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| 1 | Outcomes of furazolidone-and amoxicillin-based quadruple therapy for Helicobacter pylori infection and predictors of failed eradication显示文摘AIM To evaluate the outcomes of furazolidone-and amoxicillin-based quadruple therapy for treatment of Helicobacter pylori(H. pylori) infection and identify predictors of failed eradication.METHODS Patients with H. pylori infection treated with furazolidone, amoxicillin, bismuth, and proton pump inhibitor therapy(January 2015 to December 2015) who received the ^(13)C-urea breath test > 4 wk after treatment were evaluated. Demographic and clinical data including prior H. pylori treatment attempts, medication adherence, alcohol and cigarette consumption during therapy, and treatment-related adverse events were recorded by reviewing medical records and telephone surveys. H. pylori eradication rates for overall and subgroups were evaluated. Multivariate analysis was performed to identify independent predictors of failed H. pylori eradication.RESULTS Of the 992 patients treated and retested for H. pylori infection, the overall eradication rate was 94.5% [95% confidence interval(CI): 94.1%-95.9%]. H. pylori eradication rate of primary therapy was 95.0%(95%CI: 93.5%-96.5%), while that of rescue therapy was 91.3%(95%CI: 86.8%-95.8%). Among the 859 patients who completed the study protocol, 144(17%) reported treatment-related adverse events including 24(3%) leading to premature discontinuation. On multivariate analysis, poor medication adherence [adjusted odds ratio(AOR) = 6.7, 95%CI: 2.8-15.8], two or more previous H. pylori treatments(AOR = 7.4, 95%CI: 2.2-24.9), alcohol consumption during therapy(AOR = 4.4, 95%CI: 1.5-12.3), and possibly smoking during therapy(AOR = 1.9, 95%CI: 0.9-4.3) were associated with failed H. pylori eradication. CONCLUSION Furazolidone-and amoxicillin-based quadruple therapy for H. pylori infection in an area with a high prevalence of clarithromycin resistance demonstrated high eradication rates as primary and rescue therapies with a favorable safety profile. Patient education targeting abstinence from alcohol during therapy and strict medication adherence may further optimize H. pylori eradication. | Ya-Wen Zhang Wei-Ling Hu Yuan Cai Wen-Fang Zheng Qin Du John J Kim John Y Kao Ning Dai Jian-Min Si | 2018 | World Journal of Gastroenterology2018，24，40： | 18 |
| 2 | Influence of Fe Addition on Products of Self-Propagating High-Temperature Synthesis Reaction in 3Ti-Si-2C System显示文摘Influence of Fe addition on products of self-propagating high-temperature synthesis (SHS) reaction in 3Ti-Si-2C system was investigated in the present study. Without Fe addition, Ti5Si3 and TiC are the dominant phases along with a small amount of Ti3SiC2 phase and unreacted C left in the final products. As Fe content ranges from 10% to 30%, the products consist of TiC, Ti5Si3, Fe2Ti and unreacted C, but no trace of Ti3SiC2 phase is detected. Furthermore, the amounts of both Fe2Ti and C phases increase with Fe content increasing. Addition of Fe has a great effect on the reaction route and significantly restrains the formation of Ti3SiC2 during the combustion synthesis process, and therefore, the SHS is not an effective fabrication technique to synthesize the ternary Ti3SiC2 ceramic in either 3Ti-Si-2C or Fe-3Ti-Si-2C system. Besides, without Fe addition, Ti5Si3 presents as the coarse irregular appearance with an obviously sintered morphology. In contrast, the shape of Ti5Si3 exhibits more and more spherical (cobblestone-like) and the surface becomes increasingly smooth, because the amount of liquids formed during the SHS reaction increases with the increase of Fe content. On the other hand, with Fe content increasing from 0 to 30 wt.%, the particulate size of TiC decreases from more than 5 μm to 1 μm or less, mainly due to the fact that the combustion temperature decreases with the increase of Fe content in the preforms. | Guan Q L Wang H Y Li S L Si W P Jiang Q C | 2009 | 稀有金属材料与工程2009，38，A03： | 2 |
| 3 | 氨氯地平和左旋氨氯地平对高血压患者血管内皮功能的影响显示文摘已证明氨氯地平可改善高血压患者的血管内皮功能,但左旋氨氯地平是否具有类似作用仍存在争议。该研究比较氨氯地平和左旋氨氯地平对高血压患者血管内皮功能的影响,应用体外细胞培养研究其相关作用机制。方法:该研究为一项随机、交叉试验。选取原发性高血压患者24例服用氨氯地平和左旋氨氯地平各6周, | He Y Si D Yang C Ni L Li B Ding M Yang P 罗冬梅 叶鹏 | 2014 | 中华高血压杂志2014，22，4： | 2 |
| 4 | PCR - based Random Amplified Polimorophic DNA Fringerprinting of Yersinia pseudotubendosis and Its Practical Applications 显示文摘 | Makino SI Okada Y Maruyma T | 1994 | J Clin Microbiol1994，32，1： | 1 |
| 5 | Struma ovarii: CT findings显示文摘 | Jung SI Kim Y J Lee MW | 2008 | Abdom Imaging2008，33，6： | 1 |
| 6 | Fabrication of highly porous bi- odegradable monoliths strengthened by graphene oxide and their adsorption of metal ions 显示文摘 | Zhang N N Qiu H X Si Y M | 2011 | Carbon2011，49，3： | 1 |
| 7 | Adenovirus-mediated transfer of the 1-cys peroxiredoxin gene to mouse lung protects a- gainst hyperoxic injury显示文摘 | Wang Y Manevich Y Feinstein SI | 2004 | Am J Physiol Lung Cell Mol Physiol2004，286，6： | 1 |
| 8 | Large-scale analysis of KIT aberrations in Chinese patients with melanoma 显示文摘 | Kong Y Si L Zhu Y | 2011 | Clin Cancer Res2011，17，7： | 1 |
| 9 | Sorbitol dehydrogenase over-expression potentiates glucose toxicity to cultured retinal pericytes显示文摘 | Amano S Yamagishi SI Kato N Inagaku Y Okamoto T Makino M | 2002 | Bio Biophy Res Commun2002，299，2： | 1 |
| 10 | Persistence of host-specific Bacteroides-Prevotel- la 16S rRNA genetic markers in environmental waters:Effects of tem- perature and salinity显示文摘 | Okabe SI Shimazu Y | 2007 | Applied Microbiology and Biotechnology2007，76，4： | 1 |
| 11 | Combined effects of an antioxidant and caspase inhibitor on the reversal of hepatic fibrosis in rats显示文摘 | Kim do Y Chung SI Ro SW | 2013 | Apoptosis2013，18，12： | 1 |
| 12 | Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll- like receptor 4显示文摘 | Li Y Si R Feng Y | 2011 | J Biol Chem2011，286，31： | 1 |
| 13 | Synthesis of water soluble graphene 显示文摘 | Si Y Samulski E T | 2008 | Nano Lett2008，8，： | 1 |
| 14 | Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions显示文摘 | Ochs RL Muro Y Si Y | 2000 | J Allergy Clin Immunol2000，105，61： | 1 |
| 15 | Induction of allogeneic mixed chimerism by immature dendritic cells and bone marrow transplantation leads to prolonged tolerance to major histocompatibility complex disparate allografts显示文摘 | PING Y SI D X QIU Z H | 2009 | Immunology2009，127，4： | 1 |
| 16 | PhaseⅡ,open-label,single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification显示文摘 | Guo J Si L Kong Y | 2011 | J Clin Oncol2011，29，21： | 1 |
| 17 | Autophagy promotes intracellular degradation of type I collagen induced by transforminggrowth factor (TGF)-β1显示文摘 | Kim SI Na HJ Ding Y | 2012 | J Biol Chem2012，287，15： | 1 |
| 18 | Aberrations of KIT,BRAF,NRAS,and PDGFRA in Chinese melanoma patients and their significance: large scale analysis of 644 patients 显示文摘 | Kong Y Si L Guo J | 2011 | J Clin Oncol2011，29，15： | 1 |
| 19 | Controllability of Complex Networks显示文摘 | Liu Y Y Slotine J J Barabási A L | 2011 | Nature2011，473，7346： | 1 |
| 20 | Adsorption and photo-reactivity of bensulfuron-methyl on homoionic clays显示文摘 | Si Y Wang S Zhou D | 2004 | Clays & Clay Minerals2004，52，6： | 1 |
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