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| 1 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 2 | The dimen-sionality of the Maslach Burnout Inventory across small business owners and educators 显示文摘 | BOLES J S DEAN D H XAVIER J M R | 2000 | Journal of Vocational Behavior2000，，： | 1 |
| 3 | Development of 177Ln- nanobodies for radioimmunotherapy of HER2-positive breast cancer: evaluation of different bifunctional chelators 显示文摘 | D'Huyvetter M Aerts A Xavier C | 2012 | Contrast Media Mol Imaging2012，7，： | 1 |
| 4 | Synthesis, preelini- cal validation, dosimetry, and toxicity of 68 Ga-NOTA-anti-ttER2 nanobodies for iPET imaging of HER2 receptor expression in cancer 显示文摘 | Xavier C Vaneycken I D'huyvetter M | 2013 | J Nucl Med2013，54，： | 1 |
| 5 | Effects of the vitamin E in catalase activities in hippocampus after status epi- lepticus induced by pilocarpine in wistar rats显示文摘 | Barros D O Xavier S M L Barbosa C O etal | 2007 | Neuroscencei Letters2007，416，3： | 1 |
| 6 | Zeolite as efficient catalysts for key transformations in carbohydrate chemistry 显示文摘 | Xavier Nuno M Lucas Susana D Rauter Amelia P | 2009 | Journal of Molecular Catalysis A: Chemical2009，305，12： | 1 |
| 7 | Risk factors forischaemic and intracerebral haemorrhagic stroke in 22countries(the INTERSTROKE study):a case-controlstudy显示文摘 | O'Donnell M J Xavier D Liu L | 2010 | The Lancet2010，376，9735： | 1 |
| 8 | Risk factors for ischaemic and intraeerebral haemurrhagic stroke in 22 countries ( the INTERSTROKE study) :a case-control study 显示文摘 | ODonnell M J Xavier D Liu L | 2010 | Lancet2010，376，9735： | 1 |
| 9 | The effect of remifentanil on the bispectral index change and hemodynamic responses after orotracheal intubation 显示文摘 | Bruno G Christophe M Xavier D | 2000 | Anesth Analg2000，90，1： | 1 |
| 10 | Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study显示文摘 | O'Donnell M J Xavier D Liu L | 2010 | Lancet2010，376，9735： | 1 |
| 11 | Cell death in human lung transplantation:apoptosis induction in human lung during ischemic and after transplantation显示文摘 | Fisher S Cassivi S D Xavier A M | 2000 | Ann Thorac Surg2000，231，： | 1 |
| 12 | The dimensionality of the Maslach Burnout Inventory across small business owners and educators显示文摘 | Boles J S Dean D H Xavier J M R Short J C Wang G P | 2000 | Journal of Vocational Behavior2000，56，： | 1 |
| 13 | Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the 1NTERSTROKE study):a case-control study显示文摘 | O'Donnell M J Xavier D Liu L | 2010 | Lancet2010，376，： | 1 |
| 14 | Rationale and design of INTERSTROKE:aglobal case-control study of risk factors for stroke显示文摘 | O’DONNELL M XAVIER D DIENER C | 2010 | Neuroepidemiology2010，35，1： | 1 |
| 15 | Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries(the INTERSTROKE study):a case-control study显示文摘 | O'Donnell M J Xavier D Liu L | 2010 | Lancet2010，376，： | 1 |
| 16 | The effect of remifentanil on the bispectral index change and hemodynamic response after orotracheal intubation显示文摘 | Bruno G Christophe M Xavier D | 2000 | Anesth Analg2000，90，1： | 1 |
| 17 | Low-level laser therapy (LLLT: 780 nm) acts differently on mRNA expression of antiand pro-inflammatory mediators in an experimental model of eollagenase-indueed tendinitis in rat显示文摘 | Pires D Xavier M Araujo T | 2011 | Lasers Med Sci2011，26，1： | 1 |
| 18 | Fiber optic monitoring of carbamate pesticides using porous glass with covalently bound chlorophenol red显示文摘 | Xavier M P Vallejo B Marazuela M D | 2000 | Biosensot and Bioelectronics2000，14，12： | 1 |
| 19 | Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22countries(the INTERSTROKE study):a case-control study显示文摘 | O'DONNELL M J XAVIER D LIU Lisheng | 2010 | Lancet2010，376，9735： | 1 |
| 20 | Development of 177Lu- nanobodies for radioimmunotherapy of HER2-positive breast cancer: evaluation of different bifunctional chelators 显示文摘 | D'Huyvetter M Aerts A Xavier C | 2012 | Contrast Media Mol Imaging2012，7，： | 1 |
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