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| 1 | 1990—2017年中国伤害负担:2017年全球疾病负担研究结果(摘译)显示文摘伤害是全球性的公共卫生挑战,涉及各年龄组和不同性别的人群。过去三十年来,中国经济快速发展,人口老龄化趋势加重,社会呈现出城镇化、机动化和老龄化等特征。随着人们生活环境和生活方式的改变,伤害已跃居人群致死原因第五位,仅排在恶性肿瘤、心脑血管疾病、呼吸系统疾病和心肌梗死之后。据估计,中国每年在伤害方面消耗的直接医疗费用约为650亿元人民币. | 林泽婷(译) 吕来文(译) 黄晓晴(译) 李丽萍(审校) Duan Leilei Ye Pengpeng Juanita A Haagsma Jin Ye Wang Yuan Er Yuliang Deng Xiao Gao Xin Ji Cuirong Wang Linhong Marlena S Bannick W Cli Mountjoy-Venning Caitlin N Hawley Zichen Liu Mari Smith Spencer L James Theo Vos Christopher J L Murray | 2020 | 伤害医学(电子版)2020，9，2： | 15 |
| 2 | 桑叶多糖对早期断奶仔猪生长性能、腹泻、血液指标和肠道菌群的影响显示文摘研究旨在探讨日粮补充桑叶多糖(MLPs)对早期断奶仔猪生长性能、腹泻、血液生化指标和肠道菌群的影响。共选取(28±2)日龄、体重为(9.18±0.46)kg的'杜洛克×长白×约克夏'杂交断奶仔猪150头,随机分成5个处理组,每组6个重复,每个重复5头猪。饮食处理如下:对照组(CT):基础日粮(BD);低剂量桑叶多糖组(LT):0.3 g·kg-1MLPs+BD;中剂量桑叶多糖组(MT):0.6 g·kg-1MLPs+BD;高剂量桑叶多糖组(HT):0.9 g·kg-1MLPs+BD;抗生素处理组(AT):0.15 g·kg-1金霉素+BD。分别在第0、10、21天的早晨,每头猪空腹测量体重并记录采食量,这些数据用来计算平均日增重(ADG)、平均日采食量(ADFI)和料重比(F/G)。每天两次(上午和下午)对每头仔猪的腹泻状况进行检查并记录。在试验结束时,收集血液样本用于生化分析,并收集盲肠、结肠和直肠内容物进行识别和量化相关的肠道菌群。研究结果表明,MLPs处理组间的日增重、平均日采食量和料重比无显著差异(P>0.05),但低剂量组(LT)、中剂量组(MT)、高剂量组(HT)的平均日采食量高于对照组(CT)和抗生素组(AT)。并且,LT、MT和HT组的料重比低于CT和AT组。与CT和AT组相比,LT、MT和HT组仔猪的腹泻发病率也显著降低(P<0.05)。生化分析表明,MLPs各处理组仔猪的血糖(GLU)水平均显著低于CT或AT组(P<0.05)。MT和HT组血液尿素氮(BUN)水平与CT和AT组存在显著差异(P<0.05),HT组T3水平显著高于CT和AT组(P<0.05)。虽然MLPs各处理组的T4水平与AT组并没有显著差异(P>0.05),但MT组的胰岛素样生长因子Ⅰ(IGF-Ⅰ)和生长激素(GH)水平较CT或AT组均显著升高(P<0.05)。LT、MT和HT 3组在抑制肠道大肠杆菌生长和促进肠道乳酸杆菌和双歧杆菌生长的整体效果上均优于CT和AT组。值得注意的是,与CT和AT组相比,HT组(0.9 g·kg-1MLPs)对抑制肠道大肠杆菌以及促进肠道有益菌群具有更显著效果(P<0.05)。结果表明,日粮添加桑叶多糖可以改善早期断奶仔猪肠道菌群的生态环境,降低腹泻率,提高整体生长性能。 | Zhao X J Lin L Luo Q L Ye M Q Luo G Q Kuang Z S | 2015 | 饲料博览2015，0，7： | 7 |
| 3 | VEGF-specific siRNAs modified with 2′-deoxy effectively suppress VEGF expression and inhibit growth of nasopharyngeal carcinoma xenograft in a mouse model显示文摘Vascular endothelial growth factor (VEGF) is up-regulated in the vast majority of human tumors. The up-regulation of VEGF not only plays important roles in tumor angiogenesis, but also provides a target for tumor treatment with small interfering RNA (siRNA) that targets VEGF; however, it is unclear whether a quite high up-regulation of VEGF will affect the efficiency of RNA interference strategies targeting VEGF. A high level expression of VEGF was found in CNE cells from a nasopharyngeal carcinoma cell line. In this study, we investigate whether VEGF-specific siRNAs can effectively suppress VEGF expression in CNE cells, and study the methods for the use of VEGF-specific siRNAs as potential therapeutic agents. CNE cells with high VEGF expression induced by hypoxia were transfected with VEGF-specific siRNAs. The expression of VEGF was effectively suppressed by VEGF-specific siRNAs, measured by ELISA, Western blot analysis and RT-PCR. Furthermore, experiments in nude mice bearing nasopharyngeal carcinoma xenograft were initiated 5 d after injection of CNE cells. VEGF-specific siRNAs were modified with 2′-deoxy, then injected into the tumors, and a liposome-mediated siRNA transfection system and ultrasound exposure were used to help delivery of the siRNAs. Tumor growth was reduced significantly after 3 weeks' treatment. These studies suggest that VEGF-specific siRNAs still can effectively suppress VEGF expression even in tumor cell lines with a relatively high level of VEGF expression, such as CNE, and VEGF-specific siRNAs modified with 2′-deoxy can be used as potential agents for tumor therapy. | CHEN ShanYi1, GAO GuoFeng1, CHEN Wei1, Lü Qing2, TANG Shen2, HUA Zhong2, YE WenBin2, GU DaYong2, WANG ShaYan1 & ZHANG YaOu2 1 Shenzhen People’s Hospital, Clinical Medical College of Jinan University, Shenzhen 518020, China 2 Life Science Division, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China | 2008 | Science China(Life Sciences)2008，51，2： | 6 |
| 4 | Flavonoids and volatiles in Chrysanthe-mum morifolium Ramat flower from Tongxiang county in China显示文摘 | SUN Q L HUA S YE J H | 2010 | AfricanJ Biotech2010，9，25： | 1 |
| 5 | Maximum seismic energy in stru- tures 显示文摘 | Ye L P Otani S | 1999 | Earthquake Engineering and Structural Dy- namics1999，28，： | 1 |
| 6 | Bone morphogenetic pro- tein-10 (BMP-10) inhibits aggressiveness of breast cancer cells and correlates with poor prognosis in breast cancer显示文摘 | Ye L Bokobza S Li J | 2010 | Cancer Sci2010，101，： | 1 |
| 7 | Effects of conjugated lino- leic acid on color and lipid oxidation of beef patties during cold storage显示文摘 | HUR S J YE B W LEE J L | 2004 | Meat Science2004，66，： | 1 |
| 8 | Solvent-induced self-assembly of polymer-tethered nanorods显示文摘 | He L L Zhang L X Ye Y S | 2010 | J Phys Chem2010，114，： | 1 |
| 9 | Comparative cytogenetic studies on the red muntjac, Chinese muntjac and their F1 hybrids显示文摘 | SHI L M Ye Y Y DUAN X S | 1980 | Cytogenetics and Cell Genetics1980，26，： | 1 |
| 10 | The effect of concession period design on completion risk management of BOT projects显示文摘 | Ye S D Tiong R L K | 2003 | Construction Management and Economics2003，21，： | 1 |
| 11 | Shear strength of reinforced concrete columns strengthened with carbon-fiber-reinforced plastic sheet 显示文摘 | YE L P YUE Q R ZHAO S H | 2002 | Journal of Structural Engineering ASCE2002，128，12： | 1 |
| 12 | A new fuel cell electrocatalyst based on highly porous carbonized polyacrylonitrile foam with very low platinum loading 显示文摘 | Ye S Vijh A K Dao L H | 1996 | Journal of the Electrochemical Society1996，143，1： | 1 |
| 13 | Extremely high prevalence of neural tube defects in a 4 - county area in Shanxi Province, China 显示文摘 | Li Z Ren A Zhang L Ye R Li S Zheng J Hong S Wang T Li Z | 2006 | Birth Defects Res A Clin Mol Teratol2006，76，4： | 1 |
| 14 | Perceiving multiple affordances for objects显示文摘 | YE Lin CARDWELL W MARK L S | 2009 | Ecological Psychology2009，21，3： | 1 |
| 15 | Sperm movement during double fertilization of a flowering plant,Phaius tankervilliae显示文摘 | Ye X L Yeung E C Zee S Y | | 0，，： | 1 |
| 16 | Fault diagnosis of plunger pump in truck crane based on relevance vector machine with particle swarm optimization algorithm 显示文摘 | Du W L Li A S Ye P F | 2013 | Shock and Vibration2013，20，4： | 1 |
| 17 | Phytoremediation ofatsenic contaminated paddy soil with Pteris vittata markedly reduces arsenic uptake by rice显示文摘 | Ye W L Khan M A McGrath S T | 2011 | Environmental Pollution2011，159，： | 1 |
| 18 | Paclitaxel inhibits ovarian tumor growth by inducing epithelial cancer cells to benign fibroblast-like cells 显示文摘 | Jia L Zhang S Ye Y | 2012 | Cancer Lett2012，326，2： | 1 |
| 19 | Maximum Seismic Displacement of Inelastic Systems Based on Energy Concept显示文摘 | Otani S | 1999 | Earthquake Engineering and structural Dynamics1999，28，： | 1 |
| 20 | Effect of polysaccharides from Angelica sinensis on gastric ulcer healing 显示文摘 | Ye Y N So H L Liu E S L | 2003 | Life Sciences2003，72，： | 1 |
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