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| 1 | Long-term follow-up after complete ablation of Barrett's esophagus with argon plasma coagulation显示文摘AIM: To report the long-term outcome of patients after complete ablation of non-neoplastic Barrett's esophagus (BE) with respect to BE relapse and development of intraepithelial neoplasia or esophageal adenocarcinoma.METHODS: In 70 patients with histologically proven nonneoplastic BE, complete BE ablation was achieved by argon plasma coagulation (APC) and high-dose proton pump inhibitor therapy (120 mg omeprazole daily). Sixty-six patients (94.4%) underwent further surveillance endoscopy. At each surveillance endoscopy four-quadrant biopsies were taken from the neo-squamous epithelium at 2 cm intervals depending on the pre-treatment length of BE mucosa beginning at the neo-Z-line, and from any endoscopically suspicious lesion.RESULTS: The median follow-up of 66 patients was 51 mo (range 9-85 mo) giving a total of 280.5 patient years.A mean of 6 biopsies were taken during surveillance endoscopies. In 13 patients (19.7%) tongues or islands suspicious for BE were found during endoscopy. In 8 of these patients (12.1%) non-neoplastic BE relapse was confirmed histologically giving a histological relapse rate of 3% per year. In none of the patients, intraepithelial neoplasia nor an esophageal adenocarcinoma was detected.Logistic regression analysis identified endoscopic detection of islands or tongues as the only positive predictor of BE relapse (P = 0.0004).CONCLUSION: The long-term relapse rate of nonneoplastic BE following complete ablation with high-power APC is low (3% per year). | Ahmed Madisch Stephan Miehike Ekkehard Bayerdoerffer Birgit Wiedemann David Antos Anke Sievert Michael Vieth Manfred Stolte Heinrich Schulz | 2005 | World Journal of Gastroenterology2005，11，8： | 14 |
| 2 | 马克斯·普朗克创新与竞争研究所就欧盟委员会“关于构建欧洲数据经济征求意见书”的立场声明显示文摘马克斯·普朗克创新与竞争研究所是一家在马克斯·普朗克学会之下设立的研究机构,自五十一年前设立以来,一直致力于在既已确立的科学原理基础之上对知识产权和竞争法的分析与发展进行研究.马克斯·普朗克创新与竞争研究所承担着该领域内基础问题的研究.基于其卓著的研究贡献,马克斯·普朗克创新与竞争研究所发起并引领着德国、欧洲以及国际层面重要的立法及理论研究。 | Josef Drexl Reto M.Hilty Jure Globocnik Franziska Greiner Daria Kim Heiko Richter Peter R.Slowinski Gintar? Surblyt? Axel Walz Klaus Wiedemann 刘维 张嘉莹 | 2017 | 电子知识产权2017，，7： | 11 |
| 3 | Rck of Salmonella enterica, subspecies enterica serovar Enteritidis, mediates Zipper-like internalization显示文摘沙门氏菌能通过它的类型 III 分泌物系统(T3SS-1 ) 入侵非吞噬细胞的房间,它导致一个扳机入口过程。这研究显示出那沙门氏菌 enterica,亚种 enterica serovar Enteritidis 能也经由 Rck 外部膜蛋白质入侵房间。Rck 必要、足够启用非侵略的 E。coli 和 Rck 涂的祷告遵守并且入侵不同房间。与不同 Rck 肽涂的乳胶祷告的成为主观分析证明包含氨基酸 140-150 的肽支持了粘附,而在 150 和 159 之间的氨基酸调制了侵略。主导否定的衍生物的表示和特定的禁止者的使用在激活 Arp2/3 建筑群触发充满肌动朊的累积的形成表明了小 GTPases Rac1 和 Cdc42 的关键角色,导致 Rck 依赖的成为主观。最后,扫描并且有 Rck 涂的祷告和 E 的传播电子显微镜学。表示 Rck 的 coli 揭示了形成了像拉链的结构的象 microvillus 一样延期,吞没支持者祷告和细菌。总的来说,我们的结果提供新卓见进沙门氏菌 T3SS 独立的侵略机制并且强烈建议 Rck 导致像拉链的入口机制。因而,沙门氏菌似乎是发现能导致拉链和扳机机制入侵宿主细胞的第一个细菌。 | Manon Rosselin Isabelle Virlogeux-Payant Christian Roy Elisabeth Bottreau Pierre-Yves Sizaret Lily Mijouin Pierre Germon Emmanuelle Caron Philippe Velge Agnes Wiedemann | 2010 | Cell Research2010，20，6： | 4 |
| 4 | Different modes of foveal regeneration after closure of full-thickness macular holes by(re)vitrectomy and autologous platelet concentrate显示文摘AIM: To describe using spectral-domain optical coherence tomography the regeneration of the foveal morphology after pars plana(re)vitrectomy surgery and gas tamponade combined with injection of autologous platelet concentrate to treat full-thickness macular holes, and to describe different anatomical outcome. METHODS: A retrospective case series of 8 eyes of 8 patients was described. RESULTS: In all cases investigated, the plateletassisted closure of macular holes was associated with a rapid resolution of cystic cavities in the foveal walls. In two patients, there was a regular regeneration of the foveal morphology after hole closure;the regenerated central fovea had a regular structure with a foveola and photoreceptors. In three other patients, there was an irregular regeneration of the fovea;a foveola was not formed, photoreceptor cells were absent from the foveal center, and the center was composed of Müller and retinal pigment epithelial(RPE) cells. The foveal regeneration after hole closure may proceed with or without a temporary detachment of the foveal center from the RPE, and with or without a direct contact between the central outer nuclear layer(ONL) and the RPE. Contacts between the ONL and RPE were observed only in patients with an irregular foveal regeneration after hole closure.CONCLUSION: The data show that there are different modes of foveal regeneration after closure of macular holes with(re)vitrectomy and platelet concentrate. It is suggested that the regular regeneration of the foveal morphology proceeds by Müller cell-mediated tissue movements without cell proliferation, whereas the irregular foveal regeneration proceeds in part by proliferation of Müller and RPE cells. | Andreas Bringmann Claudia Jochmann Jan Darius Unterlauft Renate Wiedemann Matus Rehak Peter Wiedemann | 2020 | International Journal of Ophthalmology(English edition)2020，13，1： | 3 |
| 5 | 糖基化终产物对脉络膜微血管内皮细胞增生和管腔形成的影响(英文)显示文摘目的:研究糖基化终产物(advanced glycationendproducts, AGEs)在年龄相关性黄斑变性发生中的作用。方法:使用lycopersiconesculentum agglutinin包被磁珠的改良方法分离牛脉络膜微血管内皮细胞(bovine choroidalendothelialcells, CEC),采用抗VIII因子免疫细胞化学法和摄取低密度脂蛋白(dil-acetylated low-density lipoprotein,dil-ac-LDL)法进行细胞鉴定。将50g/L牛血清白蛋白和150g/L葡萄糖在37℃孵育6wk 以制备AGEs,通过抗-AGEs 抗体点杂交法定性分析。用MTT 法(3,(4,5-dimethylthiazol-2-yl)-2,5- diphenyl te-trazolium bromide assay)测定CEC 增生,用Vit-rogen凝胶系统观察管腔形成情况。结果:培养细胞中90%以上呈因子阳性,并具有摄取dil-ac-LDL的能力,表明具有内皮细胞的特征。制备的AGEs 与抗-AGEs 抗体具有亲和力。浓度在62.5~500mg/L范围内的AGEs 处理CEC 3d 后,细胞增生呈剂量依赖性增加。碱性成纤维细胞生长因子(basic fibroblastgrowth factor, bFGF)可明显增强CEC 中管腔样结构的形成(P <0.05),但500mg/L和50mg/L的AGEs 对CEC 管腔形成无明显影响(P >0.05)。结论:AGEs 可以促进CEC 的增生,但对其管腔形成无影响。提示AGEs 通过增强CEC 增生,可能是渗出型AMD 发病中潜在的启动因子之一? | 王雨生 Ulrike Friedrichs Wolfram Eichler Stephan Hoffmann Peter Wiedemann | 2005 | 国际眼科杂志2005，5，2： | 3 |
| 6 | 眼科学人工智能显示文摘人工智能(AI)是指计算机模拟人类的智力推理、决策和行为。AI已经在各个医学领域得到了应用。由于AI高度依赖于眼成像技术和视觉数据,在眼科已显示出巨大潜力。AI的总体潜能包括筛查、诊断分级,自动检测疾病活动、复发、治疗效果量化,以及确定新疗法的相关靶点,使个性化医疗和大规模管理成为可能。本文简要介绍和评论AI在眼科中的主要应用,包括糖尿病视网膜病变、年龄相关性黄斑变性、青光眼、白内障,远程医疗以及相关主题,并提出了AI在临床实践中面临的机遇和挑战,包括临床和技术的挑战、数据质量、算法结果的可解释性、医学法律以及伦理问题等。 | Peter Wiedemann 惠延年(译) | 2023 | 国际眼科杂志2023，23，9： | 2 |
| 7 | Role of apoptosis in the cytotoxic effect mediated by daunorubicin in cultured human retinal pigment epithelial cells 显示文摘 | Wang YS Hui YN Wiedemann P | 2002 | J Ocul Pharm Ther2002，18，4： | 2 |
| 8 | 视网膜病中的生长因子显示文摘此综述的目的是提供生长因子与眼后部疾病的明确关系。生长因子能够结合到特定的细胞表面受体上,单独或协同地做为多功能信号来调节细胞的生长和增殖。它们对细胞的生物作用包括:细胞粘连、移行、生存、分化、细胞外基质分泌、蛋白酶和蛋白酶抑制剂释放、其它生长活动的产生和血管生成。生长因子使细胞和微环境联系起来。因为一些生长因子是损伤修复和血管生成的可溶性介质,因此,增殖性玻璃体视网膜病变(PVR)和增殖性糖尿病性视网膜病变(PDR)可能都由这些因子引起和加重,其它因子作为生存因子,能够防止视网膜变性。生长因子的多功能特性使它有可能在未来投入实际应用。 | Peter Wiedemann 郑荣领 | 1993 | 国外医学(眼科学分册)1993，17，1： | 2 |
| 9 | Role of retinal glial cells in neurotransmitter uptake and metabolism显示文摘 | Andreas Bringmann Thomas Pannicke Bernd Biedermann Mike Francke Ianors Iandiev Jens Grosche Peter Wiedemann Jan Albrecht Andreas Reichenbach | 2008 | Neurochemistry International2008，，3： | 2 |
| 10 | Müller cells in the healthy and diseased retina显示文摘 | Andreas Bringmann Thomas Pannicke Jens Grosche Mike Francke Peter Wiedemann Serguei N. Skatchkov Neville N. Osborne Andreas Reichenbach | 2006 | Progress in Retinal and Eye Research2006，，4： | 2 |
| 11 | MMP-2 and MMP-9 secretion by rpe is stimulated by angiogenic molecules found in choroidal neovascular membranes 显示文摘 | Hoffmann S He S Ehren M Ryan S J Wiedemann P Hinton DR | 2006 | Retina2006，26，4： | 1 |
| 12 | Vapor Pressure Determination by Pressure DSC显示文摘 | Boller A Wiedemann H G | 1998 | J Thermal Anal1998，53，： | 1 |
| 13 | Small intestinal submucosa for pubourethral sling suspension for the treatment of stress incontinence: first histopathological results in humans显示文摘 | Wiedemann A Otto M | 2004 | J Urol2004，172，1： | 1 |
| 14 | Systemic hyperthermia and ICE chemotherapy for sarcoma patients:rationale and clinical status 显示文摘 | Wiedemann G J Robins H I Katschinski D M | 1997 | Anticancer Res1997，17，4： | 1 |
| 15 | Healthcare systems--an inter- national review: an overview显示文摘 | Lameire N Joffe P Wiedemann M | 1999 | Nephrol Dial Transplant1999，14，6： | 1 |
| 16 | Use of sedatives, opioids, and neuromuscular blocking agents in patients with acute lung injury and acute respiratory distress syndrome显示文摘 | Alejandro C. Arroliga B Taylor Thompson Marek Ancukiewicz Jeffrey P. Gonzales Kalpalatha K. Guntupalli Pauline K. Park Herbert P. Wiedemann Antonio Anzueto | 2008 | Critical Care Medicine2008，，4： | 1 |
| 17 | Characteristics of PVD-coatings on AZ31hp magnesium alloys显示文摘 | Frank Hollstein Renate Wiedemann Jana Scholz | 2003 | Surface and Coatings Technology2003，，162： | 1 |
| 18 | Pigment epithelium-derived factor acts as an opponent of growth-stimulatory factors in retinal glial-endothelial cell interactions显示文摘 | Yafai Y Lange J Wiedemann P | 2007 | Glia2007，55，6： | 1 |
| 19 | Operative treatment of greater tuberosity fractures of the humerus-A biomechanical analysis 显示文摘 | Braunstein V Wiedemann E Plitz W | 2007 | Clinical Biomechanics2007，22，： | 1 |
| 20 | Downregulation of the CXC chemokine receptor 4/stromal cel -derived factor 1 pathway enhances myocardial neovascularization,cardiomyocyte survival,and functional recovery after myocardial infarction显示文摘 | Bonaros N Sondermeijer H Wiedemann D | | 0，，03： | 1 |
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