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| 1 | 用碳化养护电弧熔炉钢渣制备集料和混凝土显示文摘将电弧熔炉(electricarc furnace,EAF)钢渣和石灰混和制成球状集料,置于密闭容器当中,并通入100%的CO2气体进行碳化,在0.5066MPa保持2h。通过质量法测定添加质量分数为11.94%石灰的EAF钢渣(下同)集料CO2的吸收率为5%,通过红外光谱(infrared,IR)分析测定CO2的吸收率为13.88%。用碳化的钢渣集料制备混凝土再进行碳化养护,同时利用碎石和河砂为集料制备碳化混凝土作为参比样。用质量法测定2种混凝土的碳化率分别为21.14%和10.57%;用IR法的为13.81%和16.97%。碳化后电弧熔炉钢渣集料内生长着大量簇生的犬牙状碳酸钙晶体。 | 常钧 WANG Sanwu SHAO Yixin | 2007 | 硅酸盐学报2007，35，9： | 31 |
| 2 | Aspirin combined with mechanical measures to prevent venous thromboembolism after total knee arthroplasty: a randomized controlled trial显示文摘 | Jiang Yi Du Hui Liu Jian Zhou Yixin | 2014 | Chinese Medical Journal2014，，12： | 22 |
| 3 | 14-3-3 mediates apeHn-13-induced enhancement of adhesion of monocytes to human umbilical vein endothelial cells显示文摘调查 apelin-13 是否导致了 THP-1 单核白血球(MC ) 对经由表明 transduction 小径和潜在的小说的 14-3-3 的 ECV304 人的脐的静脉 endothelial 房间(HUVEC ) 的粘附生理的功能和 apelin-APJ 的发信号的 transduction 小径, HUVEC ECV304 在 DMEM 和 MC THP-1 是有教养的在 RPMI 1640 是有教养的中等。单核白血球粘附和脉管的房间粘附 molecule-1 (VCAM-1 ) 和 14-3-3 的表示与单核白血球粘附试金和西方的污点分析被测量。数据证明 apelin-13 在一个集中依赖者和时间依赖者举止增加了 MC 的粘附到 HUVEC,它分别地在 1 M 和 12 h 到达了他们的山峰。同样, apelin-13 导致了 HUVEC 粘附分子的表示,在一个集中依赖者和时间依赖者举止, VCAM-1 分别地在 1 M 和 12 h 到达了他们的山峰。Apelin-13 在一个集中依赖者和时间依赖者举止导致了 14-3-3 的表示,它分别地在 1 M 和 5 min 到达了他们的山峰。而且,有势力 14-3-3 禁止者 difopein 显著地减少了 14-3-3 的表示,在 apelin-13 的 VCAM-1 刺激了 HUVEC,并且 difopein 显著地在对 HUVEC 的 MC 粘附的正式就职上禁止了 apelin-13 的效果。这些数据建议 14-3-3 调停了到由 Apelin-13 的 HUVEC 的 MC 的粘附的正式就职。 | Xin Li Xianhui Zhang Fang Li Linxi Chen Lanfang Li Xuping Qin Jing Gao Tao Su Yixin Zeng Duanfang Liao | 2010 | Acta Biochimica et Biophysica Sinica2010，42，6： | 21 |
| 4 | Janus(BNNS/ANF)-(AgNWs/ANF)thermal conductivity composite films with superior electromagnetic interference shielding and Joule heating performances显示文摘Highly thermal conductivity materials with excellent electromagnetic interference shielding and Joule heating performances are ideal for thermal management in the next generation of communication industry,artificial intelligence and wearable electronics.In this work,silver nanowires(AgNWs)are prepared using silver nitrate as the silver source and ethylene glycol as the solvent and reducing agent,and boron nitride(BN)is performed to prepare BN nanosheets(BNNS)with the help of isopropyl alcohol and ultrasonication-assisted peeling method,which are compounded with aramid nanofibers(ANF)prepared by chemical dissociation,respectively,and the(BNNS/ANF)-(AgNWs/ANF)thermal conductivity and electromagnetic interference shielding composite films with Janus structures are prepared by the'vacuum-assisted filtration and hot-pressing'method.Janus(BNNS/ANF)-(AgNWs/ANF)composite films exhibit'one side insulating,one side conducting'performance,the surface resistivity of the BNNS/ANF surface is 4.7×10^(13) Ω,while the conductivity of the AgNWs/ANF surface is 5,275 S/cm.And Janus(BNNS/ANF)-(AgNWs/ANF)composite film with thickness of 95 pm has a high in-plane thermal conductivity coefficient of 8.12 W/(m·K)and superior electromagnetic interference shielding effectiveness of 70 dB.The obtained composite film also has excellent tensile strength of 122.9 MPa and tensile modulus and 2.7 GPa.It also has good temperature-voltage response characteristics(high Joule heating temperature at low supply voltage(5 V,215.0℃),fast response time(10 s)),excellent electrical stability and reliability(stable and constant real-time relative resistance under up to 300 cycles and 1,500 s of tensile-bending fatigue work tests). | Yixin Han Kunpeng Ruan Junwei Gu | 2022 | Nano Research2022，15，5： | 20 |
| 5 | Holocene high lake-levels and pan-lake period on Badain Jaran Desert显示文摘Many lakes exist in southeastern Badain Jaran Desert and its hinterland, including 110 perennial lakes and some seasonal or extinct lakes. Geomorphological, sedimentological, and bioglyph evidence obtained from field investigations on Badain Jaran Desert lake group, alongside measurements and dating performed on lake relic, prove that these lakes expanded while the climate was relatively wet during early and middle Holocene. The dating results suggest that the pan-lake period of the Badain Jaran Desert began at 10 cal kyr BP, before which the limnic peat period occurred(11–10 cal kyr BP). Many lakes reached their maximal water-level during 8.6–6.3 cal kyr BP and retreated or dried up in the late Holocene(about 3.5–0 cal kyr BP). During that period, the precipitation at Badain Jaran Desert may have reached 200 mm yr^(-1) for 7.7–5.3 cal kyr BP, inferred from both the age and precipitation rate of calcareous root tubes. The water balance calculation shows that wetter and warmer climate and the increase of underground water recharge were key factors in maintaining and developing the lake group at both centennial and millennial time scales. Furthermore, lake surface expansion and the increasing fresh water availability set the background for the prosperous prehistoric culture. | WANG NaiAng NING Kai LI ZhuoLun WANG YiXin JIA Peng MA Ling | 2016 | Science China Earth Sciences2016，59，8： | 19 |
| 6 | Thick-skinned Contractional Salt Structures in the Kuqa Depression,the Northern Tarim Basin:Constraints from Physical Experiments显示文摘摘要:脸皮厚的 contractional 盐结构广泛地在西方的 Kuqa 消沉被开发,北 Tarim 盆。为了理解管理这些的发展的机制,组织,物理实验被进行,结果证明他们被地下室差错并且形成 paleo 高举和地下室斜坡的活动大部分管理。在这研究的模型材料是干燥的沙,矿脂和 plasticene (或难泡沫) ,分别地模仿 suprasalt,盐,和 subsalt 层。实验证明由于地下室差错并且形成 paleo 高举的活动,盐身体通常在被预先退出的边界差错抑制的 paleo 高举的中间的顶上显著地积累并且变厚。大规模戳差错和盐越过水坝落下的水的发展被地下室赞成与更大的剧降泼出。实验也断定因为盐层的存在,那微分结构的变丑能发生在 subsalt 和 suprasalt 层之间。他们的几何学和结构的高度的地点是不同的,尽管有高举的区域的大类似。穿透的盐挤入构造没在实验被观察,它显示弄短的 contractional 有效地不加速盐挤入构造的发展。 | YU Yixin TANG Liangjie YANG Wenjing JIN Wenzheng PENG Gengxin LEI Ganglin | 2008 | Acta Geologica Sinica(English Edition)2008，82，2： | 15 |
| 7 | Photochemical pollution in Lanzhou, China - A case study显示文摘The photochemical air pollution in Xigu district of Lanshou city, Gansu Province was studied during a period of 1981-1984. The extremely high NMHC/NOx ratio and ozone level elevation after rain have been noticed. A series of outdoor and indoor reaction chamber simulation experiments conducted in order to understand the specific conditions. The ozone formation under NMHC/NOx condition and the possible reason for high ozone concentration after rain are discussed. | Tang Xiaoyan , Li Jinglong, Dong ZhenXing, Wang Yuying,Wang Wenxing , Qi Liwen, Liu Xiling, Zhang Yutian, Zhang Xuejin,Tian Bingshen, Jin Suwen , Yang Lingqing and Zhang Yixin Department of Technical Physics,Peking University, Beijing, China. Chinese Reaearch Academy of Eavironmental Sciences, Beijing,China. Gansu Provincial Environmental Research Institute, Lanshou, China. Lanshou Petrochemical Engineering Institute, Lanshou, China. | 1989 | Journal of Environmental Sciences1989，1，1： | 15 |
| 8 | Probabilistic steady-state and dynamic security assessment of power transmission system显示文摘Two-level system model based probabilistic steady-state and dynamic security assessment model is introduced in this paper.Uncertainties of nodal power injection caused by wind power and load demand,steady-state and dynamic security constraints and transitions between system configurations in terms of failure rate and repair rate are considered in the model.Time to insecurity is used as security index.The probability distribution of time to insecurity can be obtained by solving a linear vector differential equation.The coefficients of the differential equation are expressed in terms of configuration transition rates and security transition probabilities.The model is implemented in complex system successfully for the first time by using the following effective measures:firstly,calculating configuration transition rates effectively based on component state transition rate matrix and system configuration array;secondly,calculating the probability of random nodal power injection belonging to security region effectively according to practical parts of critical boundaries of security region represented by hyper-planes;thirdly,locating non-zero elements of coefficient matrix and then implementing sparse storage of coefficient matrix effectively;finally,calculating security region off-line for on-line use.Results of probabilistic security assessment can be used to conduct operators to analyze system security effectively and take preventive control.Test results on New England 10-generators and 39-buses power system verify the reasonableness and effectiveness of the method. | LIU YanLi YU YiXin | 2013 | Science China(Technological Sciences)2013，56，5： | 13 |
| 9 | Fuzzy energy management strategy for parallel HEV based on pigeon-inspired optimization algorithm显示文摘Improvements in fuel consumption and emissions of hybrid electric vehicle(HEV)heavily depend upon an efficient energy management strategy(EMS).This paper presents an optimizing fuzzy control strategy of parallel hybrid electric vehicle em- | PEI JiaZheng SU YiXin ZHANG DanHong | 2017 | Science China(Technological Sciences)2017，60，3： | 13 |
| 10 | Selective separation of Cu(Ⅱ),Zn(Ⅱ),and Cd(Ⅱ)by solvent extraction显示文摘试验性的调查在分离上被介绍 Cu (II ) , Zn (II ) ,和从锌的富有的硫酸盐 leachate 的 Cd (II ) 由溶剂抽取起炉渣。直角的实验的结果显示 LIX 984N 在 Cu ( II )的抽取高度选择、很有效,并且变化的分析显示参数的顺序根据他们对分离效率的影响是阶段比率> LIX 984N 集中> pH 价值>抽取时间。为铜抽取的最佳的条件作为 25% LIX 984N 集中,抽取时间的 7 min,阶段比率记帐的 3:2,和 pH = 被获得 1.7。Zn (II ) 和 Cd (II ) 的分离从 raffinate 在铜抽取以后被执行。有 di-2-ethylhexyl 的分离的比较分析磷的酸(D2EHPA ) , D2EHPA- tributylphosophate (TBP ) synergistic 提取系统,和 2-ethylhexyl 单音的 2-ethylhexyl 酉旨(HEHEHP ) 在 pH = 被做的磷的酸 2.0。有 D2EHPA 的抽取效率在被钠氢氧化物,并且 D2EHPA-TBP synergistic 提取以及 HEHEHP 皂化以后被改进,这被表明,在 Cd (II ) 上有一种优异选择到 Zn (II ) 。 | XIE Keng WEN Jiankang HUA Yixin RUAN Renman | 2008 | Rare Metals2008，27，3： | 11 |
| 11 | Security value based expansion planning of power system with integration of large-scale wind power显示文摘Concerning the integration of large-scale wind power,an integrated model of generation and transmission expansion planning is proposed based on the assessment of the value of steady state and dynamic security.In the assessment of security value,the unit commitment simulation based on the predicted hourly load and wind power output data in the planning horizon is used to evaluate the costs of preventive control,emergency control and social losses due to the uncertainty of load and wind power.The cost of preventive control consists of the fuel cost of power generation,the environmental cost and the load shedding cost.This not only provides a systematic method of security assessment of power system expansion planning schemes,but also broadens the perspective of power system planning from the technology and economic assessment to the measure of the whole social value.In the assessment process,the preventive control and emergency control of cascading failures are also presented,which provides a convincing tool for cascading failure analysis of planning schemes and makes the security assessment more comprehensive and reasonable.The proposed model and method have been demonstrated by the assessment of two power system planning schemes on the New England 10-genarator 39-bus System.The importance of considering the value of security and simulating hourly system operation for the planning horizon,in expansion planning of power system with integration of large-scale wind power,has been confirmed. | YU YIXin WANG JingRan LV XiaoYang | 2012 | Science China(Technological Sciences)2012，55，7： | 11 |
| 12 | Prognostic value of preoperative prognostic nutritional index and its associations with systemic inflammatory response markers in patients with stage Ⅲ colon cancer显示文摘Background: The prognostic nutritional index(PNI) has been widely applied for predicting survival outcomes of patients with various malignant tumors. Although a low PNI predicts poor prognosis in patients with colorectal cancer after tumor resection, the prognostic value remains unknown in patients with stage Ⅲ colon cancer undergoing curative tumor resection followed by adjuvant chemotherapy. This study aimed to investigate the prognostic value of PNI in patients with stage III colon cancer.Methods: Medical records of 274 consecutive patients with stage Ⅲ colon cancer undergoing curative tumor resection followed by adjuvant chemotherapy with oxaliplatin and capecitabine between December 2007 and December2013 were reviewed. The optimal PNI cutoff value was determined using receiver operating characteristic(ROC) curve analysis. The associations of PNI with systemic inflammatory response markers, including lymphocyte-to-monocyte ratio(LMR), neutrophil-to-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio(PLR), and C-reactive protein(CRP)level, and clinicopathologic characteristics were assessed using the Chi square or Fisher's exact test. Correlation analysis was performed using Spearman's correlation coefficient. Disease-free survival(DFS) and overall survival(OS)stratified by PNI were analyzed using Kaplan-Meier method and log-rank test, and prognostic factors were identified by Cox regression analyses.Results: The preoperative PNI was positively correlated with LMR(r= 0.483, P < 0.001) and negatively correlated with NLR(r =-0.441, P < 0.001), PLR(r =-0.607, P < 0.001), and CRP level(r =-0.333, P < 0.001). A low PNI(≤49.22)was significantly associated with short OS and DFS in patients with stage ⅢC colon cancer but not in patients with stage ⅢA/ⅢB colon cancer.In addition, patients with a low PNI achieved a longer OS and DFS after being treated with6-8 cycles of adjuvant chemotherapy than did those with < 6 cycles. Multivariate analyses revealed that PNI was independently associated with DFS(hazard ratios 2.001; 95% confidence interval 1.157-3.462; P = 0.013).Conclusion: The present study identified preoperative PNI as a valuable predictor for survival outcomes in patients with stage Ⅲ colon cancer receiving curative tumor resection followed by adjuvant chemotherapy. | Jianhong Peng Rongxin Zhang Yixin Zhao Xiaojun Wu Gong Chen Desen Wan Zhenhai Lu Zhizhong Pan | 2017 | Chinese Journal of Cancer2017，36，11： | 11 |
| 13 | A Theory of Semantic Information(Invited Paper)显示文摘The information really useful to humans must be the trinity of its three components: the form termed syntactic information, the meaning termed semantic information, and the utility termed pragmatic information. But the theory of information set up by Shannon in 1948 is a statistical theory of syntactic information. Thus, the trinity of information theories needs to be established as urgently as possible. Such a theory of semantic information will be presented in the paper and it will also be proved that it is the semantic information that is the unique representative of the trinity. This is why the title of the paper is set to 'a theory of semantic information' without mentioning the pragmatic information. | Yixin Zhong | 2017 | China Communications2017，14，1： | 11 |
| 14 | Using balance of seasonal herbage supply and demand to inform sustainable grassland management on the Qinghai–Tibetan Plateau显示文摘To mitigate the impacts of grassland degradation on the Qinghai–Tibetan Plateau(QTP), in recent decades China has been implementing large-scale conservation programs and has invested about 42 billion CNY(7 billion USD). However, these programs are faced with major challenges involving trade-offs between ecological function, livestock production and income of pastoralists.Scientific assessments, as well as technical and policy issues, have not fully captured the complex ecological,social and economic dynamics of the challenges facing grassland management on the QTP. Pastoral livestock production on the QTP is characterized by imbalance in both quality and quantity between livestock seasonal nutrient requirements and herbage production, which forces pastoralists to keep larger numbers of livestock for longer periods, leading to overgrazing. To solve these problems, an integrated crop-livestock system is promoted to improve the efficiency of livestock production and conserve natural grassland as well for a sustainable system for the QTP. | Xinquan ZHAO Liang ZHAO Qi LI Huai CHEN Huakun ZHOU Shixiao XU Quanmin DONG Gaolin WU Yixin HE | 2018 | Frontiers of Agricultural Science and Engineering2018，5，1： | 11 |
| 15 | THREE DIMENSIONAL NONLINEAR NUMERICAL MODEL WITH INCLINED PRESSURE FOR SALTWATER INTRUSION AT THE YANGTZE RIVER ESTUARY显示文摘A three dimensional nonlinear numerical model with inclined pressure was developed to compute the saltwater intrusion at the Yangtze River Estuary. The σ transformation was introduced in the vertical plane to achieve the same lattices in the whole domain of interest. The mode splitting technique splits the three dimensional governing equations into the surface gravity waves (external mode) and the internal gravity waves (internal mode). And the external mode was solved by the improved double sweep implicit (DSI) finite difference method and the internal mode was solved by the Eulerian Lagrangian method. The Eulerian Lagrangian method could not only reduce the numerical diffusion but also increase the computational accuracy by the improvement of the finite difference scheme in the vertical direction. Application of the model to the Yangtze River Estuary was carried out for the calculation of the saltwater intrusion and the null point. Results of the temporal and spatial distribution of the flow velocity and the salinity coincide with the measured data quite well. The formation and location of the underwater sandbars in the North Channel of the Yangtze River Estuary are closely related to the local salinity, the null point, the predominant current and the residual flow. | Zhu, Yuliang Zheng, Jinhai Mao, Lihua Yan, Yixin | 2000 | Journal of Hydrodynamics2000，12，1： | 10 |
| 16 | Vitamin B2 functionalized iron oxide nanozymes for mouth ulcer healing显示文摘Mouth ulcer is associated with inflammation and high risk of bacterial infection, which aggravates the patient's condition.Currently, there is no effective treatment for mouth ulcer. Herein, we report that vitamin-modified iron oxide nanoparticles improve the healing of mouth ulcer through anti-inflammation and antibacterial activities. We discovered that vitamin B2(VB2)modified iron oxide nanoparticles performed enhanced peroxidase-like, catalase-like, and superoxide dismutase(SOD)-like activities, acting as typical iron oxide nanozymes(IONzymes) with triad activities. In particular, VB2 modification significantly improved the SOD-like activity, thus providing a reactive oxygen species(ROS)-scavenging ability. Cellular antioxidant experiments showed that vitamin B2 modified IONzymes(VB2-IONzymes) protect human oral keratinocytes(HOK) and BALB/3 T3 cells from hydrogen peroxide(H2O2), and these cells have high biocompatibility to eukaryotic cells. In addition, VB2-IONzymes exerted an antibacterial activity against Streptococcus mutans, Staphylococcus aureus, and Escherichia coli. Importantly, VB2-IONzymes accelerated the recovery of mouth ulcer and reduced the local secretion of inflammatory factors in mouse ulcer model via ROS scavenging and antibacterial activity. Taken together, our work demonstrates that vitamin B2 modification endows iron oxide nanoparticles with enhanced enzyme-like activities and VB2-IONzymes may be a promising reagent in the treatment of mouth ulcer because of their intrinsic anti-inflammation and antibacterial capabilities. | Yunhao Gu Yixin Huang Zhiyue Qiu Zhuobin Xu Dandan Li Lei Chen Jing Jiang Lizeng Gao | 2020 | Science China(Life Sciences)2020，63，1： | 10 |
| 17 | Tectonic Evolution of the Middle Frontal Area of the Longmen Mountain Thrust Belt,Western Sichuan Basin,China显示文摘由分析平衡的生气的节和 Longmen 山戳带的沉淀历史,中国,我们断定它经历了五个构造阶段:(1 ) 形成阶段(T 3 x ) Longmen 的缩影,山,早 Indosinian 运动,和 Anxian 构造运动创造了 Longmen 山;(2 ) 稳定的构造阶段(更弱的构造运动导致了 Longmen 山戳带的 J 1) 稍微正在被高举并且稍微减退低岬盆;(3 ) 强烈构造阶段(J2.3 ) ,也就是早 Yanshan 运动;(4 ) 连续构造运动(K-E ) ,也就是迟了的 Yanshan 运动和早喜玛拉雅的运动;并且(5 ) Longmen 山(N-Q ) 的形成,也就是晚喜玛拉雅的运动。在那些构造变丑阶段期间, Anxian 运动和喜玛拉雅的运动在 Longmen 山的形成起了重要作用。喜玛拉雅的运动影响了 Longmen 山大多数;阶层强烈地推进了并且严重地被侵蚀。因为一些越过水坝落下的水被推,在 Longmen 山戳带的中间的部分有某 klippes 在以后向东南构造变丑。 | JIN Wenzheng TANG Liangjie YANG Keming WAN Guimei Lü Zhizhou YU Yixin | 2009 | Acta Geologica Sinica(English Edition)2009，83，1： | 10 |
| 18 | Theory and Method of Power System Integrated Security Region Irrelevant to Operation States:An Introduction显示文摘How to comprehensively consider the power flow constraints and various stability constraints in a series of power system optimization problems without affecting the calculation speed is always a problem.The computational burden of probabilistic security assessment is even more unimaginable.In order to solve such problems,a security region(SR)methodology is proposed,which is a brand-new methodology developed on the basis of the classical point-wise method.Tianjin University has been studying the SR methodology since the 1980s,and has achieved a series of original breakthroughs that are described in this paper.The integrated SR introduced in this paper is mainly defined in the power injection space,and includes SRs to ensure steady-state security,transient stability,static voltage stability,and smalldisturbance stability.These SRs are uniquely determined for a given network topology(as well as location and clearing process for transient faults)and given system component parameters,and are irrelevant to operation states.This paper presents 11 facts and related remarks to introduce the basic concepts,composition,dynamics nature,and topological and geometric characteristics of SRs.It also provides a practical mathematical description of SR boundaries and fast calculation methods to determine them in a concise and systematic way.Thus,this article provides support for the systematic understanding,future research,and applications of SRs.The most critical finding on the topological and geometric characteristics of SRs is that,within the scope of engineering concern,the practical boundaries of SRs in the power injection space can be approximated by one or a few hyperplanes.Based on this finding,the calculation time for power system probabilistic security assessment(i.e.,risk analysis)and power system optimization with security constraints can be decreased by orders of magnitude. | Yixin Yu Yanli Liu Chao Qin Tiankai Yang | 2020 | Engineering2020，6，7： | 10 |
| 19 | Relation of hepatic EROD activity and cytochrome P4501A level in Sebastiscus marmoratus exposed to benzo[a]pyrene显示文摘这研究被设计调查 benzo 的体内效果[一]有细胞色素 P4501A ( CYP1A )蛋白质的活动和它的关联在 Sebastiscus marmoratus 铺平的肝的 ethoxyresorufin-O-deethylase (侵蚀)上的分核( BaP )通过水列暴露于 BaP , 10 , 100 , 1000 ng/L ,分别地)或与 BaP 的 intraperitoneal 注射被对待( 0.5 , 1 , 5 , 10 mg/kg ,分别地)每 7 d 。结果证明在到 1000 ng/L BaP 的水运的暴露的 25 d 以后,捞肝的 CYP1A 层次和侵蚀活动显著地被导致。相反,侵蚀活动没被改变在第二 intraperitoneal 注射以后的 7 d,而, CYP1A 蛋白质层次被增加。胆汁的 BaP 代谢物的剂量依赖者增加证明 CYP1A 的催化活动被处理与 BaP 导致。关于胆汁的 BaP 代谢物(100 ng/L ) 的最低可见效果集中与侵蚀活动(1000 ng/L ) 的参考是比那低得多的。结果建议那胆汁的多不的芳族烃(哼) 代谢物被显示更好反映污染坡度比侵蚀哼活动。它看起来必要测量 CYP1A 蛋白质层次在相关毒物学的评价补充 EROD 活动。 | WANG Yun ZHENG Ronghui ZUO Zhenghong CHEN Yixin WANG Chonggang | 2008 | Journal of Environmental Sciences2008，20，1： | 10 |
| 20 | Ⅲ期结肠癌患者术前预后营养指数的预后价值及其与全身炎症反应标志物的相关性显示文摘背景与目的预后营养指数(prognostic nutritional index,PNI)已广泛应用于预测各种恶性肿瘤患者的生存结局。虽然低PNI预测肿瘤切除后的结直肠癌患者的预后不良,但对接受根治性肿瘤切除术后辅助化疗的Ⅲ期结肠癌患者的预后价值仍未知。本研究旨在探讨PNI对Ⅲ期结肠癌患者的预后价值。方法本文回顾了2007年12月至2013年12月期间,274例接受根治性肿瘤切除术后接受奥沙利铂和卡培他滨辅助化疗的Ⅲ期结肠癌的连续患者的医疗记录。采用受试者工作特征(receiver operating characteristic,ROC)曲线分析确定最佳PNI临界值。采用卡方检验或Fisher’s精确检验评估PNI与全身炎症反应标志物[包括淋巴细胞与单核细胞比值(lymphocyte-to-monocyte ratio,LMR)、中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)、血小板与淋巴细胞比值(platelet-to-lymphocyte ratio,PLR)、C反应蛋白(C-reactive protein,CRP)水平]和临床病理特征的相关性。采用Spearman’s相关系数进行相关分析。采用Kaplan-Meier法和log-rank检验分析PNI分层的无病生存期(disease-free survival,DFS)和总生存期(overall survival,OS),并通过Cox回归分析确定预后因子。结果术前PNI与LMR呈正相关(r=0.483,P <0.001),与NLR(r=-0.441,P <0.001)、PLR(r=-0.607,P <0.001)和CRP水平(r=-0.333,P <0.001)呈负相关。在ⅢC期结肠癌患者中,低PNI(≤49.22)与短OS和DFS显著相关,而在ⅢA/ⅢB期结肠癌患者中则不相关。此外,在PNI低的患者中,接受6–8个疗程辅助化疗的患者比接受<6个疗程治疗的患者获得了更长的OS和DFS。多变量分析显示PNI与DFS独立相关(风险比=2.001;95%置信区间:1.157–3.462;P=0.013)。结论术前PNI是接受根治性肿瘤切除术后辅助化疗的Ⅲ期结肠癌患者生存结局的重要预测指标。 | Jianhong Peng Rongxin Zhang Yixin Zhao Xiaojun Wu Gong Chen Desen Wan Zhenhai Lu Zhizhong Pan | 2019 | 癌症2019，38，1： | 10 |
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