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| 1 | Triggers of histologically suspected drug-induced colitis显示文摘BACKGROUND Drug toxicity is a common and even serious problem in the gastrointestinal tract that is thought to be caused by a broad spectrum of agents.Although withdrawal of the causative agent would cure the disease knowledge is scarce and mostly derives from case reports and series.AIM To investigate potential triggers of drug-induced colitis(DiC).METHODS We conducted a retrospective,observational case control study.Patients were assigned to DiC or one of two age-and gender-matched control groups(noninflammatory controls and inflammatory colitis of another cause)based on histopathological findings.Histopathology was reassessed in a subset of patients(28 DiC with atherosclerosis,DiC without atherosclerosis and ischaemic colitis each)for validation purposes.Medical history was collected from the electronic database and patient records.Statistical analysis included chi-squared test,t-test,logistic and multivariate regression models.RESULTS Drug-induced colitis was detected in 211 endoscopically sampled biopsy specimens of the colon mucosa(7%of all screened colonoscopic biopsy samples);a total of 633 patients were included equally matched throughout the three groups(291 males,mean age:62.1±16.1 years).In the univariate analysis,DiC was associated with diuretics,dihydropyridines,glycosides,ASS,platelet aggregation inhibitors,nonsteroidal anti-inflammatory drugs(NSAIDs),statins and fibrates,and with atherosclerosis,particularly coronary heart disease,and hyperlipoproteinaemia.Echocardiographic parameters did not show substantial differences.In the multivariate analysis only fibrates[odds ratio(OR)=9.1],NSAIDs(OR=6.7)and atherosclerosis(OR=2.1)proved to be associated with DiC.Both DiC reassessment groups presented milder inflammation than ischaemic colitis.The DiC patients with atherosclerosis exhibited histological features from both DiC without atherosclerosis and ischaemic colitis.CONCLUSION Several drugs indicated for the treatment of cardiovascular and related diseases are associated with DiC.Atherosclerosis and microcirculatory disturbances seem to play an important pathogenetic role. | Thorsten Brechmann Katharina Günther Matthias Neid Wolff Schmiegel Andrea Tannapfel | 2019 | World Journal of Gastroenterology2019，25，8： | 3 |
| 2 | Particulate elemental carbon in the atmosphere 显示文摘 | Wolff G T | 1981 | Journal of the Air Pollution Control Association1981，31，： | 1 |
| 3 | Structure of renal organic anion and cation transporters 显示文摘 | Burckhardt G Wolff N A | 2000 | Am J Physiol Renal Physiol2000，278，6： | 1 |
| 4 | Does biodiversity of estuarine phytoplankton depend on hydrology显示文摘 | FERREIRA J G WOLFF W J SIMAS T C | 2005 | Ecological Modelling2005，187，4： | 1 |
| 5 | Stress determination by hydraulic fracturing subsurface waste injection显示文摘 | Wolff R G Bredehoeft J D Keys W S | | 0，，09： | 1 |
| 6 | Impact of clinically silent inflammation on male genital tract organs as reflected by biochemical markers in semen显示文摘 | Bezold G Zebhauser M | 1991 | J Androl1991，12，5： | 1 |
| 7 | Relationship between Horizontal Strainnear a Well and Reverse Water Level Fluctuation显示文摘 | Wolff R G | 1970 | Water Resour Res1970，6，6： | 1 |
| 8 | Pilot study of urinary biomarkers of phytoestrogens,phthalates,and phenols in girls显示文摘 | Wolff M S Teitelbaum S L Windham G | 2007 | Environmental Health Perspectives2007，，： | 1 |
| 9 | Blood levels of organochlorine residues and risk of breast cancer显示文摘 | Wolff M S Toniolo P G Lee E W | 1994 | J Natl Cancer Inst1994，86，21： | 1 |
| 10 | Prevalence, expenditures, and complications of multiple chronic conditions in the elderly 显示文摘 | Wolff JL Starfield B Anderson G | 2002 | Arch Intern Med2002，162，20： | 1 |
| 11 | Acute haemorrhagic encephalomyelitis(AHEM):MRI findings显示文摘 | Mader I Wolff M Niemann G | 2004 | Neuropediatrics2004，35，2： | 1 |
| 12 | The chaotic oscillations of a josephson junction with external magnetic field 显示文摘 | Ma J G Wolff I | 1996 | IEEE Trans Magn1996，32，3： | 1 |
| 13 | Adaptive response of human lymphocytes to low concentration of radioactive thymidine 显示文摘 | OLIVIERI G WOLFF S | 1984 | Science1984，223，4636： | 1 |
| 14 | Spontaneous retroperitoneal haemorrhage associated renal disease显示文摘 | Jung PK Adam G | 1998 | J R Coll Surg Edinb1998，43，1： | 1 |
| 15 | Met5-enkephalin protects isolated adult rabbit cardiomyocytes via delta-opioid receptor显示文摘 | TAKASAKI Y WOLFF R A CHIEN G L | 1999 | Am J Physiol1999，277，62： | 1 |
| 16 | Arsenic neurotoxicity : a review 显示文摘 | Vahidnia A van der Voet G B de Wolff F A | 2007 | Human & Experimental Toxicology2007，26，10： | 1 |
| 17 | The coefficient of haze as a measure of particulate elemental carbon显示文摘 | Wolff G T Stroup C M Stroup D P | 1983 | Air Pollu Control Associ1983，33，8： | 1 |
| 18 | High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA显示文摘 | Zhang G Budker V Wolff JA | 1999 | Hum Gene Ther1999，10，10： | 1 |
| 19 | Ranolazine stimulates glucose oxidation in normoxic ischemic and reperfusion ischemicrat hearts显示文摘 | MCCORMACK J G BARR R L WOLFF A A | 1996 | Circulation1996，93，1： | 1 |
| 20 | Adaptive response of human lymphocytes to low concentrations of radioactive thymidine显示文摘 | OLIVIERI G BODYCOTE J WOLFF S | 1984 | Science1984，223，4636： | 1 |
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