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| 1 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 2 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 3 | Mechanisms of the apoptosis induced by CD176 antibody in human leukemic cells显示文摘 | Yi B Zhang M Schwartz-Albiez R | | 0，，06： | 1 |
| 4 | MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms 显示文摘 | Zeng Y Yi R Cullen B R | 2003 | PNAS2003，100，17： | 1 |
| 5 | Recognition and cleavage of primary microRNA precursors by the nuclear process ing enzyme Drosha显示文摘 | Zeng Y Yi R Cullen B R | 2005 | EMBO J2005，24，1： | 1 |
| 6 | The draft genome of watermelon (Citrullus lanatus ) and reseqnencing of 20 diverse accessions显示文摘 | Guo S G Zhang J G Sun H H Salse J Lucas W J Zhang H Y Zheng Y Mao L Y Ren Y WangZ W Min J M Guo X S Murat F Ham B K Zhang Z L Gao S Huang M Xu Y M Zhong S L Bombarely A Mueller L Zhao H He H Q Zhang Y Zhang Z H Huang S W Tan T Pang E Lin K Hu Q Kuang H H Ni P X Wang B Liu J G Kou Q H Hou W J Zou X H Jiang J Gong G Y Klee K Schoof H Huang Y Hu X S Dong S S Liang D Q Wang J Wu K Xia Y Zhao X Zheng Z Q Xing M Liang X M Huang B Q Lv T Wang J Y Yin Y Yi H P Li R Q Wu M Z Levi A Zhang X P Giovannoni J Wang J Li YF Fei Z J Xu Y | 2013 | Nature genetics2013，45，1： | 1 |
| 7 | Molecular mechanisms and in vivo mouse models of skin aging associated with dermal matrix alterations显示文摘 | Hwang K A Yi B R Choi K C | 2011 | Lab Anim Res2011，27，： | 1 |
| 8 | MicroRNAs and small interferingRNAs can inhibit mRNA expresion by similar mechanisms显示文摘 | Zeng Y Yi R Cullen B R | 2003 | Proc Nat Acad Sci USA2003，100，17： | 1 |
| 9 | Gastrochilus brevifimbriatus(Orchidaceae, Aeridinae), a new species from Chongqing, China 显示文摘 | YI S R HUANG Y XIAO B | 2010 | Novon2010，20，11： | 1 |
| 10 | Valsartan inhibited HIF - lalpha path- way and attenuated renal interstitial fibrosis in streptozotocin - diabetic rats 显示文摘 | Tang L Yi R Yang B | 2012 | Diabetes Research and Clinical Practice2012，97，1： | 1 |
| 11 | FOXP3-miR-146-NF-K B axis and therapy for precancerous lesions in prostate 显示文摘 | Liu R Yi B Wei S | 2015 | Cancer Res2015，75，8： | 1 |
| 12 | Scaling-up plasticating screw extruders on the basis of similar melting performance 显示文摘 | Yi B Fenner R T | 1976 | Plastics and Rubber : Processing1976，1，： | 1 |
| 13 | Performances of proton exchange membrane fuel cells with alternate membranes 显示文摘 | DU X Z YU J R YI B L | 2001 | Phys Chem: Chem Phys2001，3，15： | 1 |
| 14 | Deformation and texture evolution in AZ31 magnesium alloy during uniaxial loading显示文摘 | YI S B DAVIES C H J BROKMEIE H G BOLMARO R E | 2006 | Acta Materialia2006，54，： | 1 |
| 15 | 查看详情显示文摘 | Hu G Y Zhang J Y Zheng J Shen B F Liu S Y Yang J M Ding Y K Hu X Huang Y X Du H B Yi R Q Lei A L Xu Z Z | | 0，，： | 1 |
| 16 | Effect of nitrogen on blood compatibility of nickel-free high nitrogen stainless steel for biomaterial显示文摘 | Wan P Yi R B Zhang B C | | 0，，08： | 1 |
| 17 | Genistein,a soy phytoestrogen,prevents the growth of BG-1 ovarian cancer cells induced by 17β-estradiol or bisphenol A via the inhibition of cell cycle progression显示文摘 | Hwang K A Kang N H Yi B R | | 0，，02： | 1 |
| 18 | 显示文摘 | Yi Q Desikan R Barlogie B | 2002 | Br J Haematol2002，117，2： | 1 |
| 19 | MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms显示文摘 | ZENG Yan YI Rui CULLEN B R | 2003 | Proceedings of the National Academy of Sciences USA2003，100，17： | 1 |
| 20 | Eigenvalue solution of thermoelastic instability problems using Fourier reduction显示文摘 | Yi B Y Barber J R Zagrodzki P | 2000 | Pro- eeedings of the Royal Society of London A2000，456，： | 1 |
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