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| 1 | Outcome of 1355 consecutive transabdominal chorionic villus samplings in 1351 patients显示文摘Background The true risk of choronic villus sampling (C VS) is poorly defined. The objective of this study was to review the clinical o utcome of transabdominal CVS performed in a university teaching unit, with an em phasis on the complication rate. Methods A comprehensive audit database was maintained for 1351 pregnant women, including 17 sets of twin pregnancies, who had a CVS. Details a nd outcome of all CVSs made in the unit between May 1996 and May 2004 were revie wed. All CVSs were performed by one of 5 operators using the identical techniqu es. Results All procedures were performed transabdominally. A tota l of 1355 CVSs were performed because there were 4 dichorionic twin pregnancies which required 2 punctures. The mean gestation at CVS was (11.8±0.7) weeks, and 97.3% of the procedures were performed between 11 and 13 completed weeks. The majority (96.2%) required only 1 puncture to achieve correct needle placeme nt. The procedure failed to obtain an adequate sample in 4 subjects (0.30%). A total of 1351 chromosomal studies were requested and there was 1 case (0.07%) of culture failure. The results of chromosomal studies were available within 1 4 days in 36.7% of the cases and within 21 days in 94.0%. Overall, 77 chromos omal abnormalities (5.7%) and 5 cases of thalassemia major were detected. Preg nancy outcome was unknown in only 13 singleton subjects (0.96%). In the remain ing 1355 fetuses, there were 76 pregnancy terminations (5.56%), 10 fetal losses with obvious obstetric causes (0.73%), and 21 potentially procedure-relat ed fetal losses (1.54%). In the last group, the majority had one or more co-e xisting obstetric complications. The background fetal loss rate for pregnancies at similar gestational age in the unit was about 0.8%. Therefore, the procedu re-related fetal loss rate was estimated to be at the maximum of 0.74%. Conclusions In experienced hands, first trimester transabdomina l CVS is an accurate and safe invasive prenatal diagnostic procedure. It should be one of the treatment options available to pregnant women who require prenata l genetic diagnosis. | LAU Tze Kin LEUNG Tak Yeung FUNG Tak Yuen Daljit S SAHOTA LEUNG Tse Ngong | 2005 | Chinese Medical Journal2005，，20： | 8 |
| 2 | 新加坡成人慢性呼吸系统疾病患者6分钟步行距离的最小临床重要差异值研究(英文)显示文摘目的:6 min步行距离(6MWD)是临床上常见的功能性运动能力测试,特别是对于慢性呼吸系统疾病患者。一些文献记载了关于白种人的6MWD的最小临床重要差异(MCID),但对亚洲人群的相关信息未见记载。本研究旨在建立亚洲成人慢性呼吸道疾病患者6MWD的最小临床重要差异。方法:采用'锚定'法和'分布'法对新加坡中央医院肺康复计划登记处的资料进行了分析。'锚定'法收集确诊为慢性呼吸道疾病的患者50例,其中男38例,女12例;平均年龄(64.2±12.3)岁,通过电话采访及使用整体变化评估量表(GROC)评价患者肺康复计划后的自觉改善程度,再将患者在肺康复计划中6MWD的改变数值与相对应的患者自觉改善程度进行比较,这种关系用操作特征曲线(ROC)统计表示。通过'分布'法确定6MWD的MCID,从门诊和住院的肺康复计划(PRP)参与者中检索医疗记录136例,其中男103例,女33例;平均年龄(60.1±14.1)岁。结果 :ROC曲线表明6MWD出现临床显著性变化的最佳临界值为17.4 m,其对应的敏感性为79.4%,特异性为81.3%,阳性似然比为4.23。由'分布'法确定6MWD的最小临床重要差异值为18.6 m。结论:18.6 m为新加坡华人6MWD的最小临床重要差异的估计值。 | Meredith T L YEUNG Alan W P WONG Katherine S L HUANG Alice Y M JONES | 2015 | 康复学报2015，25，1： | 3 |
| 3 | Sliding-mode control of multilink flexible manipulators 显示文摘 | Chen Y P Yeung K S | 1991 | Int J Control1991，54，2： | 2 |
| 4 | Robust Adaptive Control of Induction Motors Without Flux Measurment显示文摘 | Kwan C M Lewis F L Yeung K S | 1995 | ACC1995，32，6： | 1 |
| 5 | The role of charge-transfer integral in determining and engineering the carrier mobilities of 9,10-di( 2- naphthyl) anthracene compounds显示文摘 | Tse S C So S K Yeung M Y | 2006 | Chem Phys Lett2006，422，： | 1 |
| 6 | A Comparative Study on Heuristic Algorithms for Generating Fuzzy Decision Trees 显示文摘 | WANG X Z YEUNG D S TSANG E C C | 2001 | IEEE Transactions on systems Man and Cybernetics2001，31，2： | 1 |
| 7 | Formal description and verification of hybrid rule/frame-based expert systems 显示文摘 | Shiu S C K Liu J N K Yeung D S | 1997 | Expert Systems with Applications1997，13，3： | 1 |
| 8 | A simple chemical vapor deposition method for depositing thin titanium dioxide films显示文摘 | YEUNG K S LAM Y W | 1983 | Thin Solid Films1983，109，： | 1 |
| 9 | A multilevel weighted fuzzy reasoning algorithm for expert systems显示文摘 | Yeung D S Tsang E C C | 1998 | IEEE Transaction on System Man and Cybernetics-part A1998，28，2： | 1 |
| 10 | Do Corporate Global Environmental Standards Create or Destroy Market Value? 显示文摘 | Dowell G Hart S L Yeung B | 2000 | Management Science2000，46，8： | 1 |
| 11 | Functional production and characterization of a fibrin-specific single-chain antibody fragmentfrom Bacillus subtilis:effects of molecular chaperones and a wall-bound protease on antibody fragment production显示文摘 | Wu S C Yeung J C Wong S L | 2002 | ApplEnviron Microbiol2002，68，7： | 1 |
| 12 | Polymorphism of the IL-4 ,TNF-a|pha, and Fcepsi|on RIbeta genes and the risk of allergic disorders in at-risk infants显示文摘 | Zhu S Chan Yeung M Becker AB | 2000 | Am J Respir Crit Care Med2000，161，5： | 1 |
| 13 | Linear network coding显示文摘 | Li S Y Yeung R W | | 0，，： | 1 |
| 14 | Effect of subgrid models on the computed interscale energy transfer in isotropie turbulence 显示文摘 | MENON S YEUNG P KIM W | 1996 | Computer and Fluids1996，25，2： | 1 |
| 15 | On the handling of Interaction in Fuzzy Production Rule reasouing显示文摘 | Yeung D S Ha M H Wang X Z | 2004 | IEEE2004，，： | 1 |
| 16 | Image classification with the use of radial basis function neural networks and the minimization of the loealized generalization error显示文摘 | Wing W Y N Dorado A Yeung D S | 2007 | Pattern Recognition2007，40，： | 1 |
| 17 | Network information flow 显示文摘 | Ahlswede R Cai N Li S Y R and Yeung R W | 2000 | IEEE Transactions on Information Theory2000，46，4： | 1 |
| 18 | Human Oviductal Cells Produce a Factor(s) That Maintains the Motility of Human Spermatozoa in Vitro显示文摘 | YAO Yuan-qing Ho P C Yeung W S B | 2000 | Fertil Steril2000，73，3： | 1 |
| 19 | Aggressive school troublemakers and victims: a longitudinal model examining the pivotal role of self-concept 显示文摘 | Marsh HW Parada R H Yeung A S | 2001 | Journal of Educational Psychology2001，93，2： | 1 |
| 20 | Linear network coding显示文摘 | LI S Y R YEUNG R W CA1 N | 2003 | IEEE Transactions on Information Theory2003，49，2： | 1 |
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