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| 1 | 在血压控制不良的高血压患者中使用数字化干预的家庭和在线血压管理:随机对照试验显示文摘HOME BP试验(The home and online management and evaluation of blood pressure)的目的是评估在初级预防中结合自我监测和自我管理的数字化干预在高血压管理中的作用。研究者纳入英国76个治疗中心经过治疗但血压控制不好(>140/90 mm Hg, 1 mm Hg=0.133 kPa)并能上网的患者622例,进行自动确定主要终点的公开随机对照试验。 | McMa-nus RJ Little P Stuart B Morton K Raftery J Kelly J Bradbury K Zhang J Zhu S Murray E May CR Mair FS Michie S Smith P Band R Ogburn E AllenJ Rice C Nut-tall J Williams B Yardley L 陈嘉睿(译) 叶鹏(审校) | 2021 | 中华高血压杂志2021，29，5： | 15 |
| 2 | Operative complications and economic outcomes of cholecystectomy for acute cholecystitis显示文摘BACKGROUND Recent management of acute cholecystitis favors same admission(SA)or emergent cholecystectomy based on overall shorter hospital stay and therefore cost savings.We adopted the practice of SA cholecystectomy for the treatment of acute cholecystitis at our tertiary care center and wanted to evaluate the economic benefit of this practice.We hypothesized that the existence of complications,particularly among patients with a higher degree of disease severity,during SA cholecystectomy could negate the cost savings.AIM To compare complication rates and hospital costs between SA vs delayed cholecystectomy among patients admitted emergently for acute cholecystitis.METHODS Under an IRB-approved protocol,complications and charges for were obtained for SA,later after conservative management(Delayed),or elective cholecystectomies over an 8.5-year period.Patients were identified using the acute care surgery registry and billing database.Data was retrieved via EMR,operative logs,and Revenue Cycle Operations.The severity of acute cholecystitis was graded according to the Tokyo Guidelines.TG18 categorizes acute cholecystitis by Grades 1,2,and 3 representing mild,moderate,and severe,respectively.Comparisons were analyzed withχ2,Fisher’s exact test,ANOVA,ttests,and logistic regression;significance was set at P<0.05.RESULTS Four hundred eighty-six(87.7%)underwent a SA while 68 patients(12.3%)received Delayed cholecystectomy.Complication rates were increased after SA compared to Delayed cholecystectomy(18.5%vs 4.4%,P=0.004).The complication rates of patients undergoing delayed cholecystectomy was similar to the rate for elective cholecystectomy(7.4%,P=0.35).Mortality rates were 0.6%vs 0%for SA vs Delayed.Patients with moderate disease(Tokyo 2)suffered more complications among SA while none who were delayed experienced a complication(16.1%vs 0.0%,P<0.001).Total hospital charges for SA cholecystectomy were increased compared to a Delayed approach($44500±$59000 vs$35300±$16700,P=0.019).The relative risk of developing a complication was 4.2x[95%confidence interval(CI):1.4-12.9]in the SA vs Delayed groups.Among eight patients(95%CI:5.0-12.3)with acute cholecystitis undergoing SA cholecystectomy,one patient will suffer a complication.CONCLUSION Patients with Tokyo Grade 2 acute cholecystitis had more complications and increased hospital charges when undergoing SA cholecystectomy.This data supports a selective approach to SA cholecystectomy for acute cholecystitis. | Christopher P Rice Krishnamurthy B Vaishnavi Celia Chao Daniel Jupiter August B Schaeffer Whitney R Jenson Lance W Griffin William J Mileski | 2019 | World Journal of Gastroenterology2019，25，48： | 8 |
| 3 | 多糖和寡糖的体外发酵特性及其对鸡盲肠微生物菌群的影响显示文摘本研究采用体外累积发酵产气法和16SrDNA指纹图谱鉴定技术研究了来自香菇、银耳和黄芪的天然免疫活性多糖(LenE,TreE和AstE)及酵母胞壁甘露寡糖(MOS)对鸡肠道微生物菌群及其发酵特性的影响。结果表明,三种多糖提取物的总糖含量均占干物质的60%以上,而MOS总糖含量在90%以上。多糖和寡糖具有不同的发酵模式;MOS、AstE和LenE三种糖的发酵模式相似,呈一阶段发酵模式;TreE呈两阶段的发酵模式。三种糖中,MOS和AstE发酵速度较TreE快。MOS和AstE在发酵后总VFA产量最高,pH最低;黄芪多糖发酵后产生较多的直链脂肪酸和较低的氨。这些多糖和寡糖提取物影响肠道微生物的活性和组成成分,体现在发酵模式和发酵终产物的显著改变上。以上研究结果表明,来自香菇、银耳和黄芪的天然免疫活性多糖(LenE,TreE和AstE)及酵母胞壁甘露寡糖(MOS)在体外发酵后,均具有显著改变鸡盲肠微生物发酵终产物的含量和盲肠微生物活性的作用。 | 李万坤 郭福存 赵兴绪 Williams B A Kwakkel R P Verstegen M W A | 2007 | 动物营养学报2007，19，3： | 5 |
| 4 | Volumetric Analysis Predicts Hepatic Dysfunction in Patients Undergoing Major Liver Resection显示文摘 | Margo Shoup Mithat Gonen Michael D’Angelica William R Jarnagin Ronald P DeMatteo Lawrence H Schwartz Scott Tuorto Leslie H Blumgart Yuman Fong | 2003 | Journal of Gastrointestinal Surgery2003，，3： | 2 |
| 5 | Fine-tuning of the innate immune response by microRNAs显示文摘 | Gantier M P Sadler A J Williams B R | 2007 | lmmunol Cell Biol2007，，6： | 1 |
| 6 | Simulation of the performance of electrical capacitance tomography for muasurement of dense phase pneumatic conveying显示文摘 | K L Ostrowski S P Luke R A Williams | 1997 | Chemical Engineering Journal1997，，6： | 1 |
| 7 | Semaphorin 4D provides a link between axon guidance processes and tumorinduced angiogenesis显示文摘 | Basile J R Castilho R M Williams V P | 2006 | Proc Natl Acad Sci USA2006，103，24： | 1 |
| 8 | Rubber - thermoplastic compositions显示文摘 | Coran A Y Patel R P Williams D | 1982 | Rubber Chem Technol1982，55，： | 1 |
| 9 | Ultrasound guidance speeds execution and improves the quality of supraclavicular block显示文摘 | WILLIAMS S R CHOUINARD P ARCAND G | 2003 | Anesth Analg2003，97，5： | 1 |
| 10 | Nm23/nucleoside diphosphate kinase:toward a structural and biochemical understanding of its bio logical functions显示文摘 | de la Rosa A Williams R L Steeg P S | 1995 | Bioessays1995，17，1： | 1 |
| 11 | New cytotoxic salinosporamides from the marine actinomycete Salinispora tropica显示文摘 | Williams P G Buchanan G O Feling R H | 2005 | J Org Chem2005，70，16： | 1 |
| 12 | Small rat islets are superior to large islets in in vitro function and in transplantation outcomes 显示文摘 | MacGregor R R Williams S J Tong P Y | 2006 | Am J Physiol Endocrinol Metab2006，290，5： | 1 |
| 13 | Predictors and patterns of recurrence after resection of hepatocellular carcinoma显示文摘 | Charles Cha Yuman Fong William R Jarnagin Leslie H Blumgart Ronald P DeMatteo | 2003 | Journal of the American College of Surgeons2003，，5： | 1 |
| 14 | A modeling ap proach to determining the relationship between erosion and productivity显示文摘 | WILLIAMS J R JONES C A DYKE P T | 1984 | Transactions of the ASAE1984，27，1： | 1 |
| 15 | One-step synthesis of polyhedral silsesquioxanes bearing bulky substituents: UV-MALDI-TOF and ESI- TOF mass spectrometry characterization of reaction prod- ucts 显示文摘 | FASCE D P WILLIAMS R J J ERRA-BALSELLS R | 2001 | Macromolecules2001，34，： | 1 |
| 16 | Researchers' e-journal use and information seeking behavior显示文摘 | Nicholas D Williams P Rowlands I Jamali H R | 2010 | Journal of Information Science2010，，36： | 1 |
| 17 | Anglnex synergizes with radiation therapy to inhibit tumor growth by radiosensitizing endothelial cells显示文摘 | Dings R P Williams B W Song C W | 2005 | Int J Cancer2005，115，2： | 1 |
| 18 | Poly (silsesquioxanes) derived from the hydrolytic condensation of organotrialkoxysilanes containing hydroxyl groups显示文摘 | DELL ERBA I E FASCE D P WILLIAMS R J J | 2003 | J Organomet Chem2003，686，： | 1 |
| 19 | New cytotoxic salinosporamides from the marine actinomycete Salinispora tropica 显示文摘 | Williams P G Buchanan G O Feling R H | 2005 | J Org Chem2005，70，16： | 1 |
| 20 | Chemical anal-ysis of contaminated soil strengthened by the addition of lime显示文摘 | Mckinley J D Thomas H R Williams K P | 2001 | Engineering Geology2001，60，： | 1 |
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