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| 1 | 用碳化养护电弧熔炉钢渣制备集料和混凝土显示文摘将电弧熔炉(electricarc furnace,EAF)钢渣和石灰混和制成球状集料,置于密闭容器当中,并通入100%的CO2气体进行碳化,在0.5066MPa保持2h。通过质量法测定添加质量分数为11.94%石灰的EAF钢渣(下同)集料CO2的吸收率为5%,通过红外光谱(infrared,IR)分析测定CO2的吸收率为13.88%。用碳化的钢渣集料制备混凝土再进行碳化养护,同时利用碎石和河砂为集料制备碳化混凝土作为参比样。用质量法测定2种混凝土的碳化率分别为21.14%和10.57%;用IR法的为13.81%和16.97%。碳化后电弧熔炉钢渣集料内生长着大量簇生的犬牙状碳酸钙晶体。 | 常钧 WANG Sanwu SHAO Yixin | 2007 | 硅酸盐学报2007,35,9: | 31 |
| 2 | Holocene high lake-levels and pan-lake period on Badain Jaran Desert显示文摘Many lakes exist in southeastern Badain Jaran Desert and its hinterland, including 110 perennial lakes and some seasonal or extinct lakes. Geomorphological, sedimentological, and bioglyph evidence obtained from field investigations on Badain Jaran Desert lake group, alongside measurements and dating performed on lake relic, prove that these lakes expanded while the climate was relatively wet during early and middle Holocene. The dating results suggest that the pan-lake period of the Badain Jaran Desert began at 10 cal kyr BP, before which the limnic peat period occurred(11–10 cal kyr BP). Many lakes reached their maximal water-level during 8.6–6.3 cal kyr BP and retreated or dried up in the late Holocene(about 3.5–0 cal kyr BP). During that period, the precipitation at Badain Jaran Desert may have reached 200 mm yr^(-1) for 7.7–5.3 cal kyr BP, inferred from both the age and precipitation rate of calcareous root tubes. The water balance calculation shows that wetter and warmer climate and the increase of underground water recharge were key factors in maintaining and developing the lake group at both centennial and millennial time scales. Furthermore, lake surface expansion and the increasing fresh water availability set the background for the prosperous prehistoric culture. | WANG NaiAng NING Kai LI ZhuoLun WANG YiXin JIA Peng MA Ling | 2016 | Science China Earth Sciences2016,59,8: | 19 |
| 3 | Photochemical pollution in Lanzhou, China - A case study显示文摘The photochemical air pollution in Xigu district of Lanshou city, Gansu Province was studied during a period of 1981-1984. The extremely high NMHC/NOx ratio and ozone level elevation after rain have been noticed. A series of outdoor and indoor reaction chamber simulation experiments conducted in order to understand the specific conditions. The ozone formation under NMHC/NOx condition and the possible reason for high ozone concentration after rain are discussed. | Tang Xiaoyan , Li Jinglong, Dong ZhenXing, Wang Yuying,Wang Wenxing , Qi Liwen, Liu Xiling, Zhang Yutian, Zhang Xuejin,Tian Bingshen, Jin Suwen , Yang Lingqing and Zhang Yixin Department of Technical Physics,Peking University, Beijing, China. Chinese Reaearch Academy of Eavironmental Sciences, Beijing,China. Gansu Provincial Environmental Research Institute, Lanshou, China. Lanshou Petrochemical Engineering Institute, Lanshou, China. | 1989 | Journal of Environmental Sciences1989,1,1: | 15 |
| 4 | Security value based expansion planning of power system with integration of large-scale wind power显示文摘Concerning the integration of large-scale wind power,an integrated model of generation and transmission expansion planning is proposed based on the assessment of the value of steady state and dynamic security.In the assessment of security value,the unit commitment simulation based on the predicted hourly load and wind power output data in the planning horizon is used to evaluate the costs of preventive control,emergency control and social losses due to the uncertainty of load and wind power.The cost of preventive control consists of the fuel cost of power generation,the environmental cost and the load shedding cost.This not only provides a systematic method of security assessment of power system expansion planning schemes,but also broadens the perspective of power system planning from the technology and economic assessment to the measure of the whole social value.In the assessment process,the preventive control and emergency control of cascading failures are also presented,which provides a convincing tool for cascading failure analysis of planning schemes and makes the security assessment more comprehensive and reasonable.The proposed model and method have been demonstrated by the assessment of two power system planning schemes on the New England 10-genarator 39-bus System.The importance of considering the value of security and simulating hourly system operation for the planning horizon,in expansion planning of power system with integration of large-scale wind power,has been confirmed. | YU YIXin WANG JingRan LV XiaoYang | 2012 | Science China(Technological Sciences)2012,55,7: | 11 |
| 5 | Relation of hepatic EROD activity and cytochrome P4501A level in Sebastiscus marmoratus exposed to benzo[a]pyrene显示文摘这研究被设计调查 benzo 的体内效果[一]有细胞色素 P4501A ( CYP1A )蛋白质的活动和它的关联在 Sebastiscus marmoratus 铺平的肝的 ethoxyresorufin-O-deethylase (侵蚀)上的分核( BaP )通过水列暴露于 BaP , 10 , 100 , 1000 ng/L ,分别地)或与 BaP 的 intraperitoneal 注射被对待( 0.5 , 1 , 5 , 10 mg/kg ,分别地)每 7 d 。结果证明在到 1000 ng/L BaP 的水运的暴露的 25 d 以后,捞肝的 CYP1A 层次和侵蚀活动显著地被导致。相反,侵蚀活动没被改变在第二 intraperitoneal 注射以后的 7 d,而, CYP1A 蛋白质层次被增加。胆汁的 BaP 代谢物的剂量依赖者增加证明 CYP1A 的催化活动被处理与 BaP 导致。关于胆汁的 BaP 代谢物(100 ng/L ) 的最低可见效果集中与侵蚀活动(1000 ng/L ) 的参考是比那低得多的。结果建议那胆汁的多不的芳族烃(哼) 代谢物被显示更好反映污染坡度比侵蚀哼活动。它看起来必要测量 CYP1A 蛋白质层次在相关毒物学的评价补充 EROD 活动。 | WANG Yun ZHENG Ronghui ZUO Zhenghong CHEN Yixin WANG Chonggang | 2008 | Journal of Environmental Sciences2008,20,1: | 10 |
| 6 | A review of extractive distillation from an azeotropic phenomenon for dynamic control显示文摘Extractive distillation is an effective method for separating azeotropic or close boiling point mixtures by adding a third component.Various technologies for performing the extractive distillation process have been explored to protect the environment and save resources.This paper focuses on the improvement of these advanced technologies in recent years.Extractive distillation is retrieved and analyzed from the view of phase equilibrium,selection of solvent in extractive distillation,process design,energy conservation,and dynamic control.The quantitative structure–property relationship used in extractive distillation is discussed,and the future development of extractive distillation is proposed to determine how the solvent affects the relative volatility of the separated mixture.In the steady state design,the relationship between the curvature of the residue curve and parameters of the optimal steady state is also highlighted as another field worthy of further study to simplify the distillation process. | Yixin Ma Peizhe Cui Yongkun Wang Zhaoyou Zhu Yinglong Wang Jun Gao | 2019 | Chinese Journal of Chemical Engineering2019,27,7: | 9 |
| 7 | Radial propagation of magnetospheric substorm-injected energetic electrons observed using a BD-IES instrument and Van Allen Probes显示文摘In cases where substorm injections can be observed simultaneously by multiple spacecraft,they can help elucidate the potential mechanisms of particle transport and energization,of great importance to understanding and modeling the magnetosphere.In this paper,using data returned from the BeiDa-IES(BD-IES) instrument onboard a satellite in an inclined(55°) geosynchronous orbit(IGSO),in combination with two geo-transfer orbiting(GTO) satellite Van Allen Probes(A and B),we analyze a substorm injection event that occurred on the 16 th of October 2015.During this substorm injection,the IGSO onboard BD-IES was outbound,while both Van Allen Probe satellites(A and B) were inbound,a configuration of multiple trajectories that provides a unique opportunity to simultaneously investigate both the inward and outward radial propagation of substorm injection.Indicated by AE/AL indices,this substorm was closely related to an IMF/solar wind discontinuity that showed a sharp change in IMF Bz direction to the north.The innermost signature of this substorm injection was detected by Van Allen Probes A and B at L-3.7,while the outermost signature was observed by the onboard BD-IES instrument at L~\0.These data indicate that the substorm had a global,rather than just local,effect.Finally,we suggest that electric fields carried by fast-mode compressional waves around the substorm injection are the most likely candidate mechanism for the electron injection signatures observed in the inner- and outermost inner magnetosphere. | ZONG QiuGang HAO YiXin ZOU Hong FU SuiYan ZHOU XuZhi REN Jie WANG LingHua YUAN ChongJing LIU ZhiYang JIA XiangHong QUAN Lin LIU Ying WANG YongFu | 2016 | Science China Earth Sciences2016,59,7: | 8 |
| 8 | Variable load failure mechanism for high-speed load sensing electro-hydrostatic actuator pump of aircraft显示文摘This paper presents a novel transient lubrication model for the analysis of the variable load failure mechanism of high-speed pump used in Load Sensing Electro-Hydrostatic Actuator(LS-EHA). Focusing on the slipper/swashplate pair partial abrasion, which is considered as the dominant failure mode in the high-speed condition, slipper dynamic models are established. A forth sliding motion of the slipper on the swashplate surface is presented under the fact that the slipper center of mass will rotate around the center of piston ball when the swashplate angle is dynamically adjusted. Besides, extra inertial tilting moments will be produced for the slipper based on the theorem on translation of force, which will increase rapidly when LS-EHA pump operates under highspeed condition. Then, a dynamic lubricating model coupling with fluid film thickness field, temperature field and pressure field is proposed. The deformation effects caused by thermal deflection and hydrostatic pressure are considered. A numerical simulation model is established to validate the effectiveness and accuracy of the proposed model. Finally, based on the load spectrum of aircraft flight profile, the variable load conditions and the oil film characteristics are analyzed, and series of variable load rules of oil film thickness with variable speed/variable pressure/variable displacement are concluded. | Cun SHI Shaoping WANG Xingjian WANG Yixin ZHANG | 2018 | Chinese Journal of Aeronautics2018,31,5: | 8 |
| 9 | Dynamic tensile behaviour and crack propagation of coal under coupled static-dynamic loading显示文摘The fracture behaviour and crack propagation features of coal under coupled static-dynamic loading conditions are important when evaluating the dynamic failure of coal.In this study,coupled static-dynamic loading tests are conducted on Brazilian disc(BD)coal specimens using a modified split Hopkinson pressure bar(SHPB).The effects of the static axial pre-stress and loading rate on the dynamic tensile strength and crack propagation characteristics of BD coal specimens are studied.The average dynamic indirect tensile strength of coal specimens increases first and then decreases with the static axial pre-stress increasing.When no static axial pre-stress is applied,or the static axial pre-stress is 30%of the static tensile strength,the dynamic indirect tensile strength of coal specimens shows an increase trend as the loading rate increases.When the static axial pre-stress is 60%of the static tensile strength,the dynamic indirect tensile strength shows a fluctuant trend as the loading rate increases.According to the crack propagation process of coal specimens recorded by high-speed camera,the impact velocity influences the mode of crack propagation,while the static axial pre-stress influences the direction of crack propagation.The failure of coal specimens is a coupled tensile-shear failure under high impact velocity.When there is no static axial pre-stress,tensile cracks occur in the vertical loading direction.When the static axial pre-stress is applied,the number of cracks perpendicular to the loading direction decreases,and more cracks occur in the parallel loading direction. | Xianjie Hao Weisheng Du Yixin Zhao Zhuowen Sun Qian Zhang Shaohua Wang Haiqing Qiao | 2020 | International Journal of Mining Science and Technology2020,30,5: | 8 |
| 10 | Quantile residual lifetime for left-truncated and right-censored data显示文摘This article proposes a simple nonparametric estimator of quantile residual lifetime function under left-truncated and right-censored data. The asymptotic consistency and normality of this estimator are proved and the variance expression is calculated. Two bootstrap procedures are employed in the simulation study,where the latter bootstrap from Zeng and Lin(2008) is 4000 times faster than the former naive one, and the numerical results in both methods show that our estimating approach works well. A real data example is used to illustrate its application. | WANG YiXin LIU Peng ZHOU Yong | 2015 | Science China Mathematics2015,58,6: | 7 |
| 11 | Electrically driven chip cooling device using hybrid coolants of liquid metal and aqueous solution显示文摘Heat dissipation of electronic devices keeps as a tough issue for decades. As the most classical coolant in a convective heat transfer process, water has been widely adopted which however inherits with limited thermal conductivity and relies heavily on mechanical pump. As an alternative, the room temperature liquid metal was increasingly emerging as an important coolant to realize much stronger enhanced heat transfer. However, its thermal capacity is somewhat lower than that of water, which may restrict the overall cooling performance. In addition, the high cost by taking too much amount of liquid metal into the device also turns out to be a big concern for practical purpose. Here, through combining the individual merits from both the liquid metal with high conductivity and water with large heat capacity, we proposed and demonstrated a new conceptual cooling device that integrated hybrid coolants, radiator and annular channel together for chip thermal management. Particularly, the electrically induced actuation effect of liquid metal was introduced as the only flow driving strategy, which significantly simplified the whole system design. This enables the liquid metal sphere and its surrounding aqueous solution to be quickly accelerated to a large speed under only a very low electric voltage. Further experiments demonstrated that the cooling device could effectively maintain the temperature of a hotpot(3.15 W/cm^2) below 55oC with an extremely small power consumption rate(0.8 W). Several situations to simulate the practical working of the device were experimentally explored and a theoretical thermal resistance model was established to evaluate its heat transfer performance. The present work suggests an important way to make highly compact chip cooling device, which can be flexibly extended into a wide variety of engineering areas. | TAN SiCong ZHOU YiXin WANG Lei LIU Jing | 2016 | Science China(Technological Sciences)2016,59,2: | 7 |
| 12 | Development of Fully-Distributed Fiber Sensors Based on Brillouin Scattering显示文摘Brillouin scattering based optical fiber sensors(BOFS)have the unique advantages over other sensors such as long distance,fully distributed,and multi-parameter sensing.The progresses on the development of BOFS technology in Nanjing University are reviewed.The key technologies to make BOFS with ultra-long distance,high spatial resolution,and fast measuring speed are discussed and realized. | Xuping ZHANG Yuangang LU Feng WANG Hao LIANG Yixin ZHANG | 2011 | Photonic Sensors2011,1,1: | 7 |
| 13 | On direct optimization in mode space for robust supergain beamforming of circular array mounted on a cylinder显示文摘A direct robust supergain method in mode space for the circular array mounted on an infinite rigid cylinder was proposed,and then it was also applied to the circular array mounted on a finite rigid cylinder which is more practical.According to the concept of phase modes,the beam pattern is expanded into a series of eigen-beams multiplying by modal coefficients. The modal noise cross spectral matrix is calculated from sound scattering theory.In the original modal robust supergain method,the coefficient vector in mode space is transformed indirectly from the weighting vector in sensor space.The method presented here gives the most suitable modal coefficient vector directly under the related constraint conditions based on the second-order cone programming.The results of simulation show that the direct modal robust supergain method can not only improve robustness using the white noise gain constraint, but also change the mode orders to provide compromise between array gain and robustness in low frequencies.Beam performance measures such as sidelobe level can be optimized as well as array gain,so this method can give more effective schemes for designing practical robust supergain beamformers. | WANG Yong YANG Yixin LI Xuegang | 2012 | Chinese Journal of Acoustics2012,31,4: | 6 |
| 14 | Insight into the catalytic activity of MXenes for hydrogen evolution reaction显示文摘MXenes have exhibited great potential as cost-effective electrocatalysts for hydrogen evolution reaction(HER). However, insight into the origin of activity is still missing. Herein, on the basis of a systematical investigation of the HER performance of 20 MXenes(M_2NO_2 and M_2CO_2, M = Sc, Ti, V, Cr, Zr, Nb, Mo,Hf, Ta and W), a Fermi-abundance model is proposed to understand variation of the activity in different MXenes. It is found that the occupied p electronic states of surface O atoms play a decisive role in the HER activity of MXenes. More importantly, Ti_2NO_2 and Nb_2NO_2 are found to be promising HER electrocatalysts with the free energy for hydrogen adsorption close to zero. This work not only provides possible catalysts for HER, the developed Fermi-abundance model but also is applicable to other two-dimensional materials and may serve as a simple descriptor of the intrinsic HER activity. | Xiaowan Bai Chongyi Ling Li Shi Yixin Ouyang Qiang Li Jinlan Wang | 2018 | Science Bulletin2018,63,21: | 6 |
| 15 | QSPR modeling of azeotropic temperatures and compositions for binary azeotropes containing lower alcohols using a genetic function approximation显示文摘Binary azeotropes, which contain two chemicals with a relative volatility of 1, are very common in the chemical industry. Understanding azeotropes is essential for effectively separating binary azeotropes containing lower alcohols. Experimental techniques and ab initio approaches can produce accurate results;however, these two processes are time consuming and labor intensive. Although thermodynamic equations such as UNIFAC are widely used, experimental values are required, and it is difficult to choose the best groups to represent a complex system. Because of their high efficiency and fast calculation speed, quantitative structure–property relationship(QSPR) tools were used in this work to predict the azeotropic temperatures and compositions of binary azeotropes containing lower alcohols. The QSPR models for 64 binary azeotropes based on centroid approximation and weighted-contribution-factor approximation were established using the genetic function approximation(GFA) procedure in Materials Studio software, and a leave-one-out cross-validation procedure was conducted.External tests of an additional 16 azeotropes were also investigated, and high determination coefficient values were obtained. The best QSPR models were explained in terms of the molecular structure of the azeotropes,and good predictive ability was obtained within acceptable prediction error levels. | Yixin Ma Kang Ma Huixin Wang Xueli Geng Jun Gao Zhaoyou Zhu Yinglong Wang | 2019 | Chinese Journal of Chemical Engineering2019,27,4: | 6 |
| 16 | Effect of Mg/Al atom ratio of support on catalytic performance of Co-Mo/MgO-Al_2O_3 catalyst for water gas shift reaction显示文摘Co-Mo-based catalysts supported on mixed oxide supports MgO-Al2O3 with different Mg/Al atom ratios for water gas shift reaction were studied by means of TPR, Raman, XPS and ESR. It was found that the octahedral Mo species in oxidized Co-Mo/MgO(x)-Al2O3 catalyst and the contents of Mo5+, Mo4+, S2- and S22- species in the functioning catalysts increased with increasing the Mg/Al atom ratio of the support under the studied experimental conditions. This is favorable for the formation of the active Co-Mo-S phase of the catalysts. Catalytic performance testing results showed that the catalysts Co-Mo/MgO-Al2O3 with the Mg/Al atom ratio of the support in the range of 0.475-0.525 exhibited optimal catalytic activity for the reaction. | Yixin Lian Huifang Wang Quanxing Zheng Weiping Fang Yiquan Yang | 2009 | Journal of Natural Gas Chemistry2009,18,2: | 6 |
| 17 | Crocetin Potentiates Neurite Growth in Hippocampal Neurons and Facilitates Functional Recovery in Rats with Spinal Cord Injury显示文摘Crocetin is an ingredient of traditional Chinese medicine and has therapeutic potential in various diseases due to its pharmacological properties, such as neuroprotection, anti-oxidative stress, and anti-inflammation. These properties might benefit the treatment of spinal cord injury.In the present study, we tested the effect of crocetin on neurite growth and sensorimotor dysfunction in a rat model of spinal cord injury. We evaluated the viability of cultured hippocampal neurons with tetrazolium dye and lactate dehydrogenase assays, visualized neurites and axons with antibody staining, and monitored motor and sensorimotor functions in rats with spinal cord injury using the Basso,Beattie, and Bresnahan assay and the contact plantar placement test, respectively, and measured cytokine expression using enzyme-linked immuno-absorbent assays.We found that crocetin(1) did not alter the viability of cultured hippocampal neurons;(2) accelerated neurite growth with preference for the longest process in individual hippocampal neurons;(3) reversed the inhibition of neurite growth by chondroitin sulfate proteoglycan and Nogo A;(4) facilitated the recovery of motor and sensorimotor functions after spinal cord injury; and(5) did not inhibit pro-inflammatory responses, but restored the innervation of the descending 5-HT system in injured spinalcord. Crocetin promotes neurite growth and facilitates the recovery of motor and sensorimotor functions after spinal cord injury, likely through repairing neuronal connections. | Xiqian Wang Xiejia Jiao Zhonghao Liu Yixin Li | 2017 | Neuroscience Bulletin2017,33,6: | 6 |
| 18 | Effect of Bacillus amyloliquefaciens and Bacillus subtilis on fermentation, dynamics of bacterial community and their functional shifts of whole-plant corn silage显示文摘Background:Bacillus amyloliquefaciens(BA)and Bacillus subtilis(BS)are usually used as feed supplements directly or bacterial inoculants in biological feeds for animals.However,few research have reported the effects of BA and BS on fermentation characteristics and bacterial community successions of whole-plant corn silage during ensiling.If the BA and BS inoculants have positive effects on silages,then they could not only improve fermentation characteristics,but also deliver BA or BS viable cells to ruminants,which would play its probiotic effect.Therefore,the objectives of this study were to investigate the effects of BA and BS on the fermentation,chemical characteristics,bacterial community and their metabolic pathway of whole-plant corn silage.Results:Freshly chopped whole-plant corn was inoculated without or with BA and BS,respectively,and ensiled for1,3,7,14 and 60 d.Results showed that BA and BS inoculations increased lactic acid concentrations of whole-plant corn silages compared with control,and BA inoculation decreased acetic acid concentrations,whereas BS inoculation decreased fiber contents and increased crude protein(CP)content.Higher water-soluble carbohydrate contents and lower starch contents were observed in BA-and BS-inoculated silages compared with that in control.The decreased CP content and increased non-protein nitrogen content were observed in BA-inoculated silage,which was consistent with the higher amino acid metabolism abundances observed in BA-inoculated silage.In addition,it was noteworthy that BA and BS inoculations increased the metabolism of cofactors and vitamins,and decreased the relative abundances of drug resistance:antimicrobial pathways.We also found that the bacterial metabolism pathways were clearly separated into three clusters based on the ensiling times of whole-plant corn silage in the present study.There were no significant differences in bacterial community compositions among the three groups during ensiling.However,BA and BS inoculations decreased the relative abundances of undesirable bacteria such as Acetobacter and Acinetobacter.Conclusion:Our findings suggested that the BS strain was more suitable as silage inoculants than the BA strain in whole-plant corn silage in this study. | Jie Bai Marcia Franco Zitong Ding Lin Hao Wencan Ke Musen Wang Dongmei Xie Ziqian Li Yixin Zhang Lin Ai Xusheng Guo | 2022 | Journal of Animal Science and Biotechnology2022,13,3: | 5 |
| 19 | Advances and prospects of PVDF based polymer electrolytes显示文摘Exploring highly foldable batteries with no safety hazard is a crucial task for the realization of portable,wearable,and implantable electric devices.Given these concerns,developing solid-state batteries is one of the most promising routes to achieve this aspiration.Because of the excellent flexibility and processability,polyvinylidene fluoride(PVDF) based electrolytes possess great potential to pack high energy density flexible batteries,however,suffers the various intrinsic shortcomings such as inferior ionic conductivity,a high degree of crystallinity,and lack of reactive groups.Clearing the progress of the present state and concluding the specific challenges faced by PVDF based electrolytes will help to develop PVDF based polymer batteries.In this review,we summarize the recent progress of gel polymer electrolytes and all solid polymer electrolytes based on PVDF.The ion transport mechanisms and preparation methods of PVDF based electrolytes are briefly introduced.Meanwhile,the current design principle and properties of electrolytes are highlighted and systematically discussed.Some peculiar modified strategies performed in lithium-sulfur batteries and lithium-oxygen batteries are also included.Finally,this review describes the challenges and prospects of some solid-state electrolytes to provide strategies for manufacturing high-performance PVDF electrolytes aimed at practical application with flexible requirements. | Yixin Wu Yu Li Yang Wang Qian Liu Qingguo Chen Minghua Chen | 2022 | Journal of Energy Chemistry2022,31,1: | 5 |
| 20 | Non-suicidal self-harm is linked to suicidal thoughts in Chinese adolescents with mood disorders:a cross-sectional report显示文摘Non-suicidal self-injury (NS SI) refers to any intentional,self-inflicted behavior that causes direct damage to body tissues (Kerr et al.,2010),and has emerged as a challenging public health issue worldwide,especially among adolescents.The most common presentations of NSSI include skin-cutting,severe scratching,and burning (Whitlock et al,2006). | Yixin WANG Jianbo LAI Chanchan HU Hongbo MENG Duo LYU Shaohua HU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021,22,3: | 5 |