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| 1 | Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies显示文摘在地岬基因的 Oncogenic 变化在人的癌症是很普通的,导致有描绘得好的选择优点,而且不太听说得好的危险的房间。我们执行了一幅大规模 loss-of-function 屏幕识别被转变 KRAS 的结肠癌房间,然而并非由缺乏这 oncogene 的衍生物要求的基因。最高得分的基因然后在 KRAS 变异、野类型的癌症房间的一块更大的面板被测试。表示 oncogenic KRAS 的癌症房间被发现高度依赖于抄写因素 GATA2 和 DNA 复制开始管理者 CDC6。与已知的目标用许多药扩大这分析,我们发现有变异的 KRAS 的癌症房间与 topoisomerase 抑制显示出选择嗜好到 proteasome 功能,以及合成致命性。联合指向引起的这些功能改善了相对野类型的房间 KRAS 变异的房间杀死。这些观察建议新奇目标和在地岬变异的癌症为最佳的效果联合存在治疗的新方法,它传统地被看作对治疗高度倔强。 | Michael Steckel Miriam Molina-Arcas Britta Weigelt Michaela Marani Patricia H Warne Hanna Kuznetsov Gavin Kelly Becky Saunders Michael Howell Julian Downward David C Hancock | 2012 | Cell Research2012，22，8： | 5 |
| 2 | Linezolid reduces length of stay and duration of intravenous treatment compared with vancomycin for complicated skin and soft tissue infections due to suspected or proven methicillin-resistant Staphylococcus aureus (MRSA)显示文摘 | Itani K M Weigelt J Li J Z | 2005 | lnt J Antimicrob Agents2005，26，6： | 1 |
| 3 | The novel acti- vated microgha/macrophage WAP domain protein, AMWAP, acts as a counter-regulator of proinflammatory response 显示文摘 | Karlstetter M Walczak Y Weigelt K | 2010 | J Immunol2010，185，6： | 1 |
| 4 | Metaplastic breast carci- nomas are basal-like breast cancers, a genomic profiling anal- ysis显示文摘 | Weigelt B Kreike B Reis-Filho JS | 2009 | Breast Cancer Res Treat2009，117，2： | 1 |
| 5 | Reputation and corporate strategy:A review of recent theory and applications 显示文摘 | Weigelt K Camerer C | 1998 | Strategic Management Journal1998，，9： | 1 |
| 6 | Indices of plant competition显示文摘 | Weigelt A Jolliffe P | 2003 | J Ecol2003，91，： | 1 |
| 7 | Metaplastic breast carcinoma:more than a special type显示文摘 | Weigelt B Eberle C Cowell CF | 2014 | Nat Rev Cancer2014，14，3： | 1 |
| 8 | The surgical management of duodenal trauma 显示文摘 | Snyder WH Weigelt JA Watkins WL | 1980 | Arch Surg1980，115，5： | 1 |
| 9 | Marker genes for circulating tumour cells predict survival in metastasized breast cancer patients显示文摘 | Weigelt B Bosma AJ Hart AA | 2003 | BrJ Cancer2003，88，7： | 1 |
| 10 | The structure of organizational incentives 显示文摘 | Lambert R Larcker D Weigelt K | 1993 | Administrative Science Quarterly1993，38，： | 1 |
| 11 | How sensitive is executive compensation to organization size显示文摘 | Lambert Richard A Larcker D F Weigelt K | 1991 | Strategic Management1991，12，： | 1 |
| 12 | Immune mediatorsin patients with acute diabetic foot syndrome 显示文摘 | Weigelt C Rose B Poschen U | 2009 | DiabetesCare2009，32，8： | 1 |
| 13 | Indices of plant competition 显示文摘 | WEIGELT A JOLLEFFE P | 2003 | Journal of Ecology2003，91，： | 1 |
| 14 | Involvement of DPP-IV catalytic residues in enzyme - saxagliptin complex formatio显示文摘 | Metzler W J Yanchunas J Weigelt C | 2008 | Protein Science2008，17，： | 1 |
| 15 | Learning from Supply-Side Agents:The Impact of Technology Solution Providers' Experiential Diversity on Clients' Innovation Adoption 显示文摘 | Weigelt C Sarka M | 2009 | Academy of Management Journal2009，52，1： | 1 |
| 16 | The contribution of gene expression profiling to breast cancer classification, prognos- tication and prediction: a retrospective of the last decade 显示文摘 | Weigelt B Baehner FL Reis JS | 2010 | J Pathology2010，220，2： | 1 |
| 17 | Immune mediatorsin patients with acute diabetic foot syndrome显示文摘 | Weigelt C Rose B Poschen U | 2009 | DiabetesCare2009，32，8： | 1 |
| 18 | Reputation and Corporate Strategy: A Review of Recent Theory and Applications显示文摘 | Weigelt K Camerer C | 1988 | Strategic Man- agement Journal1988，9，5： | 1 |
| 19 | Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer 显示文摘 | Garcia-Murillas I Sehiavon G Weigelt B | 2015 | Sci Transl Med2015，7，30： | 1 |
| 20 | Reputation and corporate strate-gy:A review of recent theories显示文摘 | Weigelt K and Camerer C | 1988 | Strategic Management Journal1988，9，5： | 1 |
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