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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Synthesis of oligonucleotide funetionalized magnetic nanoparticles and study on their in vitro cell uptake显示文摘 | Wagner K Kautz A Roder M | 2004 | Appl Organometal Chem2004，18，： | 1 |
| 3 | Induction of cellular genes is mediated by the Bell transactivator in foamy virus-infected human cells显示文摘 | Wagner A Doerks A Aboud M | 2000 | J Virol2000，74，： | 1 |
| 4 | Electrophoretic, solubility, and functional properties of commercial soy protein isolartes 显示文摘 | Arrese E L Sorgentini D A Wagner J R Anon M C | 1991 | Journal of Agricultural and Food Chemistry1991，39，： | 1 |
| 5 | Develop- ment of a multiplex and semi-nested PCR assay for detection of Yersinia enterocolitica and Aeromonas hydrophila in rawmilk显示文摘 | YESIM Z O LEHNER A WAGNER M | 2000 | Food Microbiol2000，17，： | 1 |
| 6 | Liver surgery in the era of tissue-preserving resections:early and late outcome in patients with primary and secondary hepatic tumors显示文摘 | Redaelli C A Wagner M Krahenbuhi L | 2002 | World J Surg2002，26，9： | 1 |
| 7 | Thermal and electrophoretic behavior,hydrophobicity,and some functional properties of acid-treated soy isolates显示文摘 | Wagner J R Sorgentini D A Anon M C | 1996 | J Agri Food Chem1996，44，： | 1 |
| 8 | 显示文摘 | Nelson J A Brant E L Wagner M J | 2003 | Chem Mater2003，15，： | 1 |
| 9 | Placental site trophoblastic tumor: human placental lactogen and preg- nancy-associated major basic protein as immunohistologic markers 显示文摘 | Rhoton-Vlasak A Wagner J M Rutgers J L | 1998 | numPalhol1998，29，3： | 1 |
| 10 | 3' -fluoro-3' -deoxythymidine (- FLT) as positron emission tomography in a murine B-cell lymphoma model and in the human disease显示文摘 | Wagner M Seitz U Buck A | 2003 | Cancer Res2003，63，10： | 1 |
| 11 | Recovery of hypopituitarism after neurosurgical treatment of pituitary adenomas 显示文摘 | Webb SM Rigla M Wagner A | 1999 | J Clin En- docrinol Metab1999，84，10： | 1 |
| 12 | Characterization of activated sludge floes by confooal laser scanning microscopy and image analysis显示文摘 | Schmid M Thill A Purkhold U Walcher M Bottero J Y Ginestet P Nielsen P H Wuertz S Wagner M | | 0，，09： | 1 |
| 13 | Single-port cholecystectomy versus multi-port cholecystectomy:a prospective cohort study with 222 patients显示文摘 | Wagner M J KemH Hapfelmeier A | 2013 | WorldJSurg2013，37，5： | 1 |
| 14 | Chloroplast DNA polymorphisms in lodgepole and jack pines and their hybrids 显示文摘 | Wagner D B Furnier G R Saghai-Maroof M A | 1987 | Proc Natl Acad Sci USA1987，84，： | 1 |
| 15 | 显示文摘 | WAGNER D D M | 1999 | Can J Chem1999，77，： | 1 |
| 16 | Phylogeny of dissimilatory sulfite reduetases supports an early origin of sulfate respiration 显示文摘 | Wagner M Roger A J Flax J L | 1998 | Journal of Bacteriology1998，180，11： | 1 |
| 17 | Novel real -time PCR assay for simultaneous detection anddifferentiation of Clostridium chauvoei and Clostridium septicum in clostridial myonecrosis显示文摘 | Halm A Wagner M Kofer J | 2010 | J ClinMicrobiol2010，48，4： | 1 |
| 18 | Community Structure and activity dynamics of nitrifying bacteria in a phosphate-removing biofilm显示文摘 | Gieseke A Purkhold U Wagner M | 2001 | Applied and Environmental Microbiology2001，67，3： | 1 |
| 19 | Determinants of persist- ence in canine distemper voruses显示文摘 | Stettler M Beck K Wagner A | 1997 | Vet Microbiol1997，57，1： | 1 |
| 20 | Evaluation of texture features in spatial domain for automatic discrimination of histologic tissue显示文摘 | WILTGEN M GERGER A WAGNER C | 2007 | Anal Quant Cytol Histo12007，29，4： | 1 |
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