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| 1 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 2 | ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn's disease patients显示文摘AIM:To investigate if the presence of relevant genetic polymorphisms has effect on the effectual clearance of bacteria by monocytes and granulocytes in patients with Crohn’s disease(CD).METHODS:In this study,we assessed the differential responses in phagocytosis by measuring the phagocytic activity and the percentage of active phagocytic monocytes and granulocytes in inflammatory bowel disease patients as well as healthy controls.As both autophagy related like 1(ATG16L1)and immunityrelated guanosine triphosphatase gene are autophagy genes associated with CD and more recently nucleo-tide-binding ligomerization domain-containing protein2(NOD2)has been identified as a potent inducer of autophagy we genotyped the patients for these variants and correlated this to the phagocytic reaction.The genotyping was done with restriction fragment length polymorphisms analysis and the phagocytosis was determined with the pHrodo?Escherichia coli Bioparticles Phagocytosis kit for flowcytometry.RESULTS:In this study,we demonstrate that analysis of the monocyte and granulocyte populations of patients with CD and ulcerative colitis showed a comparable phagocytic activity(ratio of mean fluorescence intensity)between the patient groups and the healthy controls.CD patients show a significantly higher phagocytic capacity(ratio mean percentage of phagocytic cells)compared to healthy controls(51.91%±2.85%vs 37.67%±7.06%,P=0.05).The extend of disease was not of influence.However,variants of ATG16L1(WT:2.03±0.19 vs homozygoot variant:4.38±0.37,P<0.009)as well as NOD2(C-ins)(heterozygous variant:42.08±2.94 vs homozygous variant:75.58±4.34(P=0.05)are associated with the phagocytic activity in patients with CD.CONCLUSION:Monocytes of CD patients show enhanced phagocytosis associated with the presence of ATG16L1 and NOD2 variants.This could be part of the pathophysiological mechanism resulting in the disease. | Simone CS Wolfkamp Caroline Verseyden Esther WM Vogels Sander Meisner Kirsten Boonstra Charlotte P Peters Pieter CF Stokkers Anje A te Velde | 2014 | World Journal of Gastroenterology2014，20，10： | 2 |
| 3 | 高密度脂蛋白可追踪脑卒中恢复情况显示文摘前瞻性队列研究质疑高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)在脑卒中风险预测中的价值。该文旨在探讨长期功能恢复与高密度脂蛋白(high density lipoprotein,HDL)蛋白质组和功能的关系。方法与结果:测定急性缺血性脑卒中后2个时间点(24小时,35例;96小时,20例)和35例对照组HDL蛋白组成和功能(胆固醇流出能力)的变化。 | Plubell DL Fenton AM Rosario S Bergstrom P Wilmarth PA Clark WM Zakai NA Quinn JF Minnier J Alkayed NJ Fazio S Pamir N 刘青(译) 刘莉(摘/审校) | 2020 | 中华高血压杂志2020，28，11： | 2 |
| 4 | Variation in color between intended matched shade and fabricated shade of dental porcelain显示文摘 | Monaghan P Johnston WM | 2002 | J Prosthet Dent2002，87，6： | 1 |
| 5 | Contemparary management of acute mesenterie ischemia: factors associated with survival 显示文摘 | Park WM Cloviezki P Cherry KJ Jr | 2002 | Vasc Surg2002，35，： | 1 |
| 6 | China, exploring critical success factors of partnering in construction projects 显示文摘 | Albert P C Dnaiel WM | 2004 | Journal of Construction Engineering and Management2004，，6： | 1 |
| 7 | Catheter ablation of cardiac autonomic nerves for prevention of vagal atrial fibrillation显示文摘 | Schauerte P Scherlag BJ Jackman WM | 2000 | Circuhtion2000，102，22： | 1 |
| 8 | Hepatitis B virus infection:current status显示文摘 | Ocama P Opio CK Lee WM | 2005 | Am J Med2005，118，12： | 1 |
| 9 | Contemporary management of acute mesenteric ischemia:Factors associated with survival显示文摘 | ParK WM Cloviczki P Cherry KJ | 2002 | J Vasc Surg2002，35，3： | 1 |
| 10 | Electromyographic analysis of upperbody, lower body, and abdominal muscles during advancedSwiss ball exercises 显示文摘 | WM M P IMTIAZ D | 2010 | J Strength Cond Res2010，24，6： | 1 |
| 11 | Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD显示文摘 | Bernhardt wM wiesener MS Scigalla P | | 0，，： | 1 |
| 12 | Invasive breast cancer:carrelation of dynamic MR features with prognostic factors显示文摘 | Szabo BK Aspelin P Kristoffersen WM | 2003 | Eur Radiol2003，13，11： | 1 |
| 13 | Differential regulation of mRNAs for GDNF alpha after sciatic nerve lesion in the mouse显示文摘 | Navelihan P El Shamy WM Ernfors P | 1997 | Eur J Neur o Sci1997，9，5： | 1 |
| 14 | Occupational exposure to antineoplastic agents:Self-reported miscarriages and stillbirths among nurses and pharmacists显示文摘 | Valanis B Vollemr WM Steele P | 1999 | Occup Environ Med1999，41，8： | 1 |
| 15 | New concepts and new design of permanent maglev rotary artificial heart blood pumps显示文摘 | Qian KX Zeng P Ru WM | 2006 | Medical Engineering & Physics2006，28，： | 1 |
| 16 | Autophagy and the immune system显示文摘 | Kuballa P Nolte WM Castoreno AB | 2012 | Annu Rev Immunol2012，30，： | 1 |
| 17 | TheWnt/frizzled/GSK-3p pathway : a novel therapeutic target forcardiac hypertrophy 显示文摘 | Blankesteijn WM van de Schans VA ter Horst P | 2008 | Trends Pharmacol Sci2008，29，4： | 1 |
| 18 | Incidence and short-term outcome of acute lung injury in mechanically ventilated children显示文摘 | Dahlem P van Aalderen WM Hamaker ME | 2003 | Eur Respir J2003，22，： | 1 |
| 19 | Incidence of opportunistic and other in-fections in HIV-infected children in the HAART era显示文摘 | Gona P Van Dyke RB Williams PL Dankner WM Chemcff MC Nachman SA | 2006 | JAMA2006，296，3： | 1 |
| 20 | Functional proteomic analysis of protein kinase C epsilon signaling complexes in the normal heart and during cardioprotection 显示文摘 | Zhang J Pierce WM Jr | 2001 | Circ Res2001，88，1： | 1 |
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