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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | A 12-week,open trial of donepezil hydrochloride in patients with multiple sclerosis and associated cognitive impairments显示文摘 | Tariot PN Wishart H | 2000 | J Clin Psychopharmacol2000，20，： | 1 |
| 3 | Viscocanalostomy and deep sclerectomy for the surgical treatment of glaucoma: a longterm follow-up显示文摘 | Wishart PK Wishart MS Porooshani H | 2003 | Acta Ophthalmol Scand2003，81，4： | 1 |
| 4 | Retinoid -inde- pendent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state 显示文摘 | Patani R Hollins A J Wishart TM | 2011 | Nat Com- mun2011，2，： | 1 |
| 5 | Non-penetrating glaucoma surgery augmented with mitomycin C or 5-fluorouracil in eyes at high risk of failure of filtration surgery: long-term results显示文摘 | Choudhary A Wishart P K | 2007 | Clin Experiment Ophthalmol2007，35，： | 1 |
| 6 | Gastric and oesophageal emptying in patients with type 2 (non-insulin-depeadent) diabetes mellitus显示文摘 | Horowitz M Harding PE Maddox AF Wishart JM | 1989 | Diabetologia1989，32，3： | 1 |
| 7 | Flicker perimetry using a luminance threshold strategy at frequencies from 5- 25Hz in glaucoma, ocular hypertension and normal controls 显示文摘 | Austin MW 0' Brien CJ Wishart PK | 1994 | Curr Eye Res1994，13，10： | 1 |
| 8 | Long-term results of viscocanalostomy in pseudoexfoliative and primary open angle glaucoma显示文摘 | Wishart PK Wishart MS Choudhary A | | 0，，： | 1 |
| 9 | Discovering drug targets through the web显示文摘 | Wishart D S | | 0，，： | 1 |
| 10 | Merging the metaphors for organizational improvement:business process reengineering as a component of organizational learning显示文摘 | ROBEY D WISHART N A RODRIGUEZ-DIAZ A G | 1995 | Accounting Management and Information Technologies1995，5，1： | 1 |
| 11 | A feasibility study ( ICG-10) of indocyanine green ( ICG) fluorescence mapping for sentinellymph node detection in early breast cancer显示文摘 | Wishart GC Loh SW Jones L | 2012 | Eur J Surg On-col2012，38，8： | 1 |
| 12 | ApoE isoform- specific regulation of regeneration in the peripheral nervous system显示文摘 | Comley LH Fuller HR Wishart TM | 2011 | Hum MolGenet2011，20，12： | 1 |
| 13 | The effect of pH on the motility of spermatozoa from chicken, turkey and quail显示文摘 | Lena Holm Graham J. Wishart | 1998 | Animal Reproduction Science1998，，1： | 1 |
| 14 | Use of a liposome antigen delivery system to alter immune responses in vivo显示文摘 | Sosnowski DL Wishart DS | 1998 | JPharmSci1998，87，11： | 1 |
| 15 | Mitochondrial DNA differences distinguishing Meloidogyne mayaguensis from the major species of tropical root-knot nematodes显示文摘 | Blok V C Wishart J Fargette M | 2002 | Nematology2002，4，7： | 1 |
| 16 | 1H,13C and 15N chemical shift referencing in biomoleeular NMR 显示文摘 | Wishart D S Bigam C G Yao J | 1995 | J Biomol NMR1995，6，2： | 1 |
| 17 | Metabolomics: applications to food scienc and nutrition research 显示文摘 | Wishart D S | 2008 | Trends in Food Science & Technology2008，19，9： | 1 |
| 18 | Specific probesefficiently distinguish root-knot nematode species using signaturesequence in the ribosomal intergenetic spacer显示文摘 | Peterson D J Zijlstra C Wishart J | 1997 | Fundamental andApplied Nematology1997，，20： | 1 |
| 19 | Patient and tumour characteristics, management, and age-specific survival in women with breast cancer in the East of England显示文摘 | All AM Greenberg D Wishart GC | 2011 | Br J Cancer2011，104，4： | 1 |
| 20 | Isotretinoin 5 mg daily for low-grade adult acne vulgaris-A placebo-controlled, randomized double-blind study 显示文摘 | Rademaker N Wishart JM Birchall NM | 2014 | J Eur Acad Dermatol Venereol2014，28，6： | 1 |
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