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| 1 | 基于Pareto熵的多目标粒子群优化算法显示文摘粒子群优化算法因形式简洁、收敛快速和参数调节机制灵活等优点,同时一次运行可得到多个解,且能逼近非凸或不连续的Pareto最优前端,因而被认为是求解多目标优化问题最具潜力的方法之一.但当粒子群优化算法从单目标问题扩展到多目标问题时,Pareto最优解集的存储与维护、全局和个体最优解的选择以及开发与开采的平衡等问题亦随之出现.通过目标空间变换方法,采用Pareto前端在被称为平行格坐标系统的新目标空间中的分布熵及差熵评估种群的多样性及进化状态,并以此为反馈信息来设计进化策略,使得算法能够兼顾近似Pareto前端的收敛性和多样性.同时,引入格占优和格距离密度的概念来评估Pareto最优解的个体环境适应度,以此建立外部档案更新方法和全局最优解选择机制,最终形成了基于Pareto熵的多目标粒子群优化算法.实验结果表明:在IGD性能指标上,与另外8种对等算法相比,该算法在由ZDT和DTLZ系列组成的12个多目标测试问题集中表现出了显著的性能优势. | 胡旺 Gary G. YEN 张鑫 | 2014 | 软件学报2014，25，5： | 134 |
| 2 | Molecular therapy for hepatic injury and fibrosis:Where are we?显示文摘肝的纤维变性是弯屈的愈合的回答,包含发炎和纤维发生的小径。响应各种各样的侮辱,例如酒精,局部缺血,病毒的代理人,和药或肝毒素, hepatocyte 损坏将在肝由 Kupffer 房间和另外的房间类型引起 cytokines 和另外的可溶的因素的版本。这些因素导致肝的星形细胞的激活,它综合大量细胞外的矩阵部件。与长期的损害和纤维变性,肝建筑学和新陈代谢被破坏,最后作为肝硬化和它的复杂并发症表明。除了消除病原学,例如抗病毒的治疗和药理学干预,新奇策略正在被开发直接在细胞的潜水艇和分子的层次探讨肝的损害和纤维变性,这令人鼓舞。与在理解这些机制和小径的改进,在损害给步调音,发信号,激活,和基因表示被分子的形式和分子的其它或基因治疗途径正在指向。这篇文章打算为肝的损害和纤维变性以分子的治疗的当前的地位提供更改并且我们多远从这些新治疗学的形式的临床的利用。 | Colette C Prosser Roy D Yen Jan Wu | 2006 | World Journal of Gastroenterology2006，12，4： | 41 |
| 3 | Thalidomide-based multidisciplinary treatment for patients with advanced hepatocellular carcinoma:A retrospective analysis显示文摘AIM:To evaluate the efficacy of thalidomide in combination with other therapies to treat patients with advanced hepatocellular carcinoma (HCC).METHODS:We performed a retrospective analysis of all patients with HCC who were treated with thalidomide for at least two months.The medical records of patients with HCC who were treated at our institution between April 2003 and March 2008 were reviewed.Image studies performed before and after treatment,tumor response,overall survival,and the decrease in α-fetoprotein (AFP) levels were evaluated.RESULTS:A total of 53 patients with HCC received either 100 or 200 mg/d of thalidomide.The patient population consisted of 9 women and 44 men with a median age of 61 years.Thirty patients (56.6%) were classified as Child-Pugh A,and 12 patients (22.6%) were classified as Child-Pugh B.Twenty-six patients had portal vein thrombosis (49.1%),and 25 patients had extrahepatic metastasis (47.1%).The median duration of thalidomide treatment was 6.0 mo.Six of the 53 patients achieved a confirmed response (11.3%),one achieved a complete response (1.9%) and 5 achieved a partial response (9.4%).The disease control rate (CR + PR + SD) was 28.3% (95% CI:17.8-42.4),and the median overall survival rate was 10.5 mo.The 1-and 2-year survival rates were 45% and 20%,respectively.Only one complete response patient showed an improved overall survival rate of 66.8 mo.Sixteen patients (30.2%) showed more than a 50% decrease in their serum AFP levels from baseline,indicating a better response rate (31.3%),disease control rate (43.8%),and overall survival time (20.7 mo).The therapy was well tolerated,and no significant toxicities were observed.CONCLUSION:Thalidomide was found to be safe for advanced HCC patients,demonstrating anti-tumor activity including response,survival,and AFP decreases of greater than 50% from baseline. | Yang-Yuan Chen Hsu-Heng Yen Kun-Ching Chou Shun-Sheng Wu | 2012 | World Journal of Gastroenterology2012，18，5： | 25 |
| 4 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis显示文摘 | Huang Norden E. Shen Zheng Long Steven R. Wu Manli C. Shih Hsing H. Zheng Quanan Yen Nai-Chyuan Tung Chi Chao Liu Henry H | 1998 | Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences . 1998 (1971)1998，，1971： | 22 |
| 5 | 3D printing of bone tissue engineering scaffolds显示文摘Tissue engineering is promising in realizing successful treatments of human body tissue loss that current methods cannot treat well or achieve satisfactory clinical outcomes.In scaffold-based bone tissue engineering,a high performance scaffold underpins the success of a bone tissue engineering strategy and a major direction in the field is to produce bone tissue engineering scaffolds with desirable shape,structural,physical,chemical and biological features for enhanced biological performance and for regenerating complex bone tissues.Three-dimensional(3D)printing can produce customized scaffolds that are highly desirable for bone tissue engineering.The enormous interest in 3D printing and 3D printed objects by the science,engineering and medical communities has led to various developments of the 3D printing technology and wide investigations of 3D printed products in many industries,including biomedical engineering,over the past decade.It is now possible to create novel bone tissue engineering scaffolds with customized shape,architecture,favorable macro-micro structure,wettability,mechanical strength and cellular responses.This article provides a concise review of recent advances in the R&D of 3D printing of bone tissue engineering scaffolds.It also presents our philosophy and research in the designing and fabrication of bone tissue engineering scaffolds through 3D printing. | Chong Wang Wei Huang Yu Zhou Libing He Zhi He Ziling Chen Xiao He Shuo Tian Jiaming Liao Bingheng Lu Yen Wei Min Wang | 2020 | Bioactive Materials2020，5，1： | 20 |
| 6 | 公立医院管理与考核的国际经验及启示显示文摘本文考察了英国、澳大利亚、美国和WHO在欧洲推荐的公立医院管理和考核评估制度的情况,从重视管理与考核在公立医院改革中不可替代的地位、建立集中统一的公立医院管理机构、正确处理'管医院'和'办医院'的关系、正确处理考核监督和医院自主权的关系、建立层层问责的责任体系、建立完善的考核机构、考核指标和考核制度等方面,讨论了各国公立医院管理与考核的经验和结论,并提出完善我国公立医院管理、特别是考核评估的政策建议,包括明确公立医院考核评估机构、建立完善的考核评估制度、在充分调研和征求意见的基础上,构造科学的公益性考核指标等。 | 李玲 张维 江宇 李明强 Michael Yen 丁耀武 | 2010 | 中国卫生政策研究2010，3，5： | 20 |
| 7 | Insulin resistance is associated with hepatocellular carcinoma in chronic hepatitis C infection显示文摘AIM:To elucidate the role of insulin resistance(IR) and serum adiponectin level in hepatocellular carcinoma(HCC) associated with chronic hepatitis C.METHODS:Clinical and biochemical characteristics were collected from 165 consecutive patients with newly diagnosed HCC.Homeostasis model assessment of IR(HOMA-IR) and serum adiponectin level were investigated in 188 patients with different stages of hepatitis C virus(HCV) infection.RESULTS:Among HCC patients,type 2 diabetics(DM) was more prevalent in HCV subjects(35.6%,n = 59) compared to hepatitis B virus(HBV;12.7%,n = 63) or non-HBV,non-HCV cases(7.1%,n = 28).In patients with chronic hepatitis C,HCC subjects had higher blood sugar(P < 0.001),insulin level(P = 0.003) and HOMAIR(P = 0.018) than those with chronic hepatitis and advanced fibrosis.Age,male sex and body mass index were significantly associated with serum adiponectin level,whereas HOMA-IR was not.Based on stepwise logistic regression analysis,age(OR:1.124,P < 0.001),serum insulin level(OR:1.585,P < 0.001),HOMA-IR(OR:0.495,P = 0.001),DM(OR:11.601,P = 0.002) and male sex(OR:3.877,P = 0.016) were independently associated with HCC.This result was similar even if the diabetic subjects were excluded for analysis.CONCLUSION:Insulin resistance measured by HOMAIR,regardless of the presence of diabetes,is significantly associated with HCC development in patients with chronic HCV infection. | Chao-Hung Hung Jing-Houng Wang Tsung-Hui Hu Chien-Hung Chen Kuo-Chin Chang Yi-Hao Yen YuanHung Kuo Ming-Chao Tsai Chuan-Mo Lee | 2010 | World Journal of Gastroenterology2010，16，18： | 18 |
| 8 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis显示文摘 | Huang Norden E. Shen Zheng Long Steven R. Wu Manli C. Shih Hsing H. Zheng Quanan Yen Nai-Chyuan Tung Chi Chao Liu Henry H | 1998 | 1998 (1971)1998，，1971： | 18 |
| 9 | Cenozoic stratigraphy of Taiwan:Window into rifting,stratigraphy and paleoceanography of South China Sea显示文摘Shallow marine sequences of the northern South China Sea (SCS) are uplifted and exposed by plate convergence in the Taiwan mountain belt. These deposits provide detailed geological information about the rifting event, stratigraphy, sedimentology, paleoclimate and paleoceanography of the shallow SCS to compare with what are recorded in the ODP 1148 deep-sea core. Seismic surveys and marine micropalentological studies show that Eocene sequences in the offshore Taiwan Strait and onland Taiwan mountain belt are all deposited in rifting basins and are covered unconformably by the Late Oligocene-Neogene post-rifting strata. Between syn-rifting and post-rifting sequences, there is a regional break-up unconformity throughout the island. Early Oligocene and Late Eocene strata are missing along the break-up unconformity equivalent to the T7 unconformity in the Pearl River Mouth Basin off south China. This may suggest that the SCS oceanic crust could have initiated between 33 and 39 Ma. Neither obvious stratigraphic gap nor slumping features are found in the Oligocene-Miocene transition interval of Taiwan. This observation highly contrasts with what has been documented from the ODP 1148 deep-sea core. This suggests that the stratigraphic gap and slumping features could only be recorded in the SCS deep sea region, but not in the shallow shelf near Taiwan. Compared to the Middle Miocene paleoceanographic re-organization events in the SCS deep sea, the geological history of the Taiwan shallow sequence shows changes of in sedimentation and faunal composition. Due to the Antarctic glacial expansion at^14 Ma, Middle to late Miocene strata of the Western Foothills show progressive regression sedimentations associated with a decrease of benthic foraminif-eral abundance and a sharp faunal turnover event. Many Early-Middle Miocene endemic benthic foraminifers were extinct in 14-13 Ma and new benthic foraminifers of the Kuroshio Current fauna appeared from 10.2 Ma, comparable with new occurrence of Modern benthic foraminifers at 9 Ma in the Java Sea area. This reveals that the Western Boundary Kuroshio Current in the North Pacific could initiate from 10-9 Ma due to closures of the Indo-Pacific seaways by convergent tectonics between the Australian Continent and the Indonesian Arc in 12-8 Ma. Subduction of the SCS oceanic lithosphere since the Middle Miocene resulted in formation of the Hengchun Ridge accretionary prism and the North Luzon Arc. Occurrence of these two bathymetric highs ( 2400 m) since the Middle Miocene and closures of the inter-arc passages in the North Luzon arc in the last 3.5 Ma would control the water exchanges between the West Pacific and the deep SCS. Accordingly, the tectonic evolution in the Central Range-Hengchun Peninsula accretionary prism and the arc-forearc Coastal Range not only control directly the route for water exchanges between the West Pacific and the SCS, but also indirectly shows a great influence on the geochemistry of deep SCS waters. The latter is best shown by much negative carbon isotope values of benthic foraminifers in the ODP 1148 deep-sea core than the West Pacific records in the last 14 Ma. | HUANG Chi-Yue YEN Yi ZHAO QuanHong LIN Chiou-Ting | 2012 | Chinese Science Bulletin2012，57，24： | 16 |
| 10 | Monosodium urate crystals trigger Nrf2- and heme oxygenase-1-dependent inflammation in THP-1 cells显示文摘痛风的关节炎是被 monosodium urate (MSU ) 的累积在关节引起晶体的煽动性的疾病。MSU 能够激活核苷酸绑定 oligomerization 包含 3 的像域的受体 pyrin 领域(NLRP3 ) inflammasome,导致 interleukin-1β(IL-1β) 分泌物。反应的氧种类(ROS ) 是 NLRP3/IL-1β 的主要调停人;相互作用。尽管原子因素 E2 相关的因素(Nrf2 ) 2 作为一个抄写因素被认出涉及对氧化应力的反应, Nrf2 上并且在调停 Nrf2 的抗氧化剂酶上的 MSU 的效果仍然保持不清楚。用 phorbol 12 十四酸盐 13 醋酸盐(PMA ) 的 THP-1 单核白血球的处理被显示开始煽动性的回答。这里,我们显示出那 THP-1 房间,有 MSU 晶体的后面的处理,显著地增加的 IL-1β版本, NLRP3 inflammasome 激活和 ROS 生产。MSU 也支持了 Nrf2 的原子 translocation 并且激活 lysosomal destabilization。而且,在基因和蛋白质表情的 heme oxygenase-1 (HO-1 ) 的层次是由 MSU 的 upregulated。导致 MSU 的 IL-1β分泌物和 NLRP3 inflammasome 激活被禁止由 Nrf2 并且经由 HO-1 禁止者锌(II ) 击倒 protoporphyrin IX (ZnPP ) 。另外, HO-1 抑制增加了 superoxide 阴离子生产和谷胱甘肽的消费的水平。这些调查结果建议 Nrf2 和 HO-1 调停氧化还原作用动态平衡并且在质问 MSU 的 THP-1 房间与支持 inflammatory 因素交往,从而提供导致 MSU 的痛风的发炎怎么被涉及 Nrf2/Ho-1 的特定的机制调停的新卓见抗氧化剂发信号小径。 | Jhih-Jia Jhang Yu-Ting Cheng Cheng-Ying Ho Gow-Chin Yen | 2015 | Cellular & Molecular Immunology2015，12，4： | 15 |
| 11 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis显示文摘 | Huang Norden E. Shen Zheng Long Steven R. Wu Manli C. Shih Hsing H. Zheng Quanan Yen Nai-Chyuan Tung Chi Chao Liu Henry H | 1998 | Proceedings of the Royal Society A: Mathematical Physical and Engineering Sciences1998，，1971： | 15 |
| 12 | 猪体内微生物对纤维利用的研究进展显示文摘日粮纤维素可满足生长猪维持能量需要的30%,母猪从日粮纤维摄入的能量越高,母猪的繁殖性能及健康状况越好。谷物饲料和高质量蛋白质供给充足,必然限制纤维饲料的使用,然而随着人类对谷物粮食需求的增加,养猪业,特别是种猪生产者,不得不用其它饲料代替日粮中的谷物饲料,这些饲料包括已木质化的植物细胞壁,如牧草、豆科植物、面粉加工厂及酒厂的副产品,它们均含高水平的纤维素残余物。猪大肠内的微生物区系比人体内的微生物区系能更好的适应木质化的牧草和副产品。猪大肠内的微生物区系包含高活性的反刍纤维素分解菌属和半纤维素分解菌,其中包括琥珀酸生产纤维菌(Fibrobacter succinogenes)、白瘤胃球菌属(Ruminococcus albus)、生黄瘤胃球菌(Rumin-ococcus flavefaciens)、丁酸弧菌属(Butyiviibriospp)及反刍类菌体(Prevotella ruminicola),最近从猪大肠内分离出一种新型高活性的纤维素分解菌——草食梭状芽孢杆菌(Clostridiumherbivorans)。随着纤维摄入量的增加,微生物的数量也增加,成年动物体内的纤维素分解菌的数量近似为生长猪的6.7倍,而在人大肠内未发现高活性的纤维素分解菌属,因此猪大肠内纤维发酵更像瘤胃发酵。 | 席鹏彬 Varel Yen | 1998 | 国外畜牧学(饲料)1998，，2： | 14 |
| 13 | 不同国家与地区老年健康服务模式的研究及对中国内地的启示显示文摘联合国及世界卫生组织从20世纪70年代开始就对全球性的人口老龄化及老年人口赡养问题给予重视,并提出实现'健康老龄化'的目标。本文选择美国、英国、日本与中国香港地区作为案例,介绍其老年健康服务模式,并分析值得借鉴的成果经验。为应对中国内地逐渐加剧的老龄化趋势和完善老年健康服务模式,建议:在'健康中国2030'的背景下,统筹多部门联合行动,补齐短板共同发展,关注需求多措并举,更加关注多因多果的慢性病预防与控制等,以老年人健康需求为核心来构建医养结合的老年照护服务体系。 | 王晓迪 Louis Yen 郭清 陈雅婷 胡俊江 | 2018 | 中国全科医学2018，21，10： | 13 |
| 14 | Genome-wide Scan for Seed Composition Provides Insights into Soybean Quality Improvement and the Impacts of Domestication and Breeding显示文摘优秀特点的复杂基因建筑学妨碍了努力在大豆修改种子营养素。染色体宽的协会研究为种子作文被进行,包括蛋白质,油,丰满的酸,和氨基酸,用有一个高密度的 SNP 数组的 313 多样的大豆 germplasm 就职 genotyped。87 个 chromosomal 区域的一个总数被识别与种子作文被联系,解释基因变化的 8%-89% 。已知的功能的候选人基因 GmSAT1, AK-HSDH, SACPD-C,和 FAD3A,和通常认为的 MtN21 nodulin, FATB,和 steroid-5 -- 涉及 N 2 固定,氨基酸生合成,和丰满的酸新陈代谢的 reductase 在主要效果的 loci 被发现。另外的 germplasm 就职的进一步的分析显示这些主要效果的 loci 受到了驯服或现代繁殖选择,并且突变而产生之遗传的变体和分布与地理区域相关。我们也表明与种子重量有关并且到全部的蛋白质的氨基酸集中有一个不同基因基础。这帮助揭开在种子之中的复杂关系的深入的基因机制加重。因此,我们的学习不仅为大豆营养素改进提供珍贵基因和标记,份量上和品质上,而且进在驯服期间优秀、引起的大豆的改变的提议卓见。 | Jiaoping Zhang Xianzhi Wang Yaming Lu Siddhi J. Bhusal Qijian Song Perry B. Cregan Yang Yen Michael Brown Guo-Liang Jiang | 2018 | Molecular Plant2018，11，3： | 12 |
| 15 | Cost-effectiveness analysis of population-based screening of hepatocellular carcinoma: Comparing ultrasonography with two-stage screening显示文摘AIM: To assess the cost-effectiveness of two populationbased hepatocellular carcinoma(HCC) screening programs, two-stage biomarker-ultrasound method and mass screening using abdominal ultrasonography(AUS).METHODS: In this study, we applied a Markov decision model with a societal perspective and a lifetime horizon for the general population-based cohorts in an area with high HCC incidence, such as Taiwan. The accuracy of biomarkers and ultrasonography was estimated from published meta-analyses. The costs of surveillance, diagnosis, and treatment were based on a combination of published literature, Medicare payments, and medical expenditure at the National Taiwan University Hospital. The main outcome measure was cost per lifeyear gained with a 3% annual discount rate. RESULTS: The results show that the mass screening using AUS was associated with an incremental costeffectiveness ratio of USD39825 per life-year gained, whereas two-stage screening was associated with an incremental cost-effectiveness ratio of USD49733 per life-year gained, as compared with no screening. Screening programs with an initial screening age of 50 years old and biennial screening interval were the most cost-effective. These findings were sensitive to the costs of screening tools and the specificity of biomarker screening.CONCLUSION: Mass screening using AUS is more cost effective than two-stage biomarker-ultrasound screening. The most optimal strategy is an initial screening age at 50 years old with a 2-year inter-screening interval. | Ming-Jeng Kuo Hsiu-Hsi Chen Chi-Ling Chen Jean Ching-Yuan Fann Sam Li-Sheng Chen Sherry Yueh-Hsia Chiu Yu-Min Lin Chao-Sheng Liao Hung-Chuen Chang Yueh-Shih Lin Amy Ming-Fang Yen | 2016 | World Journal of Gastroenterology2016，22，12： | 12 |
| 16 | Lessons in bridge damage learned from the Wenchuan earthquake显示文摘A strong earthquake occurred in Wenchuan County,Sichuan Province,China,on May 12,2008.Shortly after the earthquake,the Turner-Fairbank Highway Research Center of the Federal Highway Administration,in partnership with the Research Institute of Highways,the Ministry of Communication of China,led a reconnaissance team to conduct a post-earthquake bridge performance investigation of the transportation system in the earthquake affected areas.The U.S.transportation system reconnaissance team visited the area during July 20-24,2008.This paper presents the fi ndings and lessons learned by the team. | W. Phillip Yen Genda Chen Mark Yashinski Youssef Hashash Curtis Holu Wang Kehai GuoXiaodong | 2009 | Earthquake Engineering and Engineering Vibration2009，8，2： | 11 |
| 17 | miR-106b promotes cancer progression in hepatitis B virusassociated hepatocellular carcinoma显示文摘AIM: To investigate the effect of mi R-106 b on tumor progression in hepatitis B virus(HBV)-associated hepatocellular carcinoma(HCC).METHODS: A total of 120 patients who underwent liver resection for HCC at National Cheng Kung University Hospital were enrolled in the present study. Micro RNA(mi RNA) array was first used to screen the mi RNA expression profiles in HCC patients. The clinical records were retrospectively analyzed, and correlations with the mi RNA expression profiles were evaluated. The m RNA expression levels of the mi R-106b-25 cluster(mi R-106 b, mi R-93 and mi R-25), and MCM7 in tumor and non-tumor samples were quantitated using quantitative real-time reverse transcription-polymerase chain reaction(q-RT-PCR) analysis, and correlations in the levels of mi R-106 b, mi R-93 and mi R-25 expression were calculated. Kaplan-Meier overall and diseasefree survival rates of HBV-associated HCC patients were analyzed using the log-rank test based on mi R-106 b expression. The comparison of the mi R-106 b expression levels in patients with different clinical outcomes was analyzed using Mann-Whitney U tests. Furthermore, a hepatitis B virus X protein(HBx) expression plasmid was transfected into Huh7 and Hep 3B cells. The expression levels of the mi R-106b-25 cluster and MCM7 in HBx-expressing Huh7 and Hep 3B cells were detected using q-RT-PCR. RESULTS: mi RNA array screening showed that mi R-106 b and its cluster, mi R-93 and mi R-25 were upregulated in HCC patients(P < 0.01). The value of mi R-106 b expression in HBV-associated HCC patients was significantly higher than that in HCV-(P < 0.05) or non-B/non-C-(P < 0.001) associated HCC patients. The expression of the mi R-106b-25 cluster was significantly higher in tumor tissue(P < 0.001) and associated with the host gene, MCM7, in clinical specimens from HBVassociated HCC patients. Furthermore, the expression levels of mi R-106 b, mi R-93 and mi R-25 were positively correlated in HBV-associated HCC tissues(mi R-106 vs mi R-93, r = 0.75; mi R-93 vs mi R-25, r = 0.69; mi R-106 b vs mi R-25, r = 0.33). The overall and diseasefree survival curves showed that high-mi R-106 b expression was correlated with the poor prognosis of HBV-associated HCC. HCC differentiation was significantly correlated with mi R-106 b expression(P < 0.05). Lower mi R-106 b expression levels resulted in the well differentiation of HCC. Moreover, the expression of the mi R106b-25 cluster and MCM7 was up-regulated in Huh7 and Hep 3B cells after transfection with the HBx expression plasmid.CONCLUSION: The data obtained in the present study suggests that HBx enhances mi R-106 b transcription to promote tumor progression in HBV-associated HCC. | Chia-Sheng Yen Zhi-Ru Su Yi-Ping Lee I-Ting Liu Chia-Jui Yen | 2016 | World Journal of Gastroenterology2016，22，22： | 11 |
| 18 | Strengthening reinforced concrete beams using prestressed glass fiber-reinforced polymer-Part I: Experimental study显示文摘This work is aimed at studying the strengthening of reinforced concrete (R. C.) beams using prestressed glass fi- ber-reinforced polymer (PGFRP). Carbon fiber-reinforced polymer (CFRP) has recently become popular for use as repair or rehabilitation material for deteriorated R. C. structures, but because CFRP material is very stiff, the difference in CFRP sheet and concrete material properties is not favorable for transferring the prestress from CFRP sheets to R. C. members. Glass fi- ber-reinforced polymer (GFRP) sheets with Modulus of Elasticity quite close to that of concrete was chosen in this study. The load-carrying capacities (ultimate loads) and the deflections of strengthened R. C. beams using GFRP and PGFRP sheets were tested and compared. T- and ⊥-shaped beams were used as the under-strengthened and over-strengthened beams. The GFRP sheets were prestressed to one-half their tensile capacities before being bonded to the T- and ⊥-shaped R. C. beams. The prestressed tension in the PGFRP sheets caused cambers in the R. C. beams without cracks on the tensile faces. The PGFRP sheets also enhanced the load-carrying capacity. The test results indicated that T-shaped beams with GFRP sheets increased in load-carrying capacity by 55% while the same beams with PGFRP sheets could increase load-carrying capacity by 100%. The ⊥-shaped beams with GFRP sheets could increase load-carrying capacity by 97% while the same beams with PGFRP sheets could increase the loading-carrying capacity by 117%. Under the same external loads, beams with GFRP sheets underwent larger deflections than beams with PGFRP sheets. While GFRP sheets strengthen R. C. beams, PGFRP sheets decrease the beams’ ductility, especially for the over-strengthened beams (⊥-shaped beams). | WU Jong-hwei YEN Tsong HUNG Chien-hsing LIN Yiching | 2005 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2005，6，3： | 11 |
| 19 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis显示文摘 | Huang Norden E. Shen Zheng Long Steven R. Wu Manli C. Shih Hsing H. Zheng Quanan Yen Nai-Chyuan Tung Chi Chao Liu Henry H | 1998 | Proceedings of the Royal Society A: Mathematical Physical and Engineering Sciences1998，，1971： | 10 |
| 20 | Does computed tomography permeability predict hemorrhagic transformation after ischemic stroke?显示文摘AIM: To use perfusion-derived permeability-surface area product maps to predict hemorrhagic transformation following thrombolytic treatment for acute ischemic stroke.METHODS: We retrospectively analyzed our prospectively kept acute stroke database over five consecutive months for patients with symptoms of acute ischemic stroke(AIS) who had computed tomography(CT) perfusion(CTP) done at arrival. Patients included in the analyses also had to have a follow-up CT. The permeability-surface area product maps(PS) was calculated for the side of the ischemia and/or infarction and for the contralateral unaffected side at the same level. The cerebral blood flow map was used to delineate the ischemic territory. Next, a region of interest was drawn at the centre of this territory on the PS parametric map. Finally, a mirror region of interest was created on the contralateral side at the same level. The relative permeability-surface area product maps(r PS) provided an internal control and was calculated as the ratio of the PS on the side of the AIS to the PS on the contralateral side. A student t-test was performed after log conversion of r PS between patients with and without hemorrhagic transformation. Log conversion was used to convert the data into normal distribution to use t-test. For the group of patients who experienced intracranial bleed, a student t-test was performed between those with only petechial hemorrhage and those with more severe parenchymal hematoma with subarachnoid haemorrhage.RESULTS: Of 84 patients with AIS and CTP at admission, only 42 patients had a follow-up CT. The r PSderived using the normal side as the internal control was significantly higher(P = 0.003) for the 15 cases of hemorrhagic transformation(1.71 + 1.64) compared to 27 cases that did not have any(1.07 + 1.30). Patients with values above the overall mean r PS of 1.3 had an increased likelihood of subsequent hemorrhagic transformation. The sensitivity of using this score to predict hemorrhagic transformation was 71.4, the specificity was 78.6, with a positive predictive value of 62.5 and negative predictive value of 84.6. The accuracy was 76.2. The odds ratio of an event occurring with such an r PS was 9.2. Of the 15 cases of hemorrhagic transformation, there was no difference(P = 0.35) in the r PS between the eight cases of petechial and the seven cases of more severe hemorrhagic events.CONCLUSION: Pretreatment PS can predict the occurrence of hemorrhagic transformation on follow-up of AIS patients with relatively high sensitivity, specificity, positive and negative predictive value. | Peggy Yen Allison Cobb Jai Jai Shiva Shankar | 2016 | World Journal of Radiology2016，8，6： | 10 |
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