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| 1 | Tumor Antigen Specific Activation of Primary Human T-Cells Expressing a Virally Encoded Chimeric T-Cell Receptor Specific for p185HER2显示文摘We have developed and tested chimeric T-cell receptors (TCR) specific for p185HER2. In these experiments, retroviral vectors expressing the N29γ or N29ζ receptors were constructed in pRET6. Amphotropic viral producer cells were established in the GALV-based PG13 packaging cell line. Ficoll purified human peripheral blood lymphocytes (PBL) were virally transduced using an optimized protocol incorporating activation with immobilized anti-CD3/anti-CD28 monoclonal anti- bodies, followed by viral infection in the presence of fibronectin fragment CH296. Transduced cells were co-cultured with human tumor cell lines that overexpress (SK-OV-3) or underexpress (MCF7) p185HER2 to assay for antigen specific im- mune responses. Both CM+ and CD8+ T-cells transduced with the N29γ or N29ζ chTCR demonstrated HER2-specific anti- gen responses, as determined by release of Th1 like cytokines, and cellular cytotoxicity assays. Our results support the fea- sibility of adoptive immunotherapy with genetically modified T-cells expressing a chTCR specific for p185HER2. | 杨建民 Michael S FRIEDMAN Christopher M REYNOLDS Marianne T HUBEN Lee WILKE Jennifer FULLER 李桥 Zelig ESHHAR James J MULE Kevin T MCDONAGH | 2004 | Journal of Microbiology and Immunology2004，2，4： | 5 |
| 2 | Combined compression-torsion buckling test of laminated composite cylindrical shells显示文摘 | Wilking D J Love T S | 1974 | AIAA1974，12，3： | 2 |
| 3 | 显示文摘 | Vick Roy T B Blanch H W Wilke C R | 1983 | Trends of Biotecnology1983，1，： | 1 |
| 4 | The genus Adriohydrobia(Hydrobiidae Gastropoda) : polytypic species or polymorphic populations? 显示文摘 | Wilke T Falniowski A | 2001 | Journal of Zo- ological Systematics and Evolutionary Research2001，39，： | 1 |
| 5 | Industrial bioeonyersion of renew- able resources as an alternative to conventional chem- istry 显示文摘 | WILKE T RLOP K | 2004 | Appi Microbiol Biotecimol2004，66，2： | 1 |
| 6 | Developing Porphyra/salmon integrated aquaculture for bioremediation and diversi- fication of the aquaculture industry 显示文摘 | Chopin T Yarish C Wilkes R | 1999 | Journal of Applied Phycology1999，11，5： | 1 |
| 7 | Sub-terahertz on-off switch based on a two-dimensional photonic crystal infil- trated by liquid crystals 显示文摘 | Ghattan Z Hasek T Wilk R | 2008 | Optics Communications2008，281，18： | 1 |
| 8 | Radiotherapy in the management of brain metastases from breast cancer显示文摘 | Fokstuen T Wilking N Rutqvist LE | | 0，，01： | 1 |
| 9 | Optimization and profling of the cache performance of parallel lattice Boltzmann codes 显示文摘 | POHL T KOWARSCHIK M WILKE J IGLBERGER K RUDE U | 2003 | Parallel Process Letters2003，13，4： | 1 |
| 10 | Development of resistence against amproloum,nicbarzin,maduramysin,lasalocid and maxiban显示文摘 | Tamas T Schkeim K D Wilks G | 1991 | J Parasitol1991，，： | 1 |
| 11 | Energetic proton generation in ultra-intense laser solid interactions显示文摘 | Wilks S C Langdon A B Cowan T E | 2001 | Phys Plasma2001，8，2： | 1 |
| 12 | Energetic proton generation in ultra-intense laser-solid interactions显示文摘 | Wilks S C Langdon A B Cowan T E | 2001 | Phys Plasmas2001，8，2： | 1 |
| 13 | Characterization and com- parison of polyurethane networks prepared using soybean-based poly- ols with varying hydroxyl content and their blends with petroleum- based polyols显示文摘 | Pechar T W Sohn S Wilkes G L | 2006 | Journal of Applied Polymer Science2006，101，： | 1 |
| 14 | 显示文摘 | Carlin R T Wilkes J S | 1990 | J Mol Catal1990，63，2： | 1 |
| 15 | Treatment-dependent and treat- ment-independent risk factors associated with the risk of diabetes-re- lated events: a retrospective analysis based on 229,042 patients with type 2 diabetes mellitus显示文摘 | Wilke T Mueller S Groth A | 2015 | Cardiovasc Diabetol2015，14，： | 1 |
| 16 | On the design of coating systems: metallurgical and other considerations 显示文摘 | SUBRAMANIAN C STRAFFORD K N WILKS T P etal | 1996 | Journal of Materials Processing Technology1996，56，： | 1 |
| 17 | Scapular dyskinesis and its relation to shoulder injury显示文摘 | Kibler WB Sciascia A Wilkes T | 2012 | J Am Acad Orthop Surg2012，20，6： | 1 |
| 18 | Genetic variation at the alcoholdehydrogenase locus in Drosophila melanogaster in relation to envi-ronmental variation:ethanol levels in breeding sites and allozymefrequencies显示文摘 | Gibson J B May T W Wilks A V | 1981 | Oecologia1981，51，2： | 1 |
| 19 | Anaerobic degradation of p - ethylphenol by 'Aromatoleum aromaticum' strain EbN1 : pathway, regulation, and involved proteins 显示文摘 | W'HLBRAND L WILKES H HALDER T | 2008 | Journal of Bacteriology2008，190，16： | 1 |
| 20 | Exercise capacity in pediatric patients with inflammatory bowel disease显示文摘 | Ploeger H E Takken T Wilk B | 2011 | J Pediatr2011，158，5： | 1 |
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