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| 1 | High concentrations of human β-defensin 2 in gastric juice of patients with Helicobacter pylori infection显示文摘AIM: Human β-defensin (HBD)-1 and HBD-2 are endogenous antimicrobial peptides. Unlike HBD-1, the HBD-2 expression is augmented by Helicobacter pylori (H pylori). We sought to determine HBD-1 and HBD-2 concentrations in gastric juice duringH pylori infection.METHODS: HBD-1 and HBD-2 concentrations were measured by radioimmunoassay in plasma and gastric juice of 49 H pylori-infected and 33 uninfected subjects and before and after anti-H pyloritreatment in 13 patients with H pylori-associated gastritis. Interleukin (IL)-1β and IL-8 concentrations in gastric juice were measured by enzyme-linked immunosorbent assay (ELISA). Histological grades of gastritis were determined using two biopsy specimens taken from the antrum and corpus. Reverse phase high performance liquid chromatography (RP-HPLC)was used to identify HBD-2.RESULTS: HBD-2 concentrations in gastric juice, but not in plasma, were significantly higher in H pylori-positive than -negative subjects, albeit the post-treatment levels were unchanged. Immunoreactivity for HBD-2 was exclusively identified in H pylori-infected mucosa by RPHPLC. HBD-2 concentrations in gastric juice correlated with histological degree of neutrophil and mononuclear cell infiltration in the corpus. IL-1β levels correlated with those of IL-8, but not HBD-2. Plasma and gastric juice HBD-1concentrations were similar in H pylori-infected and uninfected subjects.CONCLUSION: Our results place the β-defensins, especially HBD-2, in the front line of innate immune defence.Moreover, HBD-2 may be involved in the pathogenesis of H pylori-associated gastritis, possibly through its function as immune and inflammatory mediator. | Hajime Isomoto Hiroshi Mukae Hiroshi Ishimoto Yoshito Nishi Chun-Yang Wen Akihiro Wad Ken Ohnita Toshiya Hirayama Masamitsu Nakazato Shigeru Kohno | 2005 | World Journal of Gastroenterology2005，11，31： | 10 |
| 2 | Ebulliometric study of thedecomposition of urea in aqueous media 显示文摘 | Azevedo F G D Oliveira WAD | 1984 | InternationalJournal of Chemical Kinetics1984，16，7： | 1 |
| 3 | Isothermal microcalorimetry in applied biology 显示文摘 | Wads? I | 2002 | Thermochim Acta2002，394，： | 1 |
| 4 | Autologous mesenchymal stem cell-mediated repari of tendon 显示文摘 | Wad HA Butler DL Boivin GP | 1999 | Tissue Eng1999，5，3： | 1 |
| 5 | Simultaneous determination of eleven antiepileptic compounds in serum by high-performance liquid chromatography显示文摘 | WAD N | 1984 | J Chromatogr1984，305，1： | 1 |
| 6 | macrophage migration inhibitory factor in the human ovary:presence in the follicular fluids and production by granulose cells显示文摘 | Wads S Fujimoto S Mizue Y | 1997 | Biuchem Mol Billnt1997，41，4： | 1 |
| 7 | Ischemia - reperfusion decreases protein phosphorylation and p38 mitogen - activated protein kinase phosphorylation in rat lung transplants 显示文摘 | Sakiyama S dePerrot M Hart B Wadded TK Keshavjee S Liu M | 2003 | J Heart Lung Transplantation2003，22，： | 1 |
| 8 | Pathophysiologieal response to hy-poxia - from the molecular mechanisms of malady to drug discovery: epigenetic regulation of the hypoxic response via hypoxia - inducible factor and histone modifying enzymes 显示文摘 | Mimura I Tanaka T Wads Y | 2011 | J Pharmacol Sci2011，115，4： | 1 |
| 9 | BLastocystis hominis as acause of hypoalbuminemia and anasarca显示文摘 | Nassir E A wad J Abel AB | 2004 | Eur J Clin MicrobiolInefect Dis2004，23，5： | 1 |
| 10 | Pathophysiological re- sponse to hypoxia-from the molecular mechanisms of mala- dy to drug discovery: epigenetic regulation of the hypoxic response via hypoxia-inducible factor and histone modifying enzymes显示文摘 | Mimura I Tanaka T Wads Y | 2011 | J Pharmacol Sci2011，115，4： | 1 |
| 11 | Insightsantifibrotic mechanism of methyl palmitate: impact on nuclearfactor kappa B and proinflammatory cytokines 显示文摘 | Mantawy EM Tadros MG A wad AS | 2012 | ToxicolAppl Pharmacol2012，258，1： | 1 |
| 12 | Isothermal Microcalorimetry in Applied Biology显示文摘 | Wads I | 2002 | Thermochimica Acta2002，394，： | 1 |
| 13 | Expression of pigment epithelium- derived factor in normal adult rat eye and experimental choroidal neovascularization显示文摘 | Ogata N Wads M Otsuji T | 2002 | Invest Ophthalmol Visual Science2002，43，4： | 1 |
| 14 | Subjective response to neurolepties and quality of life-implications for treatment outcome显示文摘 | A wad AG | 1994 | Acta Psychiatrica Scandinarica1994，89，380： | 1 |
| 15 | Guidelines for acute coronary syndrom without ST elevation显示文摘 | Wad DJ Taylor R | 2002 | Lancet2002，359，： | 1 |
| 16 | Physical activity and diabetes complications in patients with type l diabetes:the Finnish Diabetic Nephropathy (FinnDiane) Study显示文摘 | Wadén J Forsblom C Thorn LM | | 0，，02： | 1 |
| 17 | The relationship between impairedglucose tolerance,type 2 diabetes,and cognitive function显示文摘 | A wad N Gagnon M Messier C | 2004 | ClinExp Neuropsychol2004，26，8： | 1 |
| 18 | The Development of Automotive Parts Suppliers in Korea and Malaysia: A Global Value Chain Perspective 显示文摘 | Peter WAD | 2008 | Asia Pacific Business Review2008，，14： | 1 |
| 19 | Histone deacetylases are critical targets of bortezomib-indueed cytotoxicity in multiple myelo- ma显示文摘 | Kikuchi J Wads T Shimizu R | 2010 | Blood2010，116，3： | 1 |
| 20 | Induction of transforming growth factor-betal by basic fibroblast growth factor in rat C6 glioma cells and astrocytes is mediated by MEK/ERK signaling and AP-1 activation显示文摘 | Dhandapani K M Khan M M Wad F M | 2007 | J Neurosci Res2007，85，5： | 1 |
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