘 | Cook D J Walter S D Cook R J | 1998 | Ann Intem Med1998，129，： | 1 |
| 12 | The Effect Negative Word of Mouth Behavior and Repatronage Intention 显示文摘 | Blodgett G J Granbois D H Walters of Perceived Justice on Complaints' R G | 1993 | Retailing1993，69，12： | 1 |
| 13 | Interferons, interferon-like eytokines, and their receptors显示文摘 | Pestka S Krause C D Walter M R | 2004 | Immunol Rev2004，202，： | 1 |
| 14 | QIIME allows analysis of high-throughput community sequencing data 显示文摘 | Caporaso JG Kuczynski J Stombaugh J Bittinger K Bushman FD Costello EK Fierer N Pena AG Goodrich JK Gordon JI Huttley GA Kelley ST Knights D Koenig JE Ley RE Lozupone CA Mcdonald D Muegge BD Pirrung M Reeder J Sevinsky JR Tumbaugh PJ Walters WA Widmann J Yatsunenko T Zaneveld J Knight R | 2010 | Nat Methods2010，7，5： | 1 |
| 15 | Evidence for divergence of restriction fragment length polymorphism patterns following invivo replication of porcine reproductive and respiratory syndrome virus显示文摘 | Wesley R D Mengeling W L walter K M | 1999 | Am J Vet Res1999，60，： | 1 |
| 16 | Altering the strength of lectin binding interactions and controlling the amount of lectin clustering usingmannose/hydmxyl-functionalized dendrimers显示文摘 | WOLLER E K WALTER E D MORGAN J R | 2003 | Journal of the American Chemical Society2003，125，29： | 1 |
| 17 | Meta-analysis of screening data:a survey of the literature显示文摘 | Walter S D Jadad A R | 1999 | Stat Med1999，18，24： | 1 |
| 18 | Benefits of pulmonary artery catheter and transesophageal echocardiographic monitoring in laparoseop iceholecystectomy patients with cardiac disease显示文摘 | Portera C A Compton R E Walters D N | 1995 | Am J surg1995，169，2： | 1 |
| 19 | Mitogen and substrate differentially affect the lineage restriction of adult rat subventricular zone neural precursor cell populations 显示文摘 | Whittemore S R Morassutti D J Walters W M | 1999 | Exp Cell Res1999，252，： | 1 |
| 20 | Genetic improvement of seedling emergence of soybean lines with low phytate显示文摘 | Jordan D S Walter R F | | 0，，04： | 1 |
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