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| 1 | Liver natural killer cells: subsets and roles in liver immunity显示文摘肝代表常常由于它的唯一的地点和血供应暴露于许多导出勇气的抗原的一个前线免疫者机关。与在天生的豁免的一个占优势的角色,肝与各种各样的天生的有免疫力的房间,在天赋之中,杀手(NK ) 房间在主人辩护并且在维持有免疫力的平衡起重要作用被充实。肝的 NK 房间首先被描述为 ‘坑 cells’在在 1970 年代的老鼠肝。在老鼠和人的肝的 NK 房间的最近的研究显示出那二个不同 NK 房间子集,肝居民 NK 房间和常规 NK (cNK ) 房间,在这个机关是在场的。这里,我们在不同种类考察肝 NK 细胞子集,重游老鼠与在老鼠和人的肝的居民 NK 细胞有关的肝的坑细胞和加亮的最近的进步,并且也在肝免疫讨论 NK 细胞的双角色。 | Hui Peng Eddie Wisse Zhigang Tian | 2016 | Cellular & Molecular Immunology2016，13，3： | 34 |
| 2 | 3种不同焦油卷烟烟气的细胞毒性比较显示文摘采用中性红法测定了K2R4F参比卷烟和15、8和3mg/支焦油市售国产混合型卷烟烟气的细胞毒性。即卷烟主流烟气经洁净空气稀释后直接导入BALB/c3T3细胞培养瓶中染毒,而后采用中性红法测定细胞毒性,并计算出基于烟气总粒相物的相对细胞死亡率和LC50。结果表明:4种卷烟的细胞毒性依次为15mg/支焦油卷烟>>8mg/支焦油卷烟≈K2R4F>3mg/支焦油卷烟,与这3种国产卷烟样品烟气气相自由基、烟草特有N-亚硝胺和稠环芳烃的降低一致。说明卷烟减害降焦,可以降低其烟气的细胞毒性,降低吸烟对健康的危害。 | 卢斌斌 Ryan Meng Lynne Wisse 焦延福 | 2007 | 烟草科技2007，40，12： | 17 |
| 3 | On the cell biology of pit cells,the liver-specific NK cells显示文摘INTRODUCTION Natural killer (NK) cells are functionally defined by their ability to kill certain tumor cells and virus-infected cells without prior | Luo DZ Vermijlen D Ahishali B Triantis V Plakoutsi G Braet F Vanderkerken K Wisse E | 2000 | World Journal of Gastroenterology2000，6，1： | 8 |
| 4 | Participation of CD45,NKR-P1A and ANK61 antigen in rat hepatic NK cell(pit cell)-mediated target cell cytotoxicity显示文摘AIM Several triggering receptors have beendescribed to be involved in natural killer(NK)cell-mediated target cytotoxicity.In these studies,NKcells derived from blood or spleen were used.Pitcells are liver-specific NK cells that possess ahigher level of natural cytotoxicity and a differentmorphology when compared to blood NK cells.The aim of this study was to characterize the roleof the NK-triggering molecules NKR-P1A,ANK61antigen,and CD45 in pit cell-mediated killing oftarget cells.METHODS 51Cr-release and DNA fragmentationwere used to quantify target cell lysis andapoptosis,respectively.RESULTS Flow cytometric analysis showed thatpit cells expressed CD45,NKR-P1A,and ANK61antigen.Treatment of pit cells with monoclonalantibody(mAb)to CD45(ANK74)not onlyinhibited CC531s or YAC-1 target lysis but alsoapoptosis induced by pit cells.The mAbs to NKR-P1A(3.2.3)and ANK61 antigen(ANK61)had no effect on pit cell-mediated CC531s or YAC-1 targetcytolysis or apoptosis,while they did increase theFcγ receptor positive(FcγR+)P815 cytolysis andapoptosis.This enhanced cytotoxicity could beinhibited by 3,4-dichloroisocoumarin,an inhibitorof granzymes.CONCLUSION These results indicate that CD45participates in pit cell-mediated CC531s and YAC-1target cytolysis and apoptosis.NKR-P1A andANK61 antigen on pit cells function as activationstructures against FcγR+ P815 cells,which wasmediated by the perforin/granzyme pathway. | David Vermiilen Bülent Ahishali Vasilis Triantis Karin Vanderkerken Peter J. K.Kuppen Eddie Wisse | 2000 | World Journal of Gastroenterology2000，6，4： | 4 |
| 5 | The hepatic sinusoidal endothelial lining and colorectal liver metastases显示文摘Colorectal cancer (CRC) is a common malignant disease and the severe nature of cases in men and women who develop colorectal cancer makes this an important socio-economic health issue. Major challenges such as understanding and modeling colorectal cancer pathways rely on our understanding of simple models such as outlined in this paper. We discuss that the development of novel standardized approaches of multidimensional (correlative) biomolecular microscopy methods facilitates the collection of (sub) cellular tissue information in the early onset of colorectal liver metastasis and that this approach will be crucial in designing new effective strategies for CRC treatment. The application of X-ray micro-computed tomography and its potential in correlative imaging of the liver vasculature will be discussed. | Filip Braet Keissuke Nagatsuma Masaya Saito Lilian Soon Eddie Wisse Tomokazu Matsuura | 2007 | World Journal of Gastroenterology2007，13，6： | 3 |
| 6 | Estimation of Time to Maximum Rate Under Adiabatic Conditions(TMR_(ad)) Using Kinetic Parameters Derived From DSC-Investigation of Thermal Behavior of 3-Methyl-4-Nitrophenol显示文摘Kinetic parameters of the decomposition of hazardous chemicals can be applied for the estimation of their thermal behavior under any temperature profile.Presented paper describes the application of the advanced kinetic approach for the determination of the thermal behavior also under adiabatic conditions occurring e.g.in batch reactors in case of cooling failure.The kinetics of the decomposition of different samples(different manufacturers and batches) of 3-methyl-4-nitrophenol were investigated by conventional DSC in non-isothermal(few heating rates varying from 0.25 to 8.0K/min) and isothermal(range of 200~260℃) modes.The kinetic parameters obtained with AKTS-Thermokinetics Software were applied for calculating reaction rate and progress under different heating rates and temperatures and verified by comparing simulated and experimental signals.After application of the heat balance to compare the amount of heat generated during reaction and its removal from the system,the knowledge of reaction rate at any temperature profiles allowed the determination of the temperature increase due to the self-heating in adiabatic and pseudo-adiabatic conditions.Applied advanced kinetic approach allowed simulation the course of the Heat-Wait-Search(HWS) mode of operation of adiabatic calorimeters.The thermal safety diagram depicting dependence of Time to Maximum Rate(TMR) on the initial temperature was calculated and compared with the results of HWS experiments carried out in the system with Ф-factor amounting to 3.2.The influence of the Ф-factor and reaction progress reached at the end of the HWS monitoring on the TMR is discussed.Presented calculations clearly indicate that even very minor reaction progress reduces the TMRad of 24h characteristic for a sample with initial reaction progress amounting to zero.Described estimation method can be verified by just one HWS-ARC,or by one correctly chosen ISO-ARC run of reasonable duration by knowing in advance the dependence of the TMR on the initial temperature for any Ф-factor.Proposed procedure results in significant shortening of the measuring time compared to a safety hazard approach based on series of ARC experiments carried out at the beginning of a process safety evaluation. | Bertrand Roduit Patrick Folly Alexandre Sarbach Beat Berger Franz Brogli Francesco Mascarello Mischa Schwaninger Thomas Glarner Eberhard Irle Fritz Tobler Jacques Wiss Markus Luginbühl Craig Williams Pierre Reuse Francis Stoessel | 2011 | 化学推进剂与高分子材料2011，9，1： | 3 |
| 7 | Nanostructured lipid matrices for improved microencapsulation of drugs显示文摘 | R.H Müller M Radtke S.A Wissing | 2002 | International Journal of Pharmaceutics2002，，1： | 2 |
| 8 | Nanostructured lipid matrices for improved microencapsulation of drugs 显示文摘 | Muller RH Radtke M Wissing SA | 2002 | Int J Pharm2002，242，12： | 2 |
| 9 | Nanostructured lipid matrices for improved microencapsulation of drugs显示文摘 | R.H Müller M Radtke S.A Wissing | 2002 | International Journal of Pharmaceutics2002，，1： | 2 |
| 10 | Solid lipid nanoparticles(SLN) and nanostructured lipid carriers(NLC) in cosmetic and dermatological preparations 显示文摘 | MILLER RH RADTKE M WISSING SA | 2002 | Adv Drug Deliv2002，54，1： | 1 |
| 11 | Neurocutaneous disorders:Tuberous sclerosis,incontinentia pigmenti,and hypomelanosis of Ito显示文摘 | Wiss K | 1992 | Semin Neurol1992，12，4： | 1 |
| 12 | Open reduction and internal fixation of tibial plafond fractures:variables contributing to poor results and complications显示文摘 | Teeny SM Wiss DA | 1993 | Clin Orthop1993，，292： | 1 |
| 13 | Solid lipid nanop- articles (SLN) and nanostructured lipid carriers (NLC) in cos- metic and dermatological preparations 显示文摘 | MULLER R H RADTKE M WISSING S A | 2002 | Adv Drug Deliv Rev2002，54，1： | 1 |
| 14 | Artemisia arborescens L essential oil-loaded solid lipid nanoparticles for potential agricultural application : preparation and characterization 显示文摘 | LAI F WISSING SA MULLER RH | 2006 | AAPS Pharm Sci Tech2006，7，1： | 1 |
| 15 | Validation of the Values in Action Inventory of Strengths for Youth (VIA-Youth) among South African learners显示文摘 | Van Eeden C Wissing M | 2008 | Journal of Psychology in Africa2008，18，1： | 1 |
| 16 | Posterior fracture dislocation of the hip with fractures of the femoral head显示文摘 | Epstein HC Wiss DA Cozen L | 1985 | Clin Orthop Relat Res1985，，201： | 1 |
| 17 | The pit cell: description of a new type of cell occurring in rat liver sinusoids and peripheral blood显示文摘 | Wisse E van Noordende J M van der Meulen J | 1976 | Cell Tissue Res1976，173，： | 1 |
| 18 | Unstable fractures of the tibia treated with a reamed intramedullary interlocking nail显示文摘 | Wiss DA Stetson WB | 1995 | Clin Orthop Relat Res1995，，315： | 1 |
| 19 | An AIF orthologue regulates apoptosis in yeast显示文摘 | WISSING S LUDOVICO P HERKER E | 2004 | J Cell Biol2004，，166： | 1 |
| 20 | Regeneration of nitrogen and phosphorus by bluegill and gizzard shad: effect of feeding history 显示文摘 | Mather M E Vanni M J Wissing T E | 1995 | Canadian Journal of Fisheries and Aquatic Sciences1995，52，： | 1 |
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