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| 1 | Proton magnetic resonance spectroscopy of normal human brain and glioma: a quantitive in vivo study显示文摘Background In vivo proton magnetic resonance spectroscopy (MRS) provides a noninvasive method of examining a wide variety of cerebral metabolites in both healthy subjects and patients with various brain diseases. Absolute metabolite concentrations have been determined using external and internal standards with known concentrations. When an external standard is placed beside the head, variations in signal amplitudes due to B1 field inhomogeneity and static field inhomogeneity may occur. Hence an internal standard is preferable. The purpose of this study was to quantitatively analyze the metabolite concentrations in normal adult brains and gliomas by in vivo proton MRS using the fully relaxed water signal as an internal standard.Methods Between January 1998 and October 2001, 28 healthy volunteers and 16 patients with gliomas were examined by in vivo proton MRS. Single-voxel spectra were acquired using the point-resolved spectroscopic pulse sequence with a 1.5 T scanner (TR/TE/Ave=3000 ms/30 ms/64).Results The calculated concentrations of N-acetyl-asparatate (NAA), creatine (Cre), choline (Cho), and water (H2O) in the normal hemispheric white matter were (23.59±2.62) mmol/L, (13.06±1.8) mmol/L, (4.28±0.8) mmol/L, and (47280.96±5414.85) mmol/L, respectively. The metabolite concentrations were not necessarily uniform in different parts of the brain. The concentrations of NAA and Cre decreased in all gliomas ( P <0.001). The ratios of NAA/Cho and NAA/H2O showed a significant difference between the normal brain and gliomas, and also between the high and low grades ( P <0.001).Conclusions Quantitative analysis of in vivo proton MR spectra using the fully relaxed water signal as an internal standard is useful. The concentrations of NAA and the ratios of NAA/H2O and NAA/Cho conduce to discriminating between the glioma and normal brain, and also between the low-grade glioma and high-grade glioma. | TONG Zhi-yong YAMAKI Toshiaki WANG Yun-jie | 2005 | Chinese Medical Journal2005，，15： | 15 |
| 2 | 使用ATP酶敏感钾离子通道开放剂——尼可地尔静脉给药用于冠状动脉腔内血管成形术介入治疗的药学证据显示文摘1前言动物实验研究表明,反复短暂的冠脉闭塞导致心脏抗心肌缺血的发作,这种现象被称为缺血性预处理。一些研究表明,这种预处理的效果是由于ATP敏感性钾通道的激活(KATP通道)。人类涉及经皮冠状动脉成形术(PTCA)的临床研究发现KATP通道的关闭与格列本脲防止预处理的效果通常出现在反复球囊扩张期间血管成形术模型中,表明ATP敏感性钾通道在预处理中发挥了核心作用。 | Hitoshi Matsuo Sachiro Watanabe Tomonori Segawa Shinji Yasuda Takeshi Hirose Makoto Iwama Shinichiro Tanaka Takahiko Yamaki Yukihiko Matsuno Masaaki Tomita Shinya Minatoguchi Hisayoshi Fujiwara 魏丽莎 | 2015 | 首都食品与医药2015，0，8： | 3 |
| 3 | Analysis of electronic structures of 3d transition metal-doped TiO 2 based on band calculations显示文摘 | Tsutomu Umebayashi Tetsuya Yamaki Hisayoshi Itoh Keisuke Asai | 2002 | Journal of Physics and Chemistry of Solids2002，，10： | 2 |
| 4 | Construction of on-line supercritical fluid extraction with reverse phase liquid chromatography–tandem mass spectrometry for the determination of capsaicin显示文摘A novel on-line system composed of supercritical fluid extraction(SFE), dilution line and reverse phase liquid chromatography/mass spectrometry(RPLC/MS) was constructed for on-line extraction and reverse phase separation of some fat-soluble components in foods. Three columns including a trap column,concentration column and analytical column were used for trapping the fat-soluble components, on-line enrichment and reverse phase separation, respectively. Capsaicinoids were on-line extracted by a CO_2 supercritical fluid, then concentrated and separated by using the C_(18) columns, finally detected by mass spectrometry(MS). Capsaicin eluted at 10.1 min and limit of detection(LOD, S/N=3) for the standard solution is 0.55pg. The linearity was calculated with a value of coefficient of determination(R^2)≥0.998 in the range of 1.1–8.5 ng. Concentrations of capsaicin in the green, yellow, and red bell peppers were determined to be 60.33 ng/g, 31.79 ng/g, 35.38ng/g, respectively. | Naoki Hamada Yuki Hashi Satoshi Yamaki Yanli Guo Lin Zhang Haifang Li Jin-Ming Lin | 2019 | Chinese Chemical Letters2019，30，1： | 2 |
| 5 | Change in sugar content and sorbitol - and sucrose - related enzyme activities during development of loquat fruit 显示文摘 | Bantog N A Shiratake K Yamaki S | 1999 | Journal Japanese Society Horticulture Science1999，68，5： | 1 |
| 6 | Proliferative fasciitis of the forearm:Case report with immunohistochemical,ultrastructural and DNA ploidy studies and review of the literature显示文摘 | Sasano H Yamaki H Ohashi Y | 1998 | Pathology international1998，48，： | 1 |
| 7 | 显示文摘 | Yamaki J I Tobishima S I Hayashi K | 1998 | J Power Sources1998，74，： | 1 |
| 8 | A polyphenol and two bibenzyls from Pleione bulbocodioides 显示文摘 | Bai L Maxukawa N Yamaki M | 1997 | Phytochemistry1997，47，8： | 1 |
| 9 | Characteristics of histamine-induced leukocyte rolling in the undisturbed mi-crocirculation of the rat mesentery显示文摘 | Yamaki K Thorlacius H Xie X | 1998 | Br J Pharmacol1998，123，3： | 1 |
| 10 | Band gap narrowing of titanium dioxide by sulfur doping显示文摘 | Umebayashi T Yamaki T hoh H | 2002 | Ap- plied Physics Letters2002，81，3： | 1 |
| 11 | Cloning and sequencing of a nitrile hydratase gene from Pseudonocardia thermophila JCM3095显示文摘 | Toshifumi Yamaki Toshihiro Oikamw Kiyoshi Ito | 1997 | Journal of Fermentation and Bioengineering1997，83，： | 1 |
| 12 | Levels and role of sucrose synthase accumulation in fruit of Asian pear显示文摘 | MORIGUCHI T ABE K YAMAKI S | 1992 | J Amer Soc Hort Sci1992，117，2： | 1 |
| 13 | Aromatization of androstenedione by normal and neoplastic endometrium of the uterus显示文摘 | Yamamoto T Okada H | 1985 | J Steroid Biochem1985，22，： | 1 |
| 14 | Pathological study of difuse axonal injury patients who died shortly after impact 显示文摘 | Yamaki T Murakami N Lwamoto Y | 1992 | Acat Neurochir1992，119，1： | 1 |
| 15 | Patterns of venous insufficiency after an acute deep vein thrombosis显示文摘 | Yamaki T Nozaki M | 2005 | J Am Coil Surg2005，201，2： | 1 |
| 16 | Traumatic acute subdural hematoma localized on the superior surface of the tentorium cerebelli-two case reports显示文摘 | Matsurnoto K Houri T Yamaki T | 1996 | Neurol Med Chir Tokyo1996，36，6： | 1 |
| 17 | Purification and characterization of sucrose synthase from peach fruit显示文摘 | Moriguchi T Yamaki S | 1988 | Plant Cell Physiol1988，29，8： | 1 |
| 18 | Anti-a-glucosidase activity of Chinese traditionally fermented soybean(douchi)显示文摘 | Jing C Cheng YQ Yamaki K | 2007 | Food chemistry2007，103，4： | 1 |
| 19 | Four stilbenoids from Pleione bulbocodioides 显示文摘 | Bai L Maxukawa N Yamaki M | 1998 | Phytochemistry1998，48，2： | 1 |
| 20 | Tyrosinase family proteins are antigens specific to Vogt-Koyanagi-Harada disease显示文摘 | Yamaki K Gocho K Hayakawa K | 2000 | J Immunol2000，16，5： | 1 |
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