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| 1 | Langerin在Langerhans细胞组织细胞增生症和非Langerhans细胞组织细胞性疾病中的表达显示文摘 | Lan S K Chu P G Weiss L M 黄文斌(摘译) | 2008 | 临床与实验病理学杂志2008，24，5： | 23 |
| 2 | Socio-cultural determinants of timely and delayed treatment of Buruli ulcer: implications for disease control显示文摘Introduction:Public health programmes recommend timely medical treatment for Buruli ulcer(BU)infection to prevent pre-ulcer conditions from progressing to ulcers,to minimise surgery,disabilities and the socio-economic impact of BU.Clarifying the role of socio-cultural determinants of timely medical treatment may assist in guiding public health programmes to improve treatment outcomes.This study clarified the role of socio-cultural determinants and health system factors affecting timely medical treatment for BU in an endemic area in Ghana.Methods:A semi-structured explanatory model interview based on the explanatory model interview catalogue(EMIC)was administered to 178 BU-affected persons.Based on research evidence,respondents were classified as timely treatment(use of medical treatment 3 months from awareness of disease)and delayed treatment(medical treatment 3 months after onset of disease and failure to use medical treatment).The outcome variable,timely treatment was analysed with cultural epidemiological variables for categories of distress,perceived causes of BU,outside-help and reasons for medical treatment in logistic regression models.The median time for the onset of symptoms to treatment was computed in days.Qualitative phenomenological analysis of respondents’narratives clarified the meaning,context and dynamic features of the relationship of explanatory variables with timely medical treatment.Results:The median time for initiating treatment was 25 days for pre-ulcers,and 204 days for ulcers.Income loss and use of herbalists showed significantly negative associations with timely treatment.Respondents’use of herbalists was often motivated by the desire for quick recovery in order to continue with work and because herbalists were relatives and easily accessible.However,drinking unclean water was significantly associated with timely treatment and access to health services encouraged timely treatment(OR 8.5,p=0.012).Findings show that health system factors of access are responsible for non-compliance to treatment regimes.Conclusions:Findings highlight the importance of an integrated approach to BU control and management considering the social and economic features that influence delayed treatment and factors that encourage timely medical treatment.This approach should consider periodic screening for early case-detection,collaboration with private practitioners and traditional healers,use of mobile services to improve access,adherence and treatment outcomes. | Mercy M Ackumey Margaret Gyapong Matilda Pappoe Cynthia Kwakye Maclean Mitchell G Weiss | 2012 | Infectious Diseases of Poverty2012，1，1： | 3 |
| 3 | 群体药物代谢动力学方法研究伏立康唑的变异度:以优化给药方案显示文摘伏立康唑为广谱抗真菌药物,主要经肝药代谢酶CYP2C19、或CYP3A4和CYP2C9代谢,其药动学特征呈非线性并变异程度大,且该药治疗窗窄,使临床应用复杂。本研究将4项健康受试者研究和2项患者临床研究的数据(包括240名受试者的3352个血药浓度数据)建立非线性混合效应模型分析(NONM EM ),以剂量模拟检验协变量影响效应和据CYP2C19表型分层的伏立康唑浓度(2~5 mg/L )达标情况。结果表明伏立康唑符合滞后时间的一级口服吸收和消除米氏方程的二房室模型。伏立康唑在健康受试者中的最大代谢速率(Vmax )比患者高111%。具有一个或多个CYP2C19功能缺失(LoF)等位基因的受试者的 Vmax较没有上述等位基因缺失的受试者偏低41.2%。合并使用苯妥英钠或利福平,圣约翰草提取物或糖皮质激素可显著增加伏立康唑的消除。口服或静脉注射伏立康唑200 mg ,每日2次,第7天的谷浓度<2 mg/L的概率对无CYP2C19 LoF等位基因的受试者分别为72%和63%;口服或静脉给药300 mg ,每日2次,该概率分别较低,为49%和35%。相反,对于具有CYP2C19 LoF等位基因的受试者,上述给药方案第7天的伏立康唑谷浓度>5 mg/L 的概率分别为29%、39%、57%和77%。因此,目前伏立康唑的给药方案在无CYP2C19 LoF等位基因的受试者中暴露量偏低,需增加给药剂量,但在CYP2C19活性降低的受试者中暴露量则偏高。尽管本研究中伏立康唑生物利用度较高(94%),但个体差异较大(36.7%),且不同研究的结果差异较大(63%~96%),改变给药途径时也需要进行药物浓度监测。本研究表明,为保证伏立康唑的有效性和安全性,需进行治疗药物浓度监测。 | Dolton M J Mikus G Weiss J 赵苗 | 2015 | 中国感染与化疗杂志2015，15，5： | 2 |
| 4 | The pathophysiology of lower tract sympotoms after braehytherapy for prostate cancer显示文摘 | Blaivas J G Weiss J P Jones M | 2006 | BJU Int2006，98，6： | 1 |
| 5 | Distributed intelligent energy management system for a single-phase high- frequency AC mierogrid 显示文摘 | CHAKRABORTY S WEISS M D SIMOES M G | 2007 | IEEE Trans on Industrial Electronics2007，54，1： | 1 |
| 6 | Suction- lift sludge removal and non - Newtonian flow behaviour in circular secondary clarifiers: Numerical modelling and measurements 显示文摘 | Weiss M P16sz B G Essemiani K | 2007 | Chemical Engineering Journal2007，132，1： | 1 |
| 7 | Productivity and Technical Efficiency in the Italian Industry显示文摘 | CUMMINS J D TURCHETTI G WEISS M A | 1996 | Working paper1996，，： | 1 |
| 8 | Sublethal endotoxemia promotes pulmonary cytokine-induced neutrophil chemoattractant expression and neutrophil recruitment but not over lung injury in neonatal rats显示文摘 | TILLEMA M S LORENZ K L WEISS M G | | 0，，04： | 1 |
| 9 | Differential expression of MUC1, MUC2, and MUC5AC in carcinomas of various sites: an immunohistochemical study 显示文摘 | Lau S K Weiss L M Chu P G | 2004 | Am J Clin Pathol2004，122，1： | 1 |
| 10 | Mining with rarity: a unifying framework 显示文摘 | WEISS G M | 2004 | SIGKDD Explorations2004，6，1： | 1 |
| 11 | Interpolation of operators with change of measures显示文摘 | STEIN E M WEISS G | 1958 | Tran Amer Math Soc1958，87，： | 1 |
| 12 | Accelerated mechanical fatigue testing and lifetime of interconnects in microelectronics 显示文摘 | KHATIBI G LEDERER M WEISS B | 2010 | Proc Eng2010，2，1： | 1 |
| 13 | Activity recognition using cell phone accelerometers 显示文摘 | Kwapisz J R Weiss G M Moore S A | 2011 | ACMSIGKDD Explora- tionNewsletter2011，12，2： | 1 |
| 14 | The Painlevé property for partial differential equations显示文摘 | Weiss J Tabor M Garnevale G | 1983 | J Math Phys1983，24，3： | 1 |
| 15 | Using electrophoretic exclusion to manipulate small molecules and particles on a mierodevice 显示文摘 | Kenyon S M Weiss N G Hayes M A | 2012 | Eleetrophoresis2012，33，8： | 1 |
| 16 | The painlevé property for partial di?erential equations显示文摘 | Weiss J Tabor M Carnevale G | 1983 | J Math Phys1983，24，： | 1 |
| 17 | Minimal length tree networks on the unit sphere 显示文摘 | Dolan J Weiss R Smith J M G | 1991 | Annals of Operations Research1991，33，7： | 1 |
| 18 | Total knee arthoplasty in pateents with a prior fracture of lhe tibial plateau显示文摘 | Nicholsa G Weiss M Javad F | 2003 | J Bone Joint Surg(Am)2003，85，5： | 1 |
| 19 | Gallstone ileus: rare and still controversial显示文摘 | Kirchmayr W Muhlmann G Zitt M Bodner J Weiss H Klaus A | 2005 | ANZ J Surg2005，75，4： | 1 |
| 20 | Mining with rarity: A unifying framework 显示文摘 | Weiss G M | 2004 | ACM SIGKDD Explorations Newsletter-Special Issue on Lear- ning from Imbalaneed Datasets2004，6，1： | 1 |
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