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| 1 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 2 | 麻风无痛性神经炎——康复试点报告显示文摘对八个康复试点的3571例病人定期进行神经功能检查,发现无痛性神经炎151例(4.2%),共累及330条神经,包括面神经15条,尺神经98条,正中神经36条,胫后神经148条及腓总神经33条。经强的松标准方案治疗,神经功能好转235条(71.2%),其中恢复优、良者196条(59.4%),表明强的松治疗麻风无痛性神经炎既简单又行之有效,可作为常规,以减少神经不可逆性损害。讨论了无痛性神经炎与MDT的关系及其感觉与运动功能的恢复。 | 蒋娟 张国成 韦晓宇 严良斌 李文忠 郑逖生 Jakeman P Watson J Smith C Goh Siam Kiang | 1996 | 中国麻风杂志1996，12，3： | 5 |
| 3 | Maturity indices for composted dairy and pig manures显示文摘 | P Wang C M Changa M E Watson | 2004 | Soil Biology and Biochemistry2004，36，： | 1 |
| 4 | Prognostic significance of a novel hypoxia-regulated marker,carbonic anhydrase IX,in invasive breast carcinoma显示文摘 | Chia S K Wykoff C C Watson P H | 2001 | J Clin Oncol2001，19，16： | 1 |
| 5 | Air-sea gas exchange in rough and stormy seas measured by a dual-tracer technique显示文摘 | Watson A J Upstill Goddard C R Liss P S | 1991 | Nature1991，349，14： | 1 |
| 6 | Angioedema as a hypersensitivity reaction to polyethylene glycol oral electrolyte solution显示文摘 | Assal C Watson P Y | 2006 | Gastrointest Endosc2006，64，2： | 1 |
| 7 | Identifying a randomly amplified polymorphic DNA(RAPD)marker linked to a gene for root-knot nematode resistance in sweetpotato显示文摘 | Ukoskit K Thompson P G Watson Jr C E | 1997 | J Am Soc Hort Sci1997，122，： | 1 |
| 8 | Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonanee imaging显示文摘 | Watson C Andermann F Gloor P | 1992 | Neurology1992，42，9： | 1 |
| 9 | new hybrid algorithm for analysis of HVDC and FACTS systems显示文摘 | Anderson G W J Watson N R Arnold C P | 1995 | Proceedings of the International Conference on Energy Management and Power Delivery1995，2，： | 1 |
| 10 | Partial melting ofamphibolite/ eclogite and the origin of Archean trondhjemites and tomalities显示文摘 | Rapp R P Watson E B Miller C F | 1991 | Precambrian Research1991，51，： | 1 |
| 11 | Impact of solid Earth tide models on GPS coordinate and tropospheric time series显示文摘 | Watson C Tregoning P Coleman R | | 0，，08： | 1 |
| 12 | AChE-stained horizontal sections of the rat brain in stereotaxic coordinates 显示文摘 | Paxinos G Watson C R Emson P C | 1980 | J Neurosci Methods1980，3，12： | 1 |
| 13 | Genotyping and phenotyping of platelet function disorders显示文摘 | Watson S P Lowe G C Lordkipanidze M | 2013 | J Thromb Haemost2013，11，1： | 1 |
| 14 | Identifying a randomly amplified polymorphie DNA (RAPD) marker linked to a gene form root-knot nematode resistance in sweetpotato 显示文摘 | UKOSKIT K THOMPSON P G WATSON J R C E | 1997 | J of the Amer Soei Hort Sci1997，122，6： | 1 |
| 15 | Identifia- ble factors in post-prostatectomy haemorrhage: the role of aspirin显示文摘 | Watson C J Deane A M Doyle P T | 1990 | BrJ Urol1990，66，： | 1 |
| 16 | A mesoscale phytoplankton boom in the polar southern ocean stimulated by iron fertilization 显示文摘 | Boyd P W Watson A J Law C S etal | 2000 | Nature2000，407，： | 1 |
| 17 | Maturity indices for composted dairy and pig manures 显示文摘 | P Wang C M Changa M E Watson | 2004 | Soil Biology and Biochemistry2004，36，： | 1 |
| 18 | Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging显示文摘 | Andermann F Gloor P | 1992 | Neurology1992，42，9： | 1 |
| 19 | Interfacial modification of polypropylene composites filled with magnesium hydroxide显示文摘 | Hornsby P R Watson C L | 1995 | Journal of Materials Science1995，30，： | 1 |
| 20 | Electrolytic preparation of periodate oxystarch 显示文摘 | Mehltretter C L Rankin J C Watson R P | 1957 | Industrial and Engineering Chem1957，49，： | 1 |
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