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| 1 | A possible relationship between serum sex hormones and benign prostatic hyperplasia/Iower urinary tract symptoms in men who underwent transurethral prostate resection显示文摘 | Yu Wu Hong Pan Wei-Ming Wang Ding Xu Liang Zhang Zheng-Qin Gu Qiang Bai un Qi e-Feng Huang | 2017 | Asian Journal of Andrology2017，19，2： | 17 |
| 2 | Inactivation of TFEB and NF-kB by marchantin M alleviates the chemotherapy-driven pro-tumorigenic senescent secretion显示文摘It is critical to regulate the senescence-associated secretory phenotype(SASP) due to its effect on promoting malignant phenotypes and limiting the efficiency of cancer therapy. In this study, we demonstrated that marchantin M(Mar-M, a naturally occurring bisbibenzyl) suppressed proinflammatory SASP components which were elevated in chemotherapy-resistant cells. Mar-M treatment attenuated the pro-tumorigenic effects of SASP and enhanced survival in drug-resistant mouse models.No toxicity was detected on normal fibroblast cells or in animals following this treatment. Inactivation of transcription factor EB(TFEB) and nuclear factor-k B(NF-k B) by Mar-M significantly accounted for its suppression on the components of SASP. Furthermore, inhibition of SASP by Mar-M contributed to a synergistic effect during co-treatment with doxorubicin to lower toxicity and enhance antitumor efficacy. Thus, chemotherapy-driven pro-inflammatory activity, seen to contribute to drug-resistance, is an important target for Mar-M. By decreasing SASP, Mar-M may be a potential approach to overcome tumor malignancy. | Huanmin Niu Lilin Qian Bin Sun Wenjian Liu Fang Wang Qian Wang Xiaotian Ji Yanhai Luo Effat Un Nesa Hongxiang Lou Huiqing Yuan | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 4 |
| 3 | Co-infection of SENV-D among chronic hepatitis C patients treated with combination therapy with high-dose interferon-alfa and ribavirin显示文摘AIM: The clinical significance of co-infection of SENV-D among patients with chronic hepatitis C (CHC) and response of both viruses to combination therapy with high-dose interferon-alfa (IFN) plus ribavirin remain uncertain and are being investigated.METHODS: Total 164 (97 males and 67 females, the mean age 48.1±11.4 years, range: 20-73 years, 128histologically proved) naive CHC patients were enrolled in this study. SENV-D DNA was tested by PCR method.Detection of serum HCV RNA was performed using a standardized automated qualitative RT-PCR assay (COBAS AMPLICOR HCV Test, version 2.0). HCV genotypes 1a,1b, 2a, 2b, and 3a were determined by using genotypespecific primers. Pretreatment HCV RNA levels were determined by using the branched DNA assay (Quantiplex HCV RNA 3.0). There are 156 patients receiving combination therapy with IFN 6 MU plus ribavirin for 24 wk and the response to therapy is determined.RESULTS: Sixty-one (37.2%) patients were positive for SENV-D DNA and had higher mean age than those who were negative (50.7±10.6 years vs46.6±11.6 years,P = 0.026). The rate of sustained viral response (SVR)for HCV and SENV-D were 67.3% (105/156) and 56.3%(27/48), respectively. By univariate analysis, the higher rate of SVR was significantly related to HCV genotype non-1b (P<0.001), younger ages (P = 0.014), lower pretreatment levels of HCV RNA (P = 0.019) and higher histological activity index (HAI) score for intralobular regeneration and focal necrosis (P = 0.037). By multivariate analyses, HCV genotype non-1b, younger age and lower pretreatment HCV RNA levels were significantly associated with HCV SVR (odds ratio (OR)/95% confidence interval (CI): 12.098/0.02-0.19, 0.936/0.890-0.998, and 3.131/1.080-9.077, respectively). The SVR of SENV-D was higher among patients clearing SENV-D than those who had viremia at the end of therapy (P = 0.04).CONCLUSION: Coexistent SENV-D infection, apparently associated with higher ages, is found in more than onethird Taiwan Residents CHC patients. Both HCV and SENV-D are highly susceptible to combination therapy with high-dose IFN and ribavirin and SENV-D co-infection does not affect the HCV response. HCV genotype, pretreatment HCV RNA levels and age are predictive factors for HCV SVR. | Chia-Yen Dai Wan-Long Chuang Wen-Yu Chang Shinn-Chemg Chen Li-Po Lee Ming-Yen Hsieh Nei-Jen Hou Zu-Yau Un Ming-Yuh Hsieh Liang-Yen Wang Ming-Lung Yu | 2005 | World Journal of Gastroenterology2005，11，27： | 4 |
| 4 | Relative frequency and survival of primary cutaneous lymphomas: a retrospective analysis of 98 patients显示文摘 | Liu J Liu YH Jin HZ Ma DL Qu T Wang T S un QN Yu X | 2014 | Chinese Medical Journal2014，，4： | 2 |
| 5 | Synthesis and pho toluminescence of CeOe : Eu3+ phosphor powders显示文摘 | Xiaohua Liu Shaoj un Chen Xiaodong Wang | 2007 | Journal of Luminescence2007，127，2： | 1 |
| 6 | Simulated delayed coking characteristics of petroleum residues and fractions by thermogravimetry显示文摘 | Guo Aij un Zhang Xuejun Wang Zongxian | 2008 | Fuel Processing Technology2008，89，64： | 1 |
| 7 | Constructing Error-correcting Pooling Designs with Sympelectic Space 显示文摘 | GUO J un WANG Yuexuan GAO Suogang | 2010 | J Comb Optim2010，20，： | 1 |
| 8 | Degradation characteristics of secondary effluent of domestic wastewater by combined process of ozonation and biofiltration显示文摘 | WANG Shutao MA J un LIU Baicang | 2008 | Hazardous Materials2008，150，1： | 1 |
| 9 | Deploying Wireless Sensor Networks Under Limited Mobility Constraints显示文摘 | Chellappan S Wang Wen-j un Bai Xiao-le | 2007 | Mobile Computing2007，6，10： | 1 |
| 10 | Single relay selection with feedback and power allocation in multisource multidestination cooperative networks显示文摘 | WANG H YANG S Z UN J Z | 2010 | IEEE Signal Processing Letters2010，17，12： | 1 |
| 11 | Perifosinedownregulates MDR1 gene expression and reverses multidrugresistant phenotype by inhibiting PI3K/Akt/NF- kappaB signaling pathway in ahuman breast cancer cell line显示文摘 | UN X ZHANG X WANG Q etal | 2012 | Neoplasma2012，59，3： | 1 |
| 12 | A decentralized fuzzy inference method for solving two - dimensional steady inverse heat conduction problem of estimating boundary condition 显示文摘 | Guan un Wang Lina Zhu Hong Chen | 2011 | International Journal of Heat and Mass Transfer2011，54，： | 1 |
| 13 | Preparation and Thermal Properties of Form-stable Paraffin Phase Change Material Encapsulation显示文摘 | LIU Xing LIU Hong-yan WANG Shu-j un | 2006 | Solar Energy2006，，2： | 1 |
| 14 | Role of specific innate immune responses in herpes simplex virus infection of the central nervous system显示文摘 | Wang JP Bowen UN Zhou S | 2012 | J Viro12012，86，4： | 1 |
| 15 | Adaptive hypergraph lear- ning and its application in image classification 显示文摘 | Yu J un Tao Da-cheng Wang Meng | 2012 | IEEE Trans- actions on Image Processing2012，21，7： | 1 |
| 16 | Curing Kinetics and Properties of Epoxy Resin-fluorenyl Diamine Systems显示文摘 | LIU Wen bin QIU Qi-hao WANG J un | 2008 | Polymer2008，49，20： | 1 |
| 17 | Ffferls of BMP -2 andVKGF165 on the osteogenic dilTereiUiation of rat honemarrow - derived mesenchymal stem cells 显示文摘 | Lin Z Wang J S Un L el al | 2014 | Kxp TherMed2014，7，3： | 1 |
| 18 | Expression of IL-23 and IL-17 and effect of IL-23 on IL-17 production in ankylosing spondy-litis显示文摘 | Wang X Un Z Wei Q | 2009 | Rheumatol Int2009，29，： | 1 |
| 19 | Preparation and properties of nano-silica/calcium alginate blend fibers 显示文摘 | Wang Fen~un Ji Quan Zhang Jianjun | 2011 | Adv Mater Res2011，，： | 1 |
| 20 | Microstructure and corrosion properties of as sub-rapid solidification Mg-Zn- Y-Nd alloy in dynamic simulated body fluid for vascular stent application显示文摘 | Wang j un Wang Liguo Guan Shaokang | 2010 | Journal of Materials Science: Materials in Medicine2010，21，7： | 1 |
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