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| 1 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 2 | 健康领域的文化能力显示文摘1背景
尽管人类对其他社会的兴趣纵贯历史的各个阶段,但是检验不同文化概念对人类健康实践的影响从20世纪才开始,当时是伴随着长期的人类学田野调查产生的,这些田野调查揭露了不同文化之间相关卫生实践的多样性、复杂性和连续性。 | Napier A D Ancarno C Butler B Calabrese j Chater A Chatterjee H Guesnet F Home R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams AC Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，2： | 5 |
| 3 | 围孕期补充叶酸和/或多种维生素预防神经管缺陷显示文摘1背景
神经管缺陷(NTDs)是在脑和脊索发育过程中形成的先天性畸形,包括无脑儿(颅骨、表面皮肤和脑组织全部或部分缺失)、脊柱裂(脊柱未闭合造成的脊索、脊膜分别或同时突出或暴露;有些病例合并脑积水)和脑膨出(脑膜疝,脑组织位于颅骨外,表面被正常或萎缩皮肤覆盖). | Lumnley J Watson L Watson M Bower C 陈晓军 丰有吉 | 2005 | 生殖与避孕2005，25，7： | 3 |
| 4 | 文化、不平等性与卫生服务提供显示文摘1动态不平等性对基层医疗卫生人力的影响
政治、社会、文化、专业群体皆建立在一致且常规的人类行为之上。当遭受巨大变革和内外压力时,这些群体会变得十分脆弱。尤其在动荡时期,这些群体往往更关注社会和文化的差异性,而非二者的一致性。尽管社会中的个体思维和行为会呈现较大的差异,但对健康的感知具有统一性,并在更广范围人群内尤为突出,这主要归因于文化价值观的作用。广义的文化心态会随着时间和地理位置的不同而不同,就像健康的社会决定因素也会因文化类型的不同而产生差异。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，3： | 2 |
| 5 | Maturity indices for composted dairy and pig manures显示文摘 | P Wang C M Changa M E Watson | 2004 | Soil Biology and Biochemistry2004，36，： | 1 |
| 6 | 医疗卫生保健文化的反思及促进健康与文化融合的建议显示文摘1医疗卫生保健文化的反思1.1健康文化与医学知识如果医务人员有充足的时间对患者进行诊断并帮助患者进行社区护理,就可在节省卫生费用的同时改善健康结果。整合型社区护理能缩小不同文化背景和群体健康需求的差异。然而,全球范围内对整合型社区护理的投入较少,原因之一就是20世纪对临床服务的重视弱化了卫生服务提供过程中的同情心理。当然,患者也对医学知识存在显性和隐性的影响(特别是当其因不遵医嘱而受到指责时)。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson JWoolf K | 2016 | 中国卫生政策研究2016，9，4： | 1 |
| 7 | Root strength, growth, and rates of decay: root reinforcement changes of two tree species and their contribution to slope stability显示文摘 | Watson A Phillips C Marden M | 1999 | Plant and Soil1999，217，： | 1 |
| 8 | Analysis of the phases developed by laser uitriding Ti-6Al-4V alloys显示文摘 | Xin H Watson L M | 1997 | Acta Materialia1997，，45： | 1 |
| 9 | Identification of polymorphisms within the vascular endothelial growth factor (VEGF) gene: correlation with variation in VEGF protein production显示文摘 | WATSON C J WEBB N J BOTTOMLEY M J | 2000 | Cytokine2000，12，： | 1 |
| 10 | Short-and long-term hospital and community exercise programmes for patients with chronic obstructive pulmonary disease显示文摘 | Elliott M Watson C Wilkinson E | 2004 | Respirology2004，9，3： | 1 |
| 11 | Model Predictive Control of a Fuel Injection System with a Radial Basis Fucntion Network Observer显示文摘 | Manzie C Palaniswami M Watson H | 2002 | ASME Journal of Dynamic Systems Measurement and Control2002，124，4： | 1 |
| 12 | Varicella disease after introduction of varicella vaccine in the United States,1995-2000显示文摘 | SEWARD J F WATSON B M PETERSON C L | 2002 | JAMA2002，287，5： | 1 |
| 13 | Bregma, lambda and the interaural midpoint in stereotaxic surgery with rats of different sex, strain and weight 显示文摘 | Paxinos G Watson C Pennisi M Topple A | 1985 | Journal of neuroscience methods1985，13，： | 1 |
| 14 | A CDK-independent function of mammalian cks1 :targeting of SCF molecular cell inhibitor P27显示文摘 | Spruck C Stohmaier H Watson M | 2001 | Mol Cell2001，7，3： | 1 |
| 15 | lnteraction of DNAbinding proteins with a milk protein gene promoter in vitro: identification of a mammary gland-specific factor 显示文摘 | Watson C J Gordon K E Robertson M | 1991 | Nucleotide Acids Res1991，19，23： | 1 |
| 16 | Clenbuterol,a beta-adrenoceptor agonist, incerases relative muscle strength in orthopacdic patients显示文摘 | Maltin C A Delday M I Watson J S | 1993 | Clinical Science (Colch)1993，84，3： | 1 |
| 17 | Review of volatile organic compound source apportionment by chemical mass balance显示文摘 | WATSON J G CHOW J C FUJITA E M | 2001 | Atmospheric Environment2001，35，： | 1 |
| 18 | The electronic structure of oxygen vacancy defects at the low index surfaces of ceria显示文摘 | Nolan M Parker S C Watson G W | 2005 | Surf Sci2005，595，： | 1 |
| 19 | Genotyping and phenotyping of platelet function disorders显示文摘 | Watson S P Lowe G C Lordkipanidze M | 2013 | J Thromb Haemost2013，11，1： | 1 |
| 20 | Low-Energy Membrane Nanofihration for Removal of Color, Organics and Hardness From Drinking Water Supplies显示文摘 | Watson B M Hornhurt C D | 1994 | Chemical Engineering Progress1994，3，： | 1 |
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