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| 1 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 2 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 3 | 热应激和低营养摄入对猪肠道完整性和功能的影响显示文摘热应激会损害肠道完整性,并诱发肠渗漏。因此,本试验研究了直接或间接热应激(通过减少采食量)对生长猪肠道通透性的影响。选用体重(43±4)kg的杂交后备母猪(n=48),分别安置在以下控制环境中:热中性(TN)环境(20℃,湿度35%~50%,自由采食)、热应激(HS)环境(35℃,湿度20%~35%,自由采食)、热中性环境配对饲喂(PFTN,以消除不同采食量的交互影响)。第1、3、7天使猪只安乐死,采集的空肠样品被安装到尤式灌流室,测定跨膜电阻抗值(TER)和异硫氰基荧光标记的脂多糖(LPS)渗透性(APP,表示为表观渗透系数)。此外,评估肠道完整性以及应激基因和蛋白标志物。结果表明,不考虑热应激天数,HS组与TN组猪相比,血浆内毒素水平增加45%(P〈0.05),空肠TER降低30%(P〈0.05),LPS渗透率增加2倍(P〈0.01)。此外,与PFTN组相比,HS组第7天的猪LPS渗透性有增加的趋势(P=0.06)。整个试验阶段HS组溶菌酶和碱性磷酸酶活性下降,分别下降46%和59%(P〈0.05);然而,3 d和7 d空肠免疫细胞标记物——髓过氧化物酶活性增加(P〈0.05)。由此可见,热应激和减少采食量都会降低肠道完整性,并增加内毒素渗透性。推测这可能会导致炎症加重,在炎热的夏季可能是导致猪生长性能降低的原因。 | Pearce S C Mani V Weber T E Rhoads R P Patience J F Baumgard L H Gabler N K | 2016 | 中国饲料2016，，3： | 3 |
| 4 | Direct measurement of drainage curves in infiltration of SiC particle preforms显示文摘 | BAHRAINI M MOLINA J M WEBER L | 2008 | Materials Science and Engineering:A2008，495，12： | 1 |
| 5 | Morphine induces mesangial cell proliferation and glomerulopathy via kappa-opioid receptors显示文摘 | WEBER M L FAROOQUI M NGUYEN J | 2008 | Am J PhysioI Renal Physiol2008，294，6： | 1 |
| 6 | Mutation of Short Tandem Repeats显示文摘 | WEBER S J L C WONG | 1993 | Hum Mol Genet1993，2，： | 1 |
| 7 | Survey of plant short tandem DNA repeats显示文摘 | Wang Z Weber J L Zhong G | 1994 | Theor Appl enet1994，88，1： | 1 |
| 8 | In vitro assessment of arsenic bioaccessibility in contaminated (anthropogenic and geogenie) soils 显示文摘 | JUHAZE A L SMITH E WEBER J | 2007 | Chemosphere2007，69，1： | 1 |
| 9 | Toxic response as a quantitative function of body size显示文摘 | Anderson P D Weber L J | 1975 | Toxicology and Applied Pharmacology1975，33，3： | 1 |
| 10 | Experiments on flow at a 90 open-ehanneljunction显示文摘 | Weber L J Schumate E D Mawer N | 2001 | JournalofHydranlicEngineering2001，127，5： | 1 |
| 11 | Carbon and oxygen isotopic composi tion of selected limestones and fossils显示文摘 | Keith M L Weber J N | 1964 | Geochimica et Cos- mochimica Acta1964，28，10： | 1 |
| 12 | Scripta Materialia显示文摘 | Tavangar R Molina J M Weber L | 2007 | 56(5): 3572007，56，5： | 1 |
| 13 | Informativeness of human (dG-dT),n(dA-dC)n polymorphisms显示文摘 | Weber J L | 1990 | Genome1990，27，： | 1 |
| 14 | Framework for constructing elastic reservoir simulation models显示文摘 | Weber W J van Geuns L C | 1990 | Journal of Petroleum Technology1990，42，10： | 1 |
| 15 | Three-dimensional numericalstudy of flows in open-channel junctions显示文摘 | Huang J Weber L J Lai Y G | 2002 | J Hydr En-grg ASCE2002，128，3： | 1 |
| 16 | Horizontal transmission of hepatitis B virus 显示文摘 | Davis L C Weber D J Lemon S M | 1989 | Lancet1989，1，8643： | 1 |
| 17 | Growth in emission transfers via international trade from 1990 to 2008 显示文摘 | Peters G P Minx J C Weber C L | 2011 | Proceedings of the National Academy of Sciences2011，108，21： | 1 |
| 18 | Three-dimensional numerical study of flows in open-channel junctions显示文摘 | Huang J C Weber L J Lai Y G | 2002 | Journal of Hydraulic Engineering2002，128，3： | 1 |
| 19 | A review of available prosthetics for ventral hernia repair显示文摘 | SHANKARAN V WEBER D J REED R L | 2011 | Annals of Surgery2011，253，1： | 1 |
| 20 | Altered expression of cellular genes in neutrophils of pefiparturient dairy cows显示文摘 | aMadsen S A Weber P S Burton J L | 2002 | Veterinary immunology and immunopathology2002，86，34： | 1 |
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