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| 1 | Potential role of Th17 cells in the pathogenesis of inflammatory bowel disease显示文摘The etiopathology of inflammatory bowel disease(IBD)remains elusive.Accumulating evidence suggests that the abnormality of innate and adaptive immunity responses plays an important role in intestinal inflammation.IBD including Crohn's disease(CD)and ulcerative colitis(UC)is a chronic inflammatory disease of the gastrointestinal tract,which is implicated in an inappropriate and overactive mucosal immune response to luminalflora.Traditionally,CD is regarded as a Th1-mediated inflammatory disorder while UC is regarded as a Th2-like disease.Recently,Th17 cells were identif ied as a new subset of T helper cells unrelated to Th1 or Th2 cells,and several cytokines [e.g.interleukin(IL)-21,IL-23] are involved in regulating their activation and differentiation.They not only play an important role in host defense against extracellular pathogens,but are also associated with the development of autoimmunity and inflammatory response such as IBD.The identif ication of Th17 cells helps us to explain some of the anomalies seen in the Th1/Th2 axis and has broadened our understanding of the immunopathological effects of Th17 cells in the development of IBD. | Zhan-Ju Liu Praveen K Yadav Jing-Ling Su Jun-Shan Wang Ke Fei | 2009 | World Journal of Gastroenterology2009，15，46： | 44 |
| 2 | Comparative evaluation of intragastric bile acids and hepatobiliary scintigraphy in the diagnosis of duodenogastric reflux显示文摘AIM:To assess the diagnostic value of a combination of intragastric bile acids and hepatobiliary scintigraphy in the detection of duodenogastric reflux(DGR).METHODS:The study contained 99 patients with DGR and 70 healthy volunteers who made up the control group.The diagnosis was based on the combination of several objective arguments:a long history of gastric symptoms(i.e.,nausea,epigastric pain,and/or bilious vomiting) poorly responsive to medical treatment,gastroesophageal reflux symptoms unresponsive to protonpump inhibitors,gastritis on upper gastrointestinal(GI) endoscopy and/or at histology,presence of a bilious gastric lake at > 1 upper GI endoscopy,pathologic 24-h intragastric bile monitoring with the Bilitec device.Gas-tric juice was aspirated in the GI endoscopy and total bile acid(TBA),total bilirubin(TBIL) and direct bilirubin(DBIL) were tested in the clinical laboratory.Continuous data of gastric juice were compared between each group using the independent-samples Mann-Whitney U-test and their relationship was analysed by Spearman's rank correlation test and Fisher's linear discriminant analysis.Histopathology of DGR patients and 23 patients with chronic atrophic gastritis was compared by clinical pathologists.Using the Independent-samples Mann-Whitney U-test,DGR index(DGRi) was calculated in 28 patients of DGR group and 19 persons of control group who were subjected to hepatobiliary scintigraphy.Receiver operating characteristic curve was made to determine the sensitivity and specificity of these two methods in the diagnosis of DGR.RESULTS:The group of patients with DGR showed a statistically higher prevalence of epigastric pain in comparison with control group.There was no significant difference between the histology of gastric mucosa with atrophic gastritis and duodenogastric reflux.The bile acid levels of DGR patients were significantly higher than the control values(Z:TBA:-8.916,DBIL:-3.914,TBIL:-6.197,all P < 0.001).Two of three in the DGR group have a significantly associated with each other(r:TBA/DBIL:0.362,TBA/TBIL:0.470,DBIL/TBIL:0.737,all P < 0.001).The Fisher's discriminant function is followed:Con:Y = 0.002TBA + 0.048DBIL + 0.032TBIL 0.986;Reflux:Y = 0.012TBA + 0.076DBIL + 0.089TBIL-2.614.Eighty-four point zero five percent of original grouped cases were correctly classified by this method.With respect to the DGR group,DGRi were higher than those in the control group with statistically significant differences(Z =-5.224,P < 0.001).Twenty eight patients(59.6%) were deemed to be duodenogastric reflux positive by endoscopy,as compared to 37 patients(78.7%) by hepatobiliary scintigraphy.CONCLUSION:The integrated use of intragastric bile acid examination and scintigraphy can greatly improve the sensitivity and specificity of the diagnosis of DGR. | Teng-Fei Chen Praveen K Yadav Rui-Jin Wu Wei-Hua Yu Chang-Qin Liu Hui Lin Zhan-Ju Liu | 2013 | World Journal of Gastroenterology2013，19，14： | 12 |
| 3 | Triple plating of tibia in a complex bicondylar tibial plateau fracture显示文摘高精力的胫骨的高原骨折为整形外科的外科医生提出重要挑战和困难。胫骨的高原的骨折包含主要重量适用连接并且可以改变膝 kinematics。近似胫骨的关节的表面,手足轴(手足排列) 的恢复和允许早联合的运动的稳定的固定的解剖重建是处理的目标。在胫骨的高原折断的复杂 bicondylar 的情况下,孤立侧面的 plating 经常与内翻足 malalignment 被联系,更好的结果通过双切口与双边的 plating 被获得了。然而,有时,胫骨的高原折断的 bicondylar 的一种复杂类型在中间的高原在哪个让 biplaner 象 sagittal 飞机一样在以后的花冠飞机断裂被遇到。在如此的破裂,与在两架飞机支持修理中间的高原是必要的。近似胫骨的一个如此的破裂模式通过双 posteromedial 由三倍的 plating 设法,在前面偏一边的切口在这类损害,外科的途径和管理的机制上与强调在这份情况报告被讨论。 | Atin Jaiswal Naiman Deepak Kachchhap Yashwant S Tanwar Birendra Kumar Sachin K Yadav | 2014 | Chinese Journal of Traumatology2014，17，3： | 10 |
| 4 | Lung cancer metastasis to the gastrointestinal system:An enigmatic occurrence显示文摘Adenocarcinoma of the lung infrequently metastasizes to the gastrointestinal tract. We report a rare case of a 65-year-old male with no respiratory symptoms diagnosed with adenocarcinoma of the lung by histopathological examination of metastatic sites which included an ulcer in the gastric body and a mass in the rectum. Metastatic disease also involved the liver as well. Patient was treated with systemic chemotherapy but unfortunately expired five months after the diagnosis was made. | Kanthi Rekha Badipatla Niharika Yadavalli Trupti Vakde Masooma Niazi Harish K Patel | 2017 | World Journal of Gastrointestinal Oncology2017，9，3： | 2 |
| 5 | Protection against radiation induced chromsome damage by Emblica of ficinalis fruit extract显示文摘 | Yadav S K | 1987 | Caryologia1987，40，3： | 1 |
| 6 | Livestock excreta management through vermicomposting using an epigeic earthworm Eisenia foetida 显示文摘 | GARG V K YADAV Y K SHEORAN A | 2006 | Environmentalist2006，26，： | 1 |
| 7 | Transgenic tobacco over- expressing glyoxalase pathway enzymes grow and set viable seeds in zinc- spiked soils显示文摘 | SINGLA P S L YADAV S K PAREEK A | 2006 | Plant Physiology2006，140，2： | 1 |
| 8 | Mechanism of cardiopro-tective effect of erythropoietin-induced preconditioning in ratheart显示文摘 | Garg K Yadav HN Singh M | 2010 | Indian J Pharmacol2010，42，4： | 1 |
| 9 | Tractor rid~ vibration-a review 显示文摘 | Niranjan Prasad Tewari V K Rajvir Yadav | 1995 | Journal of Terramechanics1995，32，4： | 1 |
| 10 | Host-generated double stranded RNA induces RNAi in plant-parasitic nematodes and protects the host from infection 显示文摘 | Yadav B C Veluthambi K Subramaniam K | 2006 | Molecular & Biochemical Parasitology2006，148，： | 1 |
| 11 | 显示文摘 | YADAV J S REDDY B V S REDDY K B | 2002 | Tetrahedron Lett2002，43，39： | 1 |
| 12 | Dentoskeletal and soft tis- sue effects of mini-implants in Class Ⅱ division 1 patients显示文摘 | Upadhyay M Yadav S Nagaraj K | 2009 | An- gle Orthod2009，79，2： | 1 |
| 13 | Clopidogrel resistance in North Indian patients of coronary artery disease and lack of its association with platelet ADP receptors P2YI and P2Y12 gene pol- ymorphisms显示文摘 | KAR R MEENA A YADAV B K | 2013 | Platelets2013，24，4： | 1 |
| 14 | Overexpression of a tea flavanone 3- hydroxylase gene confers tolerance to salt stress and Ahernaria solani in transgenic tobacco 显示文摘 | Mahajan M Yadav S K | 2014 | Plant Molecular Biology2014，85，6： | 1 |
| 15 | Purification and Characterization of α -L -rhamnosidase from Penicillium corylopholum MTCC - 2011 显示文摘 | Yadav S Yadava S Yadav K D S | 2013 | Process Biochemistry2013，48，9： | 1 |
| 16 | Supplier selection using fuzzy AHP and fuzzy multi-objective linear programming for developing low carbon supply chain显示文摘 | SHAW K SHANKAR R YADAV SS | 2012 | Expert Systems with Application2012，39，9： | 1 |
| 17 | Synthesis and characterizationof alginate-g-vinyl sulfonic acid with a potassium peroxydiphosphate/thiourea system显示文摘 | Sand A Yadav M Behari K | 2010 | Journal of Applied PolymerScience2010，118，6： | 1 |
| 18 | Host-generated double stranded RNA induces RNAi in plant-parasitic nematodes and protects the host from infection显示文摘 | YADAV B C VELUTHAMBI K SUBRAMANIAM K | 2006 | Mol Biochem Parasitol2006，148，2： | 1 |
| 19 | Hypolipidaemic and anti-inflammatory effects of fixed dose combination of atorvastatin plusezetimibe in Indian patients with dyslipi- daemia显示文摘 | Padhy B M Yadav R Gupta Y K | 2013 | Singapore Med J2013，54，2： | 1 |
| 20 | A clonal algorithm to solve economic load dispatch显示文摘 | Panigrahi B K Yadav S R Agrawal S | 2007 | Electric Power System Research2007，77，10： | 1 |
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