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| 1 | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study显示文摘AIM To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.METHODS We used data from PsyC oL aus, a large Swiss Population Cohort Study(n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety(early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders(men), and measles/mumps/rubella-infections with early and late anxiety disorders(women). Gastric inflammatory diseases took effect in mood disorders(both sexes) and in early disorders(men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne(associations with mood disorders in men) and psoriasis(associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders(men), and neurodevelopmental and early anxiety disorders(women).CONCLUSION Infectious, atopic and inflammatory diseases areimportant risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. | Vladeta Ajdacic-Gross Aleksandra Aleksandrowicz Stephanie Rodgers Margot Mutsch Anja Tesic Mario Müller Wolfram Kawohl Wulf R?ssler Erich Seifritz Enrique Castelao Marie-Pierre F Strippoli Caroline Vandeleur Roland von K?nel Rosa Paolicelli Markus A Landolt Cornelia Witthauer Roselind Lieb Martin Preisig | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 2 | Hitting the Memory Wall: Implications of the Obvious显示文摘 | Wulf W A McKee S A | 1995 | Computer Architecture News1995，23，1： | 1 |
| 3 | The use of polymers with enzyme-analogus structures for the resolution of racemates显示文摘 | Wulf G Sarhan A | 1973 | Tetrahedron Lett1973，，： | 1 |
| 4 | PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells显示文摘 | Ryo A Liou Y C Wulf G | 2002 | Mol Cell Biol2002，22，15： | 1 |
| 5 | Fluorescent phallotoxin, a tool for the visualization of cellular actin显示文摘 | Wulf E Deboben A Bautz FA | 1979 | Proc Natl Acad Sci U S A1979，76，9： | 1 |
| 6 | Enhancing the learning of sport skills through external-focus feedback 显示文摘 | Wulf G McConnel N G? rtner M Schwarz A | 2002 | J Motor Behavior2002，34，： | 1 |
| 7 | The legion vision of a worldwide virtual computer显示文摘 | Grimshaw A S Wulf W A | 1997 | Communications of the ACM1997，40，1： | 1 |
| 8 | Pinl regulates turnover and suhcellular localization of beta-catenin by inhibiting its interaction with APC 显示文摘 | Ryo A Nakamura N Wulf G | 2001 | Nat Cell Biol2001，3，： | 1 |
| 9 | Reducing knowledge of results about relative versus absolute timing: Differential effects on learning显示文摘 | Wulf G Lee T D Schmidt R A | 1994 | Journal of Motor Behavior1994，，26： | 1 |
| 10 | Sunless skin tanning with dihydroxyacetone delays broad-spectrum ultraviolet photocarcinogenesis in hairless mice显示文摘 | Peteren A B Renhua Na Wulf H C | 2003 | Multation Research2003，542，12： | 1 |
| 11 | A distinct side population of cells with high drug efflux capacity in human tumor cells显示文摘 | Hirschmann-Jax C Foster A E Wulf G G | 2004 | Proc Natl Acad Sci USA2004，101，14： | 1 |
| 12 | Role of Pin1 in the regulation of p53 stability and p21 transactivation,and cell cycle checkpoints in response to DNA damage 显示文摘 | WULF G M LIOU Y C RYO A | 2002 | J Biol Chem2002，277，47： | 1 |
| 13 | Pinl is an E2F target gene essential for the Neu/Ras-induced transformation of mammary epithelial cells 显示文摘 | Ryo A Liou YC Wulf G | 2002 | Mol Cell Biol2002，22，： | 1 |
| 14 | Sunless skin tanning with dihydroxyacetone delays broad-spectrum ultraviolet Photocarcinogenesis in hairless mice显示文摘 | Petersen A B Na R Wulf H C | | 0，，1： | 1 |
| 15 | A distinct 'side population' of cells in human tumor cells: implications for tumor biology and therapy 显示文摘 | Hirschmann-Jax C Foster A E Wulf G G | 2005 | Cell Cycle2005，4，2： | 1 |
| 16 | Effects of high-protein/low-carbohydrate swine diets during the final finishing phase on pork muscle quality显示文摘 | Leheska J M Wulf D M Clapper J A Thaler R C Maddock R J | 2002 | Journal of Animal Science2002，80，1： | 1 |
| 17 | Hitting the memory wall impli- cations of the obvious显示文摘 | Wulf W A Mckee S A | 1995 | Computer Architecture News1995，23，1： | 1 |
| 18 | Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of C-Jun towards eyelin D1显示文摘 | Wulf GM Ryo A Wulf GG | 2001 | EMBO J2001，20，： | 1 |
| 19 | Role of Pinl in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage 显示文摘 | Wulf GM Liou YC Ryo A | 2002 | J Biol Chem2002，277，47： | 1 |
| 20 | A distinct 'side population' of cells with high drug efflux capacity in human tumor cells显示文摘 | Hirschmann-Jax C Foster A E Wulf G G | 2004 | Proc Natl Aead Sci USA2004，101，39： | 1 |
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