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| 1 | Effect of 5-FU on modulation of disarrangement of immune-associated cytokines in experimental acute pancreatitis显示文摘AIM:To investigate the effects of 5-Fluorouracil (5-FU) on modulation of pro-inflammatory and anti-inflammatory cytokines in acute pancreatitis and the mechanism of it in the treatment of acute pancreatitis.METHODS: Male Sprague Dawley rats were assigned to 3 Groups: Group A, sham operated rats as controls (n=7); Group B, acute pancreatitis induced by ductal injection with 5% sodium cholate at a volume of 1.0 mL/kg without any other treatment; Group C, after the pancreatitis was induced as in Group B, the rats were injected intravenously with 5-FU 40 mg/kg. The animals in Groups B and C were killed at 2, 6 and 24 h after operation (n=7), and blood samples were taken for measurement of tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6) (by bioas-say), and interleukin-10 (IL-10), transforming growth factor-β (TGF-β) (by ELISA). The wet weight of pancreatic tissue, serum amylase levels and white blood cells were also measured.RESULTS: Four rats in Group B and one in Group C died after pancreatitis was induced. Both pro-inflammatory cytokines (TNF-α, IL-1, IL-6) at the 2 and 6 h period and the anti-inflammatory cytokines (IL-10, TGF-β) at 24 h increased signif icantly (P<0.05) in rats of Group B. After treatment with 5-FU, TNF-α, IL-1, and IL-6 in serum of rats of Group C were inhibited at 2 and 6 h after operation (P<0.05), and IL-10, TGF-β were inhibited at 24 h compared to Group B (P<0.05). Obvious improvements in the severity of the acute pancreatitis, including the amylase levels, wet weight of pancreatic tissue and neutrophil counts, were also observed after treatment with 5-FU.CONCLUSION: 5-FU is an anti-metabolic and immu-nosuppressive agent which can minimize the abnormal immune cytokine response and relieve the pathophysiological disorders associated with experimental acute pancreatitis. | Xiao-Li Chen Sang-Zhu Ciren Hui Zhang Li-Geng Duan Alexander J Wesley | 2009 | World Journal of Gastroenterology2009，15，16： | 10 |
| 2 | Efficacy and safety of total parenteral nutrition in pediatric patients显示文摘 | Wesley J R | 1992 | Mayo Clin Proc1992，67，7： | 1 |
| 3 | Adjacent sequence controls the response polarity of nitric oxide-sensitive Sp factor binding sites 显示文摘 | Zhang J Wang S Wesley RA | 2003 | J Biol Chem2003，278，29： | 1 |
| 4 | Ventricular septal defect显示文摘 | Daniel J Penny G Wesley VickIII | 2011 | THE LANCET2011，377，9771： | 1 |
| 5 | Simulations of the origin of fluid pressure, fracture generation, and the movement of fluids in the Uinta Basin, Utah显示文摘 | BREDEHOEFT J D WESLEY J B FOUCH T D | 1994 | AAPG Bulletin1994，78，11： | 1 |
| 6 | Mesopomus material formed by acidic hydmthermal assembly of silicalit-eprecursor nanoparticles in the absence of meso-templales 显示文摘 | Wesley J S Vera M Erik B | 2008 | Micropomus and Mesopomus Material2008，100，1： | 1 |
| 7 | Differing determinants of prognosis following resection of pulmonary metastases from osteogenic and soft tissue sarcoma patients 显示文摘 | Roth J A Putnam J B Wesley M N | 1985 | Cancer1985，55，6： | 1 |
| 8 | NCEP-DOE AMIP-II reanalysis (R-2) 显示文摘 | Kanamitsu M Wesley E Woolen J | 2002 | Bull Amer Meteor Soc2002，83，： | 1 |
| 9 | Process and Equipment Monitoring Methodologies Applied to Sensor Calibration Monitoring显示文摘 | Wesley Hines J Dustin Garvey | 2007 | Quality and Reliability Engineering International2007，23，： | 1 |
| 10 | Simulations of the origin of fluid pressure,fracture generation and the movement of fluid in the Uinta basin, Utah 显示文摘 | Bredehoeft J D Wesley J B Fouch T D | 1994 | AAPG Bulletin1994，78，： | 1 |
| 11 | Ca2+-Mg2+-activated ATPase in the shell gland of Japanese quail(Coturnix coturnix Japonica)显示文摘 | Wesley Pike J Alvarado R H | 1975 | Comp Biochem Physiol Part B:Comp Biochem1975，51，1： | 1 |
| 12 | Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization显示文摘 | Lieben Liesbet Masuyama Ritsuko Torrekens Sophie Van Looveren Riet Schrooten Jan Baatsen Pieter Lafage-Proust Marie-Hélène Dresselaers Tom Feng Jian Q Bonewald Lynda F Meyer Mark B Pike J Wesley Bouillon Roger Carmeliet Geert | 2012 | EN2012，，5： | 1 |
| 13 | Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia 显示文摘 | BOSCH-MARCE M OKUYAMA H WESLEY J B | 2007 | Circ Res2007，101，12： | 1 |
| 14 | Recombinant adenovirus encoding the HA gene from swine H3N2 influenza virus partially protects mice from challenge with heterologous virus:A/HK/1/68 (H3N2)显示文摘 | Harp J A Wesley R D | 2004 | Archives of Virology2004，147，11： | 1 |
| 15 | Prevalence of pathogenic Yersinia enterocolitica strains in pigs in the United States显示文摘 | BHADURI S WESLEY l V BUSH E J | 2005 | Applied and Environmental Microbiology2005，71，11： | 1 |
| 16 | Dimensions of Consumer Expertise显示文摘 | ALBA JOSEPH W WESLEY HUTCHINSON J | 1987 | Journal of Consumer Re-search1987，13，3： | 1 |
| 17 | Mantrala ( 1994 ), Finding choice alternatives in memory: probability models of brand name recall显示文摘 | Hutchinson J Wesley Kalyan Raman and Murali K | 1994 | Journal of Marketing Research1994，31，： | 1 |
| 18 | Solving the pickup and delivery problem with time windows using reactive tabu search 显示文摘 | WILLIAM P NANRY J WESLEY B | 2000 | Transportation Research Part B2000，34，2： | 1 |
| 19 | Non-invasive monitoring of dough mixing by near infrared spectroscopy 显示文摘 | Wesley I J Larsen N Osborne B G Skerritt J H | 1998 | Journal of Cereal Science1998，27，： | 1 |
| 20 | A randomized attempt to increase the efficacy of cytotoxic chemotherapy in metastatic breast cancer by hormonal synchronization显示文摘 | Cassidy J Wesley M | 1984 | J Clin Oncol1984，2，1： | 1 |
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