|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Impact of co-infections with enteric pathogens on children suffering from acute diarrhea in southwest China显示文摘Background:Acute diarrhea is a global health problem,resulting in high morbidity and mortality in children.It has been suggested that enteric pathogen co-infections play an important role in gastroenteritis,but most research efforts have only focused on a small range of species belonging to a few pathogen groups.This study aimed to assess the impact of co-infections with a broad range of enteric pathogens on children aged below five years who suffer from acute diarrhea in southwest China.Method:A total of 1020 subjects(850 diarrhea cases and 170 healthy controls)were selected from four sentinel hospitals in Kunming,Yunnan province,southwest China,from June 2014 to July 2015.Stool specimens were collected to detect five virus(rotavirus group A,RVA;norovirus,NoV;Sapovirus,SaV;astrovirus,As;and adenovirus,Ad),seven bacterial(diarrheagenic Escherichia coli,DEC;non-typhoidal Salmonella,NTS;Shigella spp.;Vibrio cholera;Vibrio parahaemolyticus;Aeromonas spp.;and Plesiomonas spp.),and three protozoan(Cryptosporidium spp.,Giardia lamblia,and Blastocystis hominis,B.hominis)species using standard microbiologic and molecular methods.Data were analyzed using the partial least square regression technique and chi-square test.Results:At least one enteric pathogen was detected in 46.7%(n=397)of acute gastroenteritis cases and 13.5%(n=23)of healthy controls(χ^(2)=64.4,P<0.05).Single infection with RVA was associated with acute diarrhea(26.5%vs.5.8%,P<0.05).The prevalence of a single infection with B.hominis in diarrhea cases was higher than in healthy controls(3.1%vs.0.5%,OR=4.7,95%CI:1.01–112.0).Single infection with NoV GII was not associated with diarrhea(4.4%vs.3.5%,OR=1.2,95%CI:0.5–3.3).Single infections with bacterial species were not observed.The prevalence of co-infections with two enteric pathogens in diarrhea cases was higher than in asymptomatic children(20.1%vs.5.3%,P<0.05).RVA-NoV GII was the most common co-infection in symptomatic children(4.4%),with it aggravating the severity of diarrhea.Conclusions:Although it is clear that RVA has an overwhelming impact on diarrhea illnesses in children,co-infection with other enteric pathogens appears to also aggravate diarrhea severity.These findings should serve as evidence for public health services when planning and developing intervention programs. | Shun-Xian Zhang Yong-Ming Zhou Wen Xu Li-Guang Tian Jia-Xu Chen Shao-Hong Chen Zhi-Sheng Dang Wen-Peng Gu Jian-Wen Yin Emmanuel Serrano Xiao-Nong Zhou | 2016 | Infectious Diseases of Poverty2016，5，1： | 19 |
| 2 | Insulin enhances apoptosis induced by cisplatin in human esophageal squamous cell carcinoma EC9706 cells related to inhibition of autophagy显示文摘 | Yang Yang Wen Fengbiao Dang Lifeng Fan Yuxia Liu Donglei Wu Kai Zhao Song | 2014 | Chinese Medical Journal2014，，2： | 6 |
| 3 | Consensus on the digestive endoscopic tunnel technique显示文摘With the digestive endoscopic tunnel technique(DETT), many diseases that previously would have been treated by surgery are now endoscopically curable by establishing a submucosal tunnel between the mucosa and muscularis propria(MP). Through the tunnel, endoscopic diagnosis or treatment is performed for lesions in the mucosa, in the MP, and even outside the gastrointestinal(GI) tract.At present, the tunnel technique application range covers the following:(1)Treatment of lesions originating from the mucosal layer, e.g., endoscopic submucosal tunnel dissection for oesophageal large or circular early-stage cancer or precancerosis;(2) treatment of lesions from the MP layer, per-oral endoscopic myotomy, submucosal tunnelling endoscopic resection, etc.; and(3) diagnosis and treatment of lesions outside the GI tract, such as resection of lymph nodes and benign tumour excision in the mediastinum or abdominal cavity. With the increasing number of DETTs performed worldwide, endoscopic tunnel therapeutics, which is based on DETT, has been gradually developed and optimized. However, there is not yet an expert consensus on DETT to regulate its indications, contraindications, surgical procedure, and postoperative treatment.The International DETT Alliance signed up this consensus to standardize the procedures of DETT. In this consensus, we describe the definition, mechanism,and significance of DETT, prevention of infection and concepts of DETTassociated complications, methods to establish a submucosal tunnel, and application of DETT for lesions in the mucosa, in the MP and outside the GI tract(indications and contraindications, procedures, pre-and postoperative treatments, effectiveness, complications and treatments, and a comparison between DETT and other operations). | Ning-Li Chai Hui-Kai Li En-Qiang Linghu Zhao-Shen Li Shu-Tian Zhang Yu Bao Wei-Gang Chen Philip WY Chiu Tong Dang Wei Gong Shu-Tang Han Jian-Yu Hao Shui-Xiang He Bing Hu1 Bing Hu2 Xiao-Jun Huang Yong-Hui Huang Zhen-Dong Jin Mouen A Khashab James Lau Peng Li Rui Li De-Liang Liu Hai-Feng Liu Jun Liu Xiao-Gang Liu Zhi-Guo Liu Ying-Cai Ma Gui-Yong Peng Long Rong Wei-Hong Sha Pateek Sharma Jian-Qiu Sheng Shui-Sheng Shi Dong Wan Seo Si-Yu Sun Gui-Qi Wang Wen Wang Qi Wu Hong Xu Mei-Dong Xu Ai-Ming Yang Fang Yao Hong-Gang Yu Ping-Hong Zhou Bin Zhang Xiao-Feng Zhang Ya-Qi Zhai | 2019 | World Journal of Gastroenterology2019，25，7： | 5 |
| 4 | Pseudocayratia, a new genus of Vitaceae from China and 3apan with two new species and three new combinations显示文摘 | Jun wen Li-Min Lu Tsai-Wen Hsu Viet-Cuong Dang Sadaf Habibt John K. Boggan Hiroshi Okada I-Ju Chen Zhi-Duan Chen | 2018 | Journal of Systematics and Evolution2018，56，4： | 4 |
| 5 | Fabrication of niobium doped titanate nanoflakes with enhanced visible-light-driven photocatalytic activity for efficient ibuprofen degradation显示文摘In this study,a novel class of niobium(Nb) doped titanate nanoflakes(TNFs) are fabricated through a onestep hydrothermal method.Nb doping affects the curving of titanate nanosheet,leading to the formation of nanoflake structure.In addition,Nb5+ filled in the interlayers of [TiO6] alters the light adsorption property of pristine titanate.The band gap of Nb-TNFs is narrowed to 2.85 eV,while neat titanate nano tubes(TNTs) is 3.4 eV.The enhanced visible light adsorption significantly enhances the visible-lightdriven activity of Nb-TNFs for ibuprofen(IBP) degradation.The pseudo-first order kinetics constant for Nb-TNFs is calculated to be 1.04 h^-1,while no obvious removal is observed for TNTs.Photo-generated holes(h^+) and hydroxyl radicals(·OH) are responsible for IBP degradation.The photocatalytic activity of Nb-TNFs depends on pH condition,and the optimal pH value is found to be 5.In addition,Nb-TNFs exhibited superior photo-stability during the reuse cycles.The results demonstrated Nb-TNFs are very promising in photocatalytic water purification. | Wen Liu Wei Zhang Mushi Liu Penghui Du Chenyuan Dang Jialiang Liang Yunyi Li | 2019 | Chinese Chemical Letters2019，30，12： | 3 |
| 6 | Antiatherosclerotic effect of dehydrocorydaline on ApoE^(−/−) mice:inhibition of macrophage inflammation显示文摘Despite improvements in cardiovascular disease(CVD)outcomes by cholesterol-lowering statin therapy,the high rate of CVD is still a great concern worldwide.Dehydrocorydaline(DHC)is an alkaloidal compound isolated from the traditional Chinese herb Corydalis yanhusuo.Emerging evidence shows that DHC has anti-inflammatory and antithrombotic benefits,but whether DHC exerts any antiatherosclerotic effects remains unclear.Our study revealed that intraperitoneal(i.p.)injection of DHC in apolipoprotein E-deficient(ApoE^(-/-))mice not only inhibited atherosclerosis development but also improved aortic compliance and increased plaque stability.In addition,DHC attenuated systemic and vascular inflammation in ApoE^(-/-) mice.As macrophage inflammation plays an essential role in the pathogenesis of atherosclerosis,we next examined the direct effects of DHC on bone marrow-derived macrophages(BMDMs)in vitro.Our RNA-seq data revealed that DHC dramatically decreased the levels of proinflammatory gene clusters.We verified that DHC significantly downregulated proinflammatory interleukin(IL)-1βand IL-18 mRNA levels in a time-and concentration-dependent manner.Furthermore,DHC decreased lipopolysaccharide(LPS)-induced inflammation in BMDMs,as evidenced by the reduced protein levels of CD80,iNOS,NLRP3,IL-1β,and IL-18.Importantly,DHC attenuated LPS-induced activation of p65 and the extracellular signal-regulated kinase 1/2(ERK1/2)pathway.Thus,we conclude that DHC ameliorates atherosclerosis in ApoE^(-/-) mice by inhibiting inflammation,likely by targeting macrophage p65-and ERK1/2-mediated pathways. | Bin Wen Yuan-ye Dang Su-hua Wu Yi-min Huang Kong-yang Ma Yi-ming Xu Xi-Long Zheng Xiao-yan Dai | 2022 | Acta Pharmacologica Sinica2022，43，6： | 3 |
| 7 | Dual-targeting prodrug nanotheranostics for NIR-Ⅱfluorescence imaging-guided photo-immunotherapy of glioblastoma显示文摘Glioblastoma(GBM) therapy is severely impaired by the blood-brain barrier(BBB) and invasive tumor growth in the central nervous system.To improve GBM therapy,we herein presented a dual-targeting nanotheranostic for second near-infrared(NIR-Ⅱ) fluorescence imaging-guided photoimmunotherapy.Firstly,a NIR-Ⅱ fluorophore MRP bearing donor-acceptor-donor(D-A-D) backbone was synthesized.Then,the prodrug nanotheranostics were prepared by self-assembling MRP with a prodrug of JQ1(JPC) and T7 ligand-modified PEG5k-DSPE.T7 can cross the BBB for tumor-targeted delivery of JPC and MRP.JQ1 could be restored from JPC at the tumor site for suppressing interferon gamma-inducible programmed death ligand 1 expression in the tumor cells.MRP could generate NIR-Ⅱ fluorescence to navigate 808 nm laser,induce a photothermal effect to trigger in-situ antigen release at the tumor site,and ultimately elicit antitumor immunogenicity.Photo-immunotherapy with JPC and MRP dual-loaded nanoparticles remarkably inhibited GBM tumor growth in vivo.The dual-targeting nanotheranostic might represent a novel nanoplatform for precise photo-immunotherapy of GBM. | Fenglin Li Yi Lai Jiayi Ye Madiha Saeed Yijing Dang Zhifeng Zou Fangmin Chen Wen Zhang Zhiai Xu | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 2 |
| 8 | 非洲猪瘟病毒MGF110-9L和MGF505-7R双基因缺失株(ASFV-Δ9L/Δ7R)具有良好免疫保护效果显示文摘非洲猪瘟(ASF)是由ASF病毒(ASFV)感染引起的家猪和野猪的急性接触性传染病,强毒株感染致死率可达100%。ASF是世界动物卫生组织(WOAH)规定必须报告的动物传染病之一,也是我国规定的Ⅰ类传染病。2018年我国沈阳首次暴发ASF疫情,随着传播范围的扩大,我国的养猪业受到了沉重打击。该病首次于1921年在非洲肯尼亚发现,目前无商品化疫苗,急需研制安全、有效和质量可控的疫苗,基因缺失疫苗即是是其一。 | DING MING-YANG DANG WEN LIU HUA-NAN | 2022 | 中国预防兽医学报2022，44，12： | 2 |
| 9 | Evolutionary trends in Tetrastigma (Vitaceae): Morphological diversity and taxonomic implications显示文摘Tetrastigma (Miq ) Planch。(Vitaceae ) 是有 ca 的一个类。显示出大词法差异的 100 种类。以前的分子的种系发生的研究建议传统的分类系统不与分子的发展史一致,并且 Tetrastigma 正在经历进一步系统的调查。我们在一个柔韧的种系发生的框架以内跟踪了 20 个词法人物的进化趋势。我们的结果表明然而,许多词法人物显示出多重转变或很少状态变化一些人物出现不同变化。在 Tetrastigma 的二 subgenera (subgen。Tetrastigma 和 subgen。Palmicirrata ) 基于 unbranched/bifurcate 对有指地,分叉的卷须没被支持因为 subgen。Tetrastigma 是 paraphyletic。然而, unbranched 对 bifurcate/digitately 分叉卷须具有分类用途描绘一些主要 clades。在 Tetrastigma 的开花期显得腋,但是是压缩腋的射击上的 leafopposed。我们导出 pseudoumbellate 开花期的 clade IV 发现大多数在 Tetrastigma 的种类保留了祖先的复合 dichasial 开花期,除了那些。包括习惯,叶组织,和果浆形状的另外的人物为主要 clades 提供另外的词法支持。我们的词法分析和最近的分子的学习建议每在 Tetrastigma 以内的五主要 clades 被当作不同的分类的节(在类的五节) 。 | Sadaf Habib Viet-Cuong Dang Stefanie M. Ickert-Bond Jun Wen Zhi-Duan Chen Li-Min Lu | 2018 | Journal of Systematics and Evolution2018，56，4： | 2 |
| 10 | Comparative Study of care HPV Assay,Visual Inspection and Pap Smears as Primary Screening in Rural China显示文摘农村地区的肿瘤早诊早治,一直是国家肿瘤防治工作的重点。本文旨在研究在我国农村地区,在当地现实条件下由基层技术人员操作的醋酸碘染色肉眼观察、细胞学以及careHPV DNA检测的可行性。本研究中把当地参加项目的女性随机分为3组,分别采用醋酸碘染色肉眼观察、细胞学以及careHPV DNA进行宫颈癌及癌前病变的初筛。初筛阳性的女性转诊进行阴道镜及活检。所有的检测都是有当地工作人员完成。最终诊断以中国医学科学院肿瘤医院病理专家的结果为准。同时通过问卷调查收集筛查对象及乡医村医有关HPV及筛查项目的认知和态度。最终有894名女性完成careHPV DNA检测,552名女性完成醋酸碘染肉眼观察,547名女性完成巴氏涂片。careHPV检测、醋酸碘染肉眼观察和巴氏涂片的阳性率分别为10.6%,18.1%和4.9%,差异具有统计学意义(χ~2=48.647,P<0.001)。总人群的CIN2+病变检出率为0.5%,尽管careHPV组的CIN2+病变检出率高于其他两组,但差异未发现统计学意义。通过以上研究,显示基层卫生工作人员对HPV相关知识的了解不足,但对于在国家筛查项目中引入HPV检测持积极的态度。在基层条件下由经过简单培训的实验员进行careHPV检测是可行的,应在基层卫生工作者中开展HPV及其检测相关的教育和培训。 | Zhao Yuqian Dang Le Zhang Shaokai Hu Xiaofeng Zuo Tingting Chen Feng Zhang Xun Chen Wen Qiao Youlin | 2018 | 肿瘤预防与治疗2018，31，1： | 2 |
| 11 | Inducing and isolation of antibacterial peptides from oriental fruit fly, Bactrocera dorsalis Hendel显示文摘从一只使免疫的 dipteran 昆虫的一抗菌剂活动部分, Bactrocera 背面由 prepurification,离子交换层析,胶化过滤层析和反向阶段的高效液体层析(HPLC ) 是,被孤立并且净化。最后的净化的部分在聪明的系统 HPLC 上被检查并且被认为是纯部分。Theresults 物理并且生物检验表明这部分是热对克积极的细菌的生长的稳定、显示出的强壮的活动。它拥有 antibicrobial 肽性质并且值得进一步的调查。 | XIANG-LI DANG JIN-HUAN TIAN HUI-YU YI WEN-XIAN WANG MIN ZHENG YI-FENG LI YANG CAO SHUO-YANG WEN | 2006 | Insect Science2006，13，4： | 2 |
| 12 | Phylogeny and taxonomy of Afrocayratia,a new genus of Vitaceae from continental Africa and Madagascar显示文摘The genus Cayratia Juss.in the traditional sense(i.e.,Cayratia s.l.)of the grape family has been shown to be non-monophyletic.Previous studies supported the splitting of Cayratia s.l.into three genera,that is,Cayratia s.s.,Causonis Raf.,and a new genus representing the African Cayratia clade.However,the morphology of the African Cayratia clade has not been studied carefully and its phylogenetic position within Vitaceae remains unclear.Our study integrates molecular,distributional,and morphological data and supports the recognition of the new genus Afrocayratia from continental Africa and Madagascar.Phylogenetic analyses strongly support the monophyly of Afrocayratia and resolve it as a sister of Cayratia s.s.based on the chloroplast data,but it is placed sister to Cyphostemma based on the internal transcribed spacer dataset.Molecular dating suggests that Afrocayratia split with Cayratia s.s.during the Paleocene,but that the extant species of Afrocayratia did not diversify until the early Miocene.Afrocayratia differs from its allied genera in having short stigmas and seeds with subcircular ventral infold cavities in cross-section.Three clades are detected within Afrocayratia,with A.debilis(Baker)J.Wen&L.M.Lu as the first diverged lineage.The second diverged lineage includes A.delicatula(Willems)J.Wen&Z.D.Chen and A.gracilis(Guill.&Perr.)J.Wen&Z.D.Chen.The third diverged lineage includes A.imerinensis(Baker)J.Wen&L.M.Lu,A.longiflora(Desc.)J.Wen&Rabarijaona,and A.triternata(Baker)J.Wen&Rabarijaona from Madagascar,which form a monophyletic group that diverged from the second lineage in the middle Miocene.Combining the morphological and molecular evidence,we formally describe the new genus Afrocayratia,make seven new combinations,and provide a key to species of the genus. | Romer Narindra Rabarijaona Viet-Cuong Dang Gaurav Parmar Bing Liu Jun Wen Zhi-Duan Chen Li-Min Lu | 2020 | Journal of Systematics and Evolution2020，58，6： | 2 |
| 13 | A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1βand IL-6显示文摘Glycolytic metabolism enzymes have been implicated in the immunometabolism field through changes in metabolic status. PGK1 is a catalytic enzyme in the glycolytic pathway. Here, we set up a high-throughput screen platform to identify PGK1 inhibitors. DC-PGKI is an ATPcompetitive inhibitor of PGK1 with an affinity of Kd= 99.08 nmol/L. DC-PGKI stabilizes PGK1in vitro and in vivo, and suppresses both glycolytic activity and the kinase function of PGK1. In addition,DC-PGKI unveils that PGK1 regulates production of IL-1β and IL-6 in LPS-stimulated macrophages.Mechanistically, inhibition of PGK1 with DC-PGKI results in NRF2(nuclear factor-erythroid factor 2-related factor 2, NFE2L2) accumulation, then NRF2 translocates to the nucleus and binds to the proximity region of Il-1β and Il-6 genes, and inhibits LPS-induced expression of these genes. DC-PGKI ameliorates colitis in the dextran sulfate sodium(DSS)-induced colitis mouse model. These data support PGK1 as a regulator of macrophages and suggest potential utility of PGK1 inhibitors in the treatment of inflammatory bowel disease. | Liping Liao Wenzhen Dang Tingting Lin Jinghua Yu Tonghai Liu Wen Li Senhao Xiao Lei Feng Jing Huang Rong Fu Jiacheng Li Liping Liu Mingchen Wang Hongru Tao Hualiang Jiang Kaixian Chen Xingxing Diao Bing Zhou Xiaoyan Shen Cheng Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 2 |
| 14 | Fitting Characteristics of KS Function and its Application显示文摘 | ZHAO Wen - zhong DONG Pei - ming HE Wei - dang | 1993 | Computer Integrated Manufacturing1993，2，： | 1 |
| 15 | Interface behaviorof quaternized chitosan on cellulosic substrates 显示文摘 | YE W J DANG Y WEN X X | 2014 | Fibers and Polymers2014，15，7： | 1 |
| 16 | 1D Helix,2D Brick-Wall and Herringbone,and 3D Interpenetration d10 Metal Organic Framework Structures Assembled from Pyridine-2,6-dicarboxylic Acid N-Oxide显示文摘 | Wen Li-Li Dang Dong-Bin Duan Chun-Ying | 2005 | Inorg anic Chemisay2005，44，： | 1 |
| 17 | Current research and development of tissue engineered venous valve显示文摘 | Wen Y Li B Dang R S | 2008 | Chinese J Anat2008，31，3： | 1 |
| 18 | The Difficulties and Mechanism Innovation of Constructing China's Rural Multiplex Financial System显示文摘This paper expounds the necessity of constructing China's rural multiplex financial system as follows.First,overcome the bottleneck effect arising from the shortage of capital in the process of development of rural small and medium-sized enterprise,and increase farmers' income;second,provide capital support for rural modern industrial development,and promote rural economic development;third,rationally allocate capital,master the money flow and coordinate urban-rural development.The paper also profoundly analyzes the difficulties of constructing China's rural multiplex financial system as follows.First,the existing rural financial system structure is irrational and the function is unsound;second,non-governmental financial market is disorderly and the organization is unsound;third,the rural financial system is simple and the overhaul of rural credit cooperatives system has not yet been done;fourth,the construction of rural system of financial laws and regulations is laggard,and the construction of rural multiplex financial system lacks good social environment.The specific thoughts,measures and countermeasures of constructing mechanism innovation of China's rural multiplex financial system are put forward as follows.First,increasingly perfect legal system and provide legal support for constructing China's rural multiplex financial system;second,quicken the overhaul of rural credit cooperatives system and perfect its function in China's rural multiplex financial system;third,strengthen the degree of support and development,and change the situation of simple structure of rural financial system;fourth,reinforce administrative supervision and perfect public services,and standardize the rural financial market order. | DANG Wen Financial Department,Guangxi Economic Management Cadre College,Nanning 530007,China | 2011 | Asian Agricultural Research2011，3，5： | 1 |
| 19 | Essen- tial oil composition and larvicidal activity of Toddalia asiatica roots against the mosquito Aedes albopictus (Diptera: Culicidae) 显示文摘 | Xin Chao Liu Hui Wen Dang Ligang Zhou | 2013 | Parasitol Res2013，112，： | 1 |
| 20 | Studies on mechanoluminescence from SrAl 2 O 4 :Eu, Dy phosphor显示文摘 | Yuan-Hua Lin Zhimin Dang Yuan Deng Ce Wen Nan | 2002 | Materials Chemistry and Physics2002，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员