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| 1 | Causal relationship between hypoalbuminemia and acute kidney injury显示文摘Our meta-analysis published in 2010 provided evidence that low levels of serum albumin(hypoalbuminemia) are a significant independent predictor of acute kidney injury(AKI) and death following AKI.Since then,a large volume of additional data from observational clinical studies has been published further evaluating the relationship between serum albumin and AKI occurrence.This is an updated review of the literature to re-evaluate the hypothesis that hypoalbuminemia is independently associated with increased AKI risk.Eligible studies published from September 2009 to December 2016 were sought in PubM ed(MEDLINE) and forty-three were retained,the great majority being retrospective observational cohort studies.These included a total of about 68000 subjects across a diverse range of settings,predominantly cardiac surgery and acute coronary interventions,infectious diseases,transplant surgery,and cancer.Appraisal of this latest data set served to conclusively corroborate and confirm our earlier hypothesis that lower serum albumin is an independent predictor both of AKI and death after AKI,across a range of clinical scenarios.The body of evidence indicates that hypoalbuminemia may causally contribute to development of AKI.Furthermore,administration of human albumin solution has the potential to prevent AKI;a randomized,controlled study provides evidence that correcting hypoalbuminemia may be renal-protective.Therefore,measurement of serum albumin to diagnose hypoalbuminemia may help identify high-risk patients who may benefit from treatment with exogenous human albumin.Multi-center,prospective,randomized,interventional studies are warranted,along with basic research to define the mechanisms through which albumin affords nephroprotection. | Christian J Wiedermann Wolfgang Wiedermann Michael Joannidis | 2017 | World Journal of Nephrology2017，6，4： | 15 |
| 2 | Effects of anticoagulant strategies on activation of inflammation and coagulation 显示文摘 | Feistritzer C Wiedermann CJ | 2007 | Expert Opin Biol Ther2007，7，6： | 1 |
| 3 | Central nervous system inflammatory response after cerebral infarction as detected by magnetic resonance imaging 显示文摘 | Saleh A Wiedermann D Schroeter M | 2004 | NMR in biomedicine2004，17，4： | 1 |
| 4 | Association of endotoxemia with carotid atherosclerosis and cardiovascular disease: prospective results from a large population study 显示文摘 | Wiedermann C J Kiechl S Dunzendorfer S | 1999 | J Am Coll Cardiol1999，34，： | 1 |
| 5 | Theoretical basis for the activity of thalidomide显示文摘 | Mererhofer C Dunzendoffer S Wiedermann CJ | 2001 | Bio Drugs2001，15，10： | 1 |
| 6 | Treatment effects of high - dose antithrombin without concomitant heparin in patients with severe sepsis with or without disseminated intravascular coagulation 显示文摘 | Kienast J Juers M Wiedermann C J | 2006 | J Thromb Haemost2006，4，1： | 1 |
| 7 | The oretical basis for the activity of thalidomide 显示文摘 | Meierhofer C Dunzendorfer S Wiedermann CJ | 2001 | Bio Drugs2001，15，10： | 1 |
| 8 | Expression and function of the angiopoietin receptor Tie-2 in human eosinophils 显示文摘 | Feistritzer C Mosheimer BA Sturn DH Bijuklic K Patsch JR Wiedermann CJ | 2004 | J Allergy Clin Immunol2004，114，5： | 1 |
| 9 | Toll-like receptor4 and atherogenesis显示文摘 | KIECHL S WIEDERMANN CJ WILLEIT J | 2003 | Ann Med2003，35，3： | 1 |
| 10 | Anti - inflammatory effects of the antibiotics ceftazidime and tobramycin in porcine endotoxin shock: are they really anti- inflammatory? 显示文摘 | Wiedermann FJ | 2004 | Crit Care2004，8，2： | 1 |
| 11 | Renal impairment in cardiac surgery patients receiving hydroxyethyl starch显示文摘 | | 2004 | Intensive Care Med2004，30，3： | 1 |
| 12 | Does fentanyl-induced cough justify pre-treatment with iv lidocaine 2 mg/kg显示文摘 | Schlimp CJ Wiedermann FJ | 2005 | 52:2072005，52，： | 1 |
| 13 | Transcription factors associated with epithelial-mesenchymal transition and cancer stem cells in the tumor centre and margin of invasive breast cancer显示文摘 | ALKATOUT I WIEDERMANN M BAUER M | 2013 | Exp Mol Pathol2013，94，1： | 1 |
| 14 | Endothelial protein C receptor-dependent inhibition of human eosinophil chemotaxis by protein C显示文摘 | Clemens Feistritzer Daniel H Sturn Nicole C Kaneider Angela Djanani Christian J Wiedermann | 2003 | The Journal of Allergy and Clinical Immunology2003，，2： | 1 |
| 15 | Rapid production of recombinant allergen in Nicotiana benthamiana and their impact on diagnosis and therapy 显示文摘 | BREITENEDER H KREBITZ M WIEDERMANN U | 2001 | Int Arch Allergy Immunol2001，124，13： | 1 |
| 16 | Differences in pharmacokinctics of amphotericin B lipid formulations despite clinical equivalence显示文摘 | Bellmann R Egger P Wiedermann C J | 2003 | Clin Inf Dis2003，36，： | 1 |
| 17 | Effect of high-dose iutracoronary irradiation of vasomotor function and smooth muscle hitopathology 显示文摘 | Leavy IA Amols H | 1994 | Am J Physiol1994，267，： | 1 |
| 18 | Immunorestoration in children with respiratory infection treated with isoprinosie显示文摘 | Wiedermann D lokaj J | 1997 | Int J Immunopharm1997，8，： | 1 |
| 19 | Migration of humanmonocytes in response to procalcitonin 显示文摘 | Wiedermann FJ Kaneider N Egger P | 2002 | Crit Care Med2002，30，5： | 1 |
| 20 | Reliability and spatial specificity of rat brain sensorimotor functional connectivity networks are superior under sedation compared with general anesthesia显示文摘 | Kalthoff D Po C Wiedermann D | 2013 | NMR Biomed2013，26，6： | 1 |
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