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181篇 您的检索式:作者名="WATTS M L"
    题名 作者 年代 出处 被引量
1Role of the gut microbiota in inflammatory bowel disease pathogenesis: What have we learnt in the past 10 years?显示文摘Our understanding of the microbial involvement in inflammatory bowel disease(IBD) pathogenesis has increased exponentially over the past decade. The development of newer molecular tools for the global assessment of the gut microbiome and the identification of nucleotide-binding oligomerization domain-containing protein 2 in 2001 and other susceptibility genes for Crohn's disease in particular has led to better understanding of the aetiopathogenesis of IBD. The microbial studies have elaborated the normal composition of the gut microbiome and its perturbations in the setting of IBD. This altered microbiome or 'dysbiosis' is a key player in the protracted course of inflammation in IBD. Numerous genome-wide association studies have identified further genes involved in gastrointestinal innate immunity(including polymorphisms in genes involved in autophagy: ATG16L1 and IGRM), which have helped elucidate the relationship of the local innate immunity with the adjacent luminal bacteria. These developments have also spurred the search for specific pathogens which may have a role in the metamorphosis of the gut microbiome from a symbiotic entity to a putative pathogenic one. Here we review advances in our understanding of microbial involvement in IBD pathogenesis over the past 10 years and offer insight into how this will shape our therapeutic management of the disease in the coming years.Georgina L Hold Megan Smith Charlie Grange Euan Robert Watt Emad M El-Omar Indrani Mukhopadhya 2014World Journal of Gastroenterology2014,20,5:21
2Effects of dynamic exer- cise intensity on the activation of hormone-sensitive lipase in human skeletal muscle 显示文摘Watt M J George JF Lawrence L 2003J Physiol2003,547,1:1
3The Relation between Earnings and Cash Flows显示文摘DECHOW P M KOTHARI S P WATTS R L 1998Journal of Accounting and Economics1998,25,2:1
4Isolation and partial characterisation of immunoglobulin from southern bluefin tuna Thunnus maccoyii Castelnau显示文摘Watts M Munday B L Burke C M 0,,06:1
5Mafic dikes displacing Witwatersrand gold reefs: evidence against metamorphic-hy drothermal ore formation显示文摘Meier D L Heinrich C A Watts M A 2009Geology2009,37,7:1
6Decentralization of the firm:theory and evidence显示文摘CHRISTIE A A JOYE M P WATTS R L 2003Journal of Corporate Finance2003,9,1:1
7Mechanism of action of a peroxisome proliferator-activated receptor (PPAR)-delta agonist on lipoprotein metabolism in dyslipidemic subjects with central obesity 显示文摘Ooi E M Watts G F Sprecher D L 2011J Clin Endocrinol Metab2011,96,10:1
8A study of electrochemically treated PAN based carbon fibers by IGC and XPS显示文摘Lindsay B Abel M L Watts J F 2007Carbon2007,45,12:1
9The effect of simulated cold weather transport on core body temperature and behavior of broilers 显示文摘Strawford M L Watts J M Crowe T G 2011Poultry Science2011,90,11:1
10The influence of crown rust on tiller production and survival of peren- nial ryegrass (Lolium perenne ) plants in simulated swards显示文摘Plummer R M Hall R L Watt T A 1990Grass and Forge Science1990,45,:1
11Crimean-Congo hemorrhagic fever:history,epidemiology,pathogenesis,clinical syndrome and genetic diversity显示文摘Bente D A Forrester N L Watts D M Mcauley A J Whitehouse C A 2013Antiviral Res2013,100,:1
12Heat and moisture production by broilers during simulated cold weather transport 显示文摘Watts J M Graft L J Strawford M L 2011Poultry Science2011,90,9:1
13Job satisfaction, mental health, and job stressors among general dental practitioners in the UK显示文摘COOPER C L WATTS J KELLY M 1987Br Dent J1987,162,2:1
14Chemical calcium indicators显示文摘Paredes R M Etzler J C Watts L T Zheng W Lechleiter J D 2008Methods2008,46,:1
15Human endothelial stem/progenitor cells, angiogeflic factors and vascular repair显示文摘Watt S M Athanassopoulos A Harris A L 2010J R Soc Interface2010,7,6:1
16Hormone-sensitive lipase is reduced in the adipose tissue of patients with type 2 diabetes mellitus: influence of IL-6 infusion 显示文摘WATT M J CAREY A L WOLSK-PETERSEN E 2005Diabetologia2005,48,:1
17Estimation and empirical properties of a firm-year of conservatism 显示文摘Khan M Watts R L 2009Journal of Accounting and Economics2009,48,23:1
18Nitrogen transformationsin coal during pyrolysis显示文摘KELEMEN S R GORBATY M L KWIATEK P J FLETCHER T H WATT M SOLUM M S PUGMIRE R J 1998Energy Fuels1998,12,1:1
19Skin-to-skin contact is anal- gesic in healthy newhorns显示文摘Gray L Watt L Blass E M 2000Pediatrics2000,105,1:1
20Chemistry and potential mutagenicity of humic sub- stances in waters from different watersheds in Britain and Ireland 显示文摘Watt B E Malcolm R L Hayes M H B 1996Water Research1996,30,6:1
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