|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis显示文摘AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separate model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in China.Hypothetical 50-year-old individuals were followed until age 80 or death.We compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an HRME.Model parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer database.Health states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and death.Separate ESCC incidence transition rates were generated for the average-risk and high-risk populations.Costs in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price Index.RESULTS:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY gained.Standard endoscopic screening was weakly dominated.Among the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per QALY.For both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per QALY.One-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s iodine(>40%)and lower specificity of HRME(<70%)could make Lugol’s iodine screening cost-effective.For the high-risk population,the results of the model were not substantially affected by varying the follow-up rate after Lugol’s iodine screening,Lugol’s iodine test characteristics(sensitivity and specificity),or HRME specificity.CONCLUSION:The incorporation of HRME into an ESCC screening program could be cost-effective in China.Larger studies of HRME performance are needed to confirm these findings. | Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy | 2015 | World Journal of Gastroenterology2015，21，18： | 8 |
| 2 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 3 | Src homology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activity- and PI-3K-independent mechanism显示文摘 | An H Xu H Zhang M Zhou J Feng T Qian C Qi R Cao X | 2006 | 第二军医大学学报2006，27，1： | 6 |
| 4 | 甜菜碱对肥育猪生长激素脉冲释放和血清代谢的影响显示文摘用添加含量为0和0.125%甜菜碱的日粮饲喂肥育猪,试验对杂交肥育猪日粮中甜菜碱对猪的生长性能、生长激素(GH)脉冲释放及血清代谢的影响进行研究。每试验组3个重复,每个重复8头猪(4头去势公猪,4头母猪),试验在饲喂后3h内每15min采集一次血液样本,测定生长激素脉冲释放。结果表明:添加甜菜碱组平均日增重增加5.45%(P〈0.05),而平均日采食量和饲料转化率则不受影响。 | Huang Q C Xu Z R Han X Y Li W F | 2007 | 饲料博览(技术版)2007，，7： | 2 |
| 5 | Glucocorticoid receptor and protein/RNA synthesis-dependent mechanisms underlie the control of synaptic plasticity by stress显示文摘 | Xu L Holscher C Anwyl R Rowan M J | 1998 | Proc Natl Acad USA1998，95，： | 1 |
| 6 | Photoeatalytic effect of carbon modified n TiO2 nanoparticles under visible light illumination显示文摘 | Xu C Killmeyer R Gray M | 2006 | Appl Catal B2006，64，： | 1 |
| 7 | Description of distributed features of the nestin - containing cells in brains of adult mice: a potential source of neural precursor cells 显示文摘 | Xu R Wu C Tao Y | 2010 | J Neurosci Res2010，88，5： | 1 |
| 8 | Target isolation for SAR images显示文摘 | Xu R Kwan C M Haynes L S | 2001 | Proceedings of SPIE2001，4382，： | 1 |
| 9 | Interaction of(flourescein-Trp25) glucagon with human glucagon receptor expressed in drosophila schneider 2 cells显示文摘 | TOTA M R XU L SIROTINA A STRADER C D | 1995 | J Biol Chem1995，270，26： | 1 |
| 10 | Evolution of pore fractal dimensions for burning porous chars 显示文摘 | He R Xu X C Chen C H | 1998 | Fuel1998，77，： | 1 |
| 11 | Temperature-Dependent Photoluminescence of ZnO Nanorods Prepared by a Simple Solution Route显示文摘 | Lv Y Z Zhang Y H Li C P Ren L R Guo L Xu H B Ding L Yang C L Ge W K and Yang S H | 2007 | Luminescence2007，，： | 1 |
| 12 | Hybirid methods for nonlinear least squares显示文摘 | FLETCHER R XU C | 1979 | IMAJ Numer Anal1979，7，： | 1 |
| 13 | High-level expression and stabilization of recombinant human chitinase produced in a continuous constitutive Pichia pastor/s expression system 显示文摘 | Goodrick J C Xu M Finnegan R | 2001 | Biotechnology and Bioengi- neering2001，74，6： | 1 |
| 14 | Calcium and polyamine regulated calcium-sensing receptors in cardiac tissues 显示文摘 | Wang R Xu C Zhao W | 2003 | Eur J Biochem2003，270，12： | 1 |
| 15 | Caicum and polyamine regulated calciura-sesslng receptors in card iac tissues显示文摘 | Wang R Xu C Q ZhaoW M | 2003 | Eur J Bioehem2003，270，12： | 1 |
| 16 | Erbin inhibits TGF-β1- induced EMT in renal tubular epithelial cells through an ERK-dependent pathway显示文摘 | Zhou Q Zeng R Xu C | 2012 | J Mol Med (Berl)2012，90，5： | 1 |
| 17 | Multifuncfional microbub- bles and nanobubbles for photoacoustic and ultrasound imaging显示文摘 | Kim C Qin R Xu JS | 2010 | J Biomed Opt2010，15，01： | 1 |
| 18 | Mortality among capacitor workers exposed to polychlorinated biphenyls (PCBs),a long-term update显示文摘 | KIMBROUGH R D KROUSKAS C A XU W | 2014 | International Archives of Occupational and Environmental Health2014，，： | 1 |
| 19 | 查看详情显示文摘 | Singh J Teo J H S Xu Y Premachandran C S Chen N Kotlanka R Olivo M Sheppard C J R | | 0，，： | 1 |
| 20 | Indications and detection,completion,and retention rates of small-bowel capsule endoscopy:a systematic review显示文摘 | Liao Z Gao R Xu C | | 0，，02： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员