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| 1 | Alcoholic pancreatitis:New insights into the pathogenesisand treatment显示文摘Acute pancreatitis is a necro-inflammatory disease of the exocrine pancreas that is characterized by inappropriate activation of zymogens, infiltration of the pancreas by inflammatory cells, and destruction of the pancreatic exocrine cells. Acute pancreatitis can progress to a severe life-threatening disease. Currently there is no pharmacotherapy to prevent or treat acute pancreatitis. One of the more common factors associated with acute pancreatitis is alcohol abuse. Although commonly associated with pancreatitis alcohol alone is unable to cause pancreatitis. Instead, it appears that alcohol and its metabolic by-products predispose the pancreas to damage from agents that normally do not cause pancreatitis, or to more severe disease from agents that normally cause mild pancreatic damage. Over the last 10 to 20 years, a tremendous amount of work has defined a number of alcohol-mediated biochemical changes in pancreatic cells. Among these changes are: Sustained levels of intracellular calcium, activation of the mitochondrial permeability transition pore, endoplasmic reticulum stress, impairment in autophagy, alteration in the activity of transcriptional activators, and colocalization of lysosomal and pancreatic digestive enzymes. Elucidation of these changes has led to a deeper understanding of the mechanisms by which ethanol predisposes acinar cells to damage. This greater understanding has revealed a number of promising targets for therapeutic intervention. It is hoped that further investigation of these targets will lead to the development of pharmacotherapy that is effective in treating and preventing the progression of acute pancreatitis. | Dahn L Clemens Katrina J Schneider Christopher K Arkfeld Jaclyn R Grode Mark A Wells Shailender Singh | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 10 |
| 2 | Factors associated with pressure ulcers in adults in acute care hospitals显示文摘 | FISH ER A R WELL S G HARRISON M B | 2004 | Holist Nurs Pract2004，18，5： | 1 |
| 3 | Transport of genistein-7-glucoside by human intestinal Caco-2 cells: poteintial role for MRP2 显示文摘 | Wells U K French K L Walgren R A | 1999 | Res Comm Mole Pathol Pharm1999，103，1： | 1 |
| 4 | Optimization of a bath for electroless plating and its use for the produc- tion of nickel - phosphorus - silicon carbide coatings 显示文摘 | Kalantary M R Holbrook K A Wells P B | 1993 | Transaction of Institute of Metal Finishing1993，71，2： | 1 |
| 5 | Preliminary observations on the pathogenesis of experimental bovine spongiform encephalopathy (BSE):an update显示文摘 | Wells G A H Hawkins S A C Green R B | 1998 | 142:103-1061998，142，： | 1 |
| 6 | Dry matter allocation and fruiting pat- terns of cotton grown in two divergent plant populations 显示文摘 | JONES M A WELLS R | 1998 | Crop Sci1998，37，： | 1 |
| 7 | First generation computerized Fluoroscopic navigation in percutaneous pelvic surgery显示文摘 | Mosheiff R Khoury A Well Y | 2004 | J Orthop Trauma2004，18，2： | 1 |
| 8 | Fourier trans- form detection in a cylindrical quadrupole ion trap 显示文摘 | Badman E R Wells J M Bui H A | 1998 | A- nal Chem1998，70，17： | 1 |
| 9 | Tallow aleohol sultates, properties in relation to chemical modification 显示文摘 | well J K Stirton A J Bistlire R G | 1959 | JAOCS1959，36，6： | 1 |
| 10 | Motility is rate-limitingfor in- vasion of bladder carcinoma cell lines 显示文摘 | Kassis J Radinsky R Wells A | 2002 | Int J Biochem Cell Biol2002，34，7： | 1 |
| 11 | Factors associated with pressure ulcers in adults in acute care hospitals显示文摘 | FISHER A R WELLS G HARRISON M B | 2004 | Holist Nurs Pract2004，18，5： | 1 |
| 12 | Genetic variability for seed size of two-and three parent soybean population显示文摘 | Johnson S L W R Fehr G A Wells | 2001 | Crop Science2001，41，： | 1 |
| 13 | Water Balance and Unsaturated Flow 显示文摘 | WELLINGS S R Recharge of the Chalk Aquifer at a Site in Hampshire England 1 | 1984 | Journal of Hydrology1984，69，1： | 1 |
| 14 | ZD6474 suppresses oncogenic RET isoforms in a Drosophila model for type 2 multiple endocrine neoplasia syndromes and papillary thyroid carcinoma显示文摘 | Vidal M Wells S Ryan A Cagan R | | 0，，09： | 1 |
| 15 | Placental apoptosis in preeclampsia显示文摘 | Allaire A D Ballerger K A Wells S R | 2000 | Obstet Gynecol2000，96，： | 1 |
| 16 | IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpain显示文摘 | Bodnar R J Yates C C Wells A | 2006 | Circ Res2006，98，5： | 1 |
| 17 | Minimum important difference between patients with rheumatoid arthritis: the patient's perspective 显示文摘 | Wells G A Tugwell P Kraag G R | 1993 | J Rheumatol1993，20，3： | 1 |
| 18 | Antiviral activity of CHOSS cell-derived human omega interferon and other human interferons against HCV RNA replicons and related viruses显示文摘 | Buckwold V E Wei J Huang Z Huang C Nalca A Wells J Russell J Collins B Ptak R Lang W Scribner C Blanchett D Alessi T Langecker P | 2007 | AntiviralResearch2007，73，2： | 1 |
| 19 | A stakeholder Approach to Strategic Performance Measurement 显示文摘 | ATKINSON A WATERHOUSE J WELLS R | 1997 | loan Management Review1997，38，3： | 1 |
| 20 | Glyphosate and Water-stress Effects on Fruiting and Carbohydrates in Glyphosate-resistant Cotton显示文摘 | PLINE W A WELLS R LITTLE G | 2003 | Crop Sci2003，43，： | 1 |
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