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| 1 | Engineering death receptor ligands for cancer therapy显示文摘 | WAJANT H | 2010 | Cancer Lett2010，12，： | 5 |
| 2 | TNF related apoptosis in ducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy显示文摘 | Wajant H Pfizenmaier K Scheurich P | 2002 | Apoptosis2002，7，5： | 1 |
| 3 | The Fas signaling pathway:more than a paradigm 显示文摘 | Wajant H | 2002 | Science2002，296，5573： | 1 |
| 4 | The TNF-tumor necrosis factor family: Scaffold molecules for cytokine receptors kinases and their regulators显示文摘 | Wajant H Henkler F Scheurich P | 2001 | Cell Signal2001，13，2： | 1 |
| 5 | The Fas signaling pathway: more than a paradigm显示文摘 | Wajant H | 2002 | Science2002，296，5573： | 1 |
| 6 | Tumor necrosis factor (TNF) receptor type 2 mediates thymocyte proliferation inde pendently of TNF receptor type 1显示文摘 | Grell M Becke FM Wajant H | 1998 | European Journal of Immu nology1998，28，1： | 1 |
| 7 | The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor显示文摘 | Grell M Douni E Wajant H | 1995 | Cell1995，83，5： | 1 |
| 8 | Stimulation of TNF receptor type 2 expands regulatory T cells and ameliorates established collagen-induced arthritis in mice显示文摘Tumor necrosis factor(TNF)and its receptors TNF receptor type 1(TNFR1)and type 2(TNFR2)have a central role in chronic inflammatory diseases.While TNFR1 mainly confers inflammation,activation of TNFR2 elicits not only pro-inflammatory but also anti-inflammatory effects.In this study,we wanted to investigate the anti-inflammatory therapeutic potential of selective activation of TNFR2 in mice with established collageninduced arthritis.Mice with established arthritis induced by immunization with bovine collagen type II were treated with six injections of the TNFR2-specific agonist TNCscTNF80,given every second day.Two days after treatment cessation,the cell compositions of bone marrow,spleen and lymph nodes were analyzed.Mice were visually scored until day 30 after the start of therapy and the degree of joint inflammation was determined by histology.Treatment with TNCscTNF80 increased arthritis-induced myelopoiesis.Little effect was seen on the infiltration rate of inflammatory immature myeloid cells and on the reduction of lymphoid cells in secondary lymphoid organs.Upon treatment,frequency of regulatory T(Treg)cells in the CD4+T-cell population was increased in both spleen and inguinal lymph nodes.In addition,the expression of TNFR2 on Treg cells was enhanced.The clinical score started to improve 1 week after cessation treatment and remained lower 30 days after initiation of therapy.The histological score also revealed amelioration of joint inflammation in TNCscTNF80-treated versus control mice.Activation of TNFR2 might provide a suitable therapeutic strategy in autoimmune arthritis by increasing the numbers of regulatory cell types,in particular Treg cells,and by attenuation of arthritis. | Vanessa Lamontain Tobias Schmid Dorothea Weber-Steffens David Zeller Zsuzsa Jenei-Lanzl Harald Wajant Rainer H Straub Daniela N Männel | 2019 | Cellular & Molecular Immunology2019，16，1： | 1 |
| 9 | TNFRl-induced activation of the classical NF-κB pathway显示文摘 | Wajant H Scheurich P | 2011 | FEBS J2011，278，6： | 1 |
| 10 | Death ligands designed to kill: development and application of targeted cancer therapeutics based on pro apoptotic TNF family ligands显示文摘 | GERSPACH J WAJANT H PFIZENMAIER K | 2009 | Results Probl Cell Differ2009，49，： | 1 |
| 11 | The Fas signaling pathway: more than a paradigm显示文摘 | Wajant H | 2002 | Science2002，296，5537： | 1 |
| 12 | The TWEAK - Fnl4 system as a potential drug target 显示文摘 | Wajant H | 2013 | Br J Pharmacol2013，170，4： | 1 |
| 13 | Therapeutic targeting of CD95 and the TRAIL death receptors显示文摘 | Gerspach J Pfizenmaier K Wajant H | 2011 | Recent Pat Anticancer Drug Discov2011，6，3： | 1 |
| 14 | Implication of TNF-Related Apoptosis Inducing Ligand in Inflammatory Intestinal Epithelial Lesions 显示文摘 | Begue B Wajant H Bambou JC | 2006 | Gastroenterology2006，130，7： | 1 |
| 15 | TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy显示文摘 | Wajant H Pfizenmaier K Scheurich P | 2002 | Apoptosis2002，7，5： | 1 |
| 16 | TRAIL and NF kappa B signaling-a complex relation- ship显示文摘 | Wajant H | 2004 | Vitam Horm2004，67，： | 1 |
| 17 | The Fas signaling pathway: more than a paradigm显示文摘 | Wajant H | 2002 | Science2002，296，5573： | 1 |
| 18 | TNF receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1显示文摘 | Grell M Becke FM Wajant H Mannel DN Scheurich P | 1998 | Eur J Immunol1998，28，： | 1 |
| 19 | 显示文摘 | Wajant H | 2002 | Science2002，296，32： | 1 |
| 20 | The TNF-receptor-associa:ted factor family: scaffold molecules for cytokine receptors, ki nases and their regulators显示文摘 | Wajant H Henkler F Scheurich P | 2001 | Cell Signal2001，13，6： | 1 |
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