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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | 步行6min负荷超声心动图预测结缔组织病患者远期显性肺高血压显示文摘肺高血压是结缔组织病(connective tissue disease,CTD)的主要死因。运动负荷试验已用于筛查早期肺高血压[1],但由于缺乏相关证据,最新的指南已停止其作为发现肺高血压的方法。近期研究发现平均肺动脉压(mean pulmonary arterial pressure,mPAP)升高导致心输出量异常可用于评估肺高血压进展及肺功能分级[2]。该研究将步行6min后的超声心动图参数作为非侵入性负荷试验。 | Kusunose K Yamada H Hotchi J Bando M Nishio S Hirata Y Ise T Yamaguchi K Yagi S Soeki T Wakatsuki T Kishi J Sata M 曲浥晨 | 2015 | 中华高血压杂志2015，23，10： | 3 |
| 3 | Adaptive Attitude Control for an Artificial Satellite with Mobile Bodies显示文摘 | Yamada K Yoshikawa S J | 1996 | Journal of Guidance Control and Dynamics1996，19，4： | 2 |
| 4 | Prognostic value of cyclin E and p53 expression in gastric carcinoma显示文摘 | Sakaguchi T Watanabe A SawadaH Yamada Y Yamashita J Matsuda M Nakajima M Miwa T Hirao T Nakano H | | 0，，： | 2 |
| 5 | Feasibility of magnetic liposomes as a targeting device for drug 显示文摘 | Kiwada H Sato J Yamada S | 1986 | Chem Pharm Bull1986，34，： | 1 |
| 6 | Five-year outcome of intraoperative conformal permanent 1-125 interstitial implantation for patients with clinically localized prostate cancer显示文摘 | Zelefsky M J Yamada Y | 2007 | Int J Radiat Oncol Biol Phys2007，67，1： | 1 |
| 7 | Prostaglandin E2 receptors EP2 and EP4 are up-regulated in peritoneal macrophages and joints of pristane-treated mice and modulate TNF-alpha and IL-6 production显示文摘 | Yamada H Kuroda Y | 2004 | J Leukoc Biol2004，76，1： | 1 |
| 8 | Comparison of ecotourism policies and implications for China's ecotourism development 显示文摘 | Wang S Heo J Yamada N Hwang S T | 2009 | Journal of China Tourism Research2009，5，3： | 1 |
| 9 | Cellular sensitization to cisplatin and carboplatin with decreased removal of platinum-DNA adduct by glucose-regulated stress显示文摘 | YAMADA M TOMIDA A YUN J | 1999 | Cancer Chemother Pharmacol1999，44，1： | 1 |
| 10 | Predictors of progression from prehypertension to hypertension in Japanese men 显示文摘 | Tomiyama H Matsumoto C Yamada J | 2009 | Am J Hypertens2009，22，11： | 1 |
| 11 | Fabrication of three-dimensional network of ZnO tetratpods and its response to ethanol显示文摘 | Delaunay J Kakoiyama N Yamada I | 2007 | Mater Chem Phys2007，104，1： | 1 |
| 12 | Tumor suppressor PTEN inhibits inte- grin- and growth factor-mediated mitogen-activated protein (MAP) ki- nase signaling pathways 显示文摘 | Gu J Tamura M Yamada K M | 1998 | J Cell Biol1998，143，5： | 1 |
| 13 | Detection of influenza virus in throat swab by using polymerase chain reaction显示文摘 | Yamada A Imanishi J Nakajima E | 1991 | Microbiol Immunlol1991，35，3： | 1 |
| 14 | 显示文摘 | Yamada J Zhu SN Streilein JW | 2000 | Invest Ophthalmol Vis Sci2000，41，13： | 1 |
| 15 | The use of frozen autogenous bone flaps in delayed cranioplasty revisited显示文摘 | Iwama T Yamada J Imai S | 2003 | Neurosurgery2003，52，3： | 1 |
| 16 | Alterations in cardiac tissue of paitient with chronic atrial fibrillation 显示文摘 | Ohkusa T Ueyama T Yamada J | 2000 | Circulation2000，101，： | 1 |
| 17 | Alterations in cardiac sarcoplasmic reticulum Caz+ regulatory proteins in the atrial tissue of patients with chronic atrial fibrillation显示文摘 | Ohkusa T Ueyama T Yamada J | 1999 | J Am Coil Cardiol1999，34，1： | 1 |
| 18 | Identification of a 428-kb homozygously deleted region disrupting the SEZ6L gene at 22q12.1 in alung cancer cell line显示文摘 | Nishioka M Kohno T Takahashi M Niki T Yamada T Sone S Yokota J | | 0，，： | 1 |
| 19 | Effect of agglomera- tion of Pt/C catalyst on hydrogen peroxide formation 显示文摘 | Inaba M Yamada H Tokunaga J | 2004 | Electrochem Solid-State Left2004，7，： | 1 |
| 20 | Interferongamma production by neutrophils during bacterial pneumonia in mice显示文摘 | Yamada M Gomez J C Chugh P E | 2011 | Am J Respir Crit Care Med2011，183，10： | 1 |
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