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200篇 您的检索式：作者名="WINTER J O"

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	题名	作者	年代	出处	被引量
1	Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury.	Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon	2005	Hepatobiliary & Pancreatic Diseases International2005，4，1：	12
2	Will advanced lithiumalloy anodes have a chance in lithium-ion batteries 显示文摘	BESENHARD J O YANG J WINTER M	1997	J Power Sources1997，68，：	2
3	A rat model of bone cancer pain显示文摘	S.J Medhurst K Walker M Bowes B.L Kidd M Glatt M Muller M Hattenberger J Vaxelaire T O’Reilly G Wotherspoon J Winter J Green L Urban	2002	Pain2002，，：	2
4	Advances in battery technology:recharge able magnesium batteries and novelnegative-electrode mater ials for lithium ion batteries 显示文摘	BESENHARD J O WINTER M	2002	Chemphyschem2002，3，：	2
5	Cyclic and acyclic sulfites: new solvents and electrolyte additives for lithium ion batteries with graphitic anodic显示文摘	WRODNIGG G H BESENHARD J O WINTER M	2001	Journal of Power Sources2001，9798，：	1
6	Electrochemical lithiation of tin and tin-based intermetallics and composites显示文摘	Winter M Besenhard J O	1999	Electrochim Acta1999，45，12：	1
7	Electrochemical lithiation of tin and tin - based intermetallics and composites 显示文摘	Winter M Besenhard J O	1999	Electrochim Acta1999，45，：	1
8	Insertion electrode materials for rechargeable lithium batteries 显示文摘	Winter M Besenhard J O Sphar MS	1998	Advanced Materials1998，10，：	1
9	Electrochemical Iithiation of tin and tin-based intermetallics and composites显示文摘	Winter M Besenhard J O	1999	Electrochim Acta1999，45，12：	1
10	Tin and tin-based intermetallics as new anode materials for lithium-ion cells显示文摘	Wachtler M Besenherd J O Winter M	2001	J Power Sources2001，94，2：	1
11	Sentinel lymph nodemapping in colorectal cancer 显示文摘	Mulsow J Winter DC O' Keane JC	2003	Br J Surg2003，90，6：	1
12	Insertion electrode materials for rechargeable lithium batteries显示文摘	Winter M Besenhard J O Sphar M S	1998	Advanced Materials1998，10，10：	1
13	Electrochemical lithiation of fin and tin-based intermetallics and composites显示文摘	WINTER M BESENHARD J O		0，，：	1
14	Will advanced lithium-alloy anodes have a chance in lithium-ion batteries显示文摘	BESENHARD O J YANG J WINTER M		0，，01：	1
15	Insertion electrode materials for rechargeable lithium batteries 显示文摘	WINTER M BESENHARD J O SPAHR M E	1998	Adv Mater1998，10，：	1
16	Insertion electrode materials for rechargeable lithium batteries 显示文摘	WINTER M BESENHARD J O SPAHR M E NOV K P	1998	Advanced Materials1998，10，10：	1
17	Insertion elec- trode materials for rechargeable lithium batteries 显示文摘	WINTER M BESENHARD J O SPAHR M E	1998	Adv Mater1998，10，10：	1
18	显示文摘	Winter M Besenhard J O	1999	Electrochem Acta1999，45，：	1
19	Insertion electrode materials for rechargeable lithium batteries显示文摘	Winter M Besenhard J O Spahr M E	1998	Advanced Materials1998，10，10：	1
20	Inser- tion electrode materials for lithium batteries 显示文摘	WINTER M BESENHARD J O SPAHR M E	1998	Advance Ma-terials1998，10，10：	1

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