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| 1 | Ⅰ期癌症患者切除淋巴结内隐匿性微小转移癌灶的检查及其临床病理意义显示文摘目的 检查癌症患者切除淋巴结内有无微小癌转移 ,具有临床、病理重要性。方法 350例 期癌症患者包括非小细胞肺癌 94例 ,乳腺癌 112例 ,食管癌 115例及外阴癌 2 9例病理报告无癌转移的淋巴结 3715枚。应用单克隆抗细胞角蛋白 ( AE1/ AE3)、抗上皮细胞膜 ( EMA) ,及多克隆抗角蛋白抗体进行免疫组化染色重新检查。结果 所有病例的 32 .3% ( 113/ 350 )、被检淋巴结的 5.5%( 2 0 3/ 3715)有淋巴结内隐匿性肿瘤转移。肺癌患者及被检淋巴结的阳性率均比其他肿瘤高。肺鳞癌58%、腺癌 53.8%的淋巴结为阳性 ,分别比食管鳞癌 2 2 .5%、外阴鳞癌 10 .3%及乳腺癌 2 7.7%高 ( P<0 .0 5)。部分乳腺癌患者术后随访显示 :淋巴结阳性患者比阴性者预后更差 ( P<0 .0 5)。结论 说明免疫组化技术可大大提高淋巴结微小癌转移的检出率 ,其阳性率的不同可能与患者的临床经过甚至癌患者的死亡率相关联。 | 陈朝伦 卢晓梅 黄绒 黎音 古丽娜尔 沈宝茵 A J Cochran D R Wen W F Coulson | 1997 | 中华肿瘤杂志1997，19，1： | 16 |
| 2 | Mechanical Behaviour and Microstructure Evolution of Superplastic Mg-8.4 wt pct Li Alloy and Effect of Grain Size and Phase Ratio on Its Elongation显示文摘Mechanical properties and microstructure evolution of Mg-8.4 wt pct Li alloy have been investi- gated. The superplastic elongation-to-failure 920% at 573 K and initial strain rate of 5 × 10-4 s-1 at low nominal stress 2 MPa has been demonstrated. It was shown through optical microstructure that the average grain sizes at gauge length section before and after superplastic tension and at grip section were 7.5 μm, 31.7 μm and 20 μm respectively, indicating significant deformation induced grain growth and static grain growth. Comparison of experiment data with published data for superplastic Mg-Li alloys shows that fine grain size and about 50 to 50 phase ratio contribute to achieving the largest superplasticity. Some related research works in other alloys are compiled and further evidences to such theoretic argument are provided. | Cao, FR Cui, JZ Wen, JL Lei, F | 2000 | Journal of Materials Science & Technology2000，16，1： | 5 |
| 3 | Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility:A meta-analysis显示文摘AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) susceptibility.METHODS: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% conf idence intervals (95% CIs) for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32).CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC. | Yong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin YangYong-Gang Wei, Fei Liu, Bo Li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin Yang, Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Prov- ince, China Author contributions: Wei YG and Liu F designed the study, collected and analyzed the data and wrote the manuscript Li B collected and analyzed the data and wrote the manuscript Chen X and Ma Y collected and analyzed the data Yan LN analyzed the data and contributed to the discussion Wen TF and Xu MQ revised the manuscript Wang WT and Yang JY contributed to the discussion Wei YG and Liu F contributed equally to this work. | 2011 | World Journal of Gastroenterology2011，17，34： | 3 |
| 4 | Mechanical injury increases bFGF and CNTF mRNA expression in the mouse retina显示文摘 | Cao W Wen R Li F | 1997 | Exp Eye Res1997，65，： | 2 |
| 5 | Optimal bidding strategies and modelling of imperfect information among competitive generators显示文摘 | Wen F S David A K | 2001 | IEEE Transactions on Power System2001，16，1： | 2 |
| 6 | Adhesive joint design for high yield and low cost assembly of fiberoptic devices 显示文摘 | Lin Yaomin Liu Wenning Shi F G | 1992 | IEEE Circuits and Devices Magazine1992，8，6： | 2 |
| 7 | Optimal bidding strategies and modeling of imperfect information among competitive generators显示文摘 | Wen F S David A K | 2001 | IEEE Trans on Power Systems2001，16，1： | 2 |
| 8 | Synthesis and electroluminescence properties of europium (Ⅲ) complexes with new second ligands 显示文摘 | Liu Z Wen F S Li W L | 2005 | Thin Solid Films2005，478，12： | 1 |
| 9 | Relationship between water chemistry and the distribution of the endangered aquatic quillwort Isotes sinensis Palmer in China显示文摘 | Wen M Z Pang X A Wang Q F | 2003 | Journal of Freshwater Ecology2003，18，3： | 1 |
| 10 | A new approach to fault section estimation in power systems using ant system显示文摘 | Tian L Wen F S | 1999 | Electric Power System Research1999，41，： | 1 |
| 11 | Market power in electricity supply显示文摘 | David A K Wen F S | 2001 | IEEE Transactions on Energy Conversation2001，16，4： | 1 |
| 12 | Effect of pore structure on Ni catalyst for CO2 reforming of CH4显示文摘 | SUN N WEN X WANG F WEI W SUN Y | 2010 | Energy Environ Sci2010，3，3： | 1 |
| 13 | Tanshinone lI A acts via p38 MAPK to induce apoptosis and the down-regulation of ERCC1 and lung-resistance protein in cisplatin-resistant ovarian cancer ceils 显示文摘 | Jiao JW Wen F | 2011 | Oncol Rep2011，25，3： | 1 |
| 14 | Optimal bidding strategies for competitive generators and large consumers 显示文摘 | Wen F David A | 2001 | Electrical Power and Energy Systems2001，，23： | 1 |
| 15 | High capacity silicon/carbon composite anode materials for lithium ion batteries显示文摘 | Wen Z S Yang J Wang B F | 2003 | Electrochemistry Communications2003，5，2： | 1 |
| 16 | TH2Cytokine-enhanced and TGF-beta-enhanced vascular endothelial growth factor production by cultured human airway smooth muscle cells is attenuated by IFNgamma and corticosteroids显示文摘 | Wen F Q Liu X Manda W | 2003 | J Allergy Clin Immunol2003，111，6： | 1 |
| 17 | Conjectural variation based bidding strategy in spot markets: fundamentals and comparison with classical game theoretical bidding strategies显示文摘 | Song Y Q Ni Y X Wen F S | 2003 | Electric Power Systems Research2003，67，1： | 1 |
| 18 | Continuous measurement of water vapor 180/160 and 2H/IH isotope ratios in the atmosphere显示文摘 | Wen X F Sun X M Zhang S C | 2008 | Journal of Hydrology2008，349，34： | 1 |
| 19 | New insights into atypicalparkinsonism显示文摘 | Wenning GK Krismer F Poewe W | 2011 | Curr Opin Neurol2011，24，4： | 1 |
| 20 | Changes in serum adiponectin con- centrations and endothelial function after intensive insulin treat- ment in people with newly diagnosed type 2 diabetes: A pilot study显示文摘 | Li F Zhao T Y Wen X R | 2011 | Original Research Article Diabetes Research and Clini-cal Practice2011，94，2： | 1 |
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