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| 1 | Bone marrow mesenchymal stem cell transplantation for treatment of spinal cord injury An in vivo magnetic resonance imaging tracking study显示文摘Non-invasive tracing in vivo can be used to observe the migration and distribution of grafted stem cells,and can provide experimental evidence for treatment.This study utilized adenovirus-carrying enhanced green fluorescent protein(AD5/F35-eGFP) and superparamagnetic iron oxide(SPIO)-labeled bone marrow mesenchymal stem cells(BMSCs).BMSCs,double-labeled by AD5/F35-eGFP and SPIO,were transplanted into rats with spinal cord injury via the subarachnoid space.MRI tracing results demonstrated that BMSCs migrated to the injured spinal cord over time(T2 hypointensity signals).This result was verified by immunofluorescence.These results indicate that MRI can be utilized to trace in vivo the SPIO-labeled BMSCs after grafting. | Yu Liu Boai Zhang Yi Song Yubin Deng Yanjie Jia Qiyong Gong | 2011 | Neural Regeneration Research2011，6，13： | 14 |
| 2 | NLRP3-dependent pyroptosis is required for HIV-1 gp120- induced neuropathology显示文摘The human immunodeficiency virus-1(HIV-1)envelope protein gp120 is the major contributor to the pathogenesis of HIVassociated neurocognitive disorder(HAND).Neuroinflammation plays a pivotal role in gp120-induced neuropathology,but how gp120 triggers neuroinflammatory processes and subsequent neuronal death remains unknown.Here,we provide evidence that NLRP3 is required for gp120-induced neuroinflammation and neuropathy.Our results showed that gp120-induced NLRP3-dependent pyroptosis and IL-1βproduction in microglia.Inhibition of microglial NLRP3 inflammasome activation alleviated gp120-mediated neuroinflammatory factor release and neuronal injury.Importantly,we showed that chronic administration of MCC950,a novel selective NLRP3 inhibitor,to gp120 transgenic mice not only attenuated neuroinflammation and neuronal death but also promoted neuronal regeneration and restored the impaired neurocognitive function.In conclusion,our data revealed that the NLRP3 inflammasome is important for gp120-induced neuroinflammation and neuropathology and suggest that NLRP3 is a potential novel target for the treatment of HAND. | Xiaolong He Weijun Yang Zhijie Zeng Yi Wei Jie Gao Bao Zhang Li Li Liqun Liu Yu Wan Qing Zeng Zelong Gong Liting Liu Hanyun Zhang Yubin Li Shaojie Yang Tongtong Hu Lixian Wu Eliezer Masliah Shenghe Huang Hong Cao | 2020 | Cellular & Molecular Immunology2020，17，3： | 11 |
| 3 | Study on W-band Sheet Electron Beam Sine Waveguide Traveling-Wave Tube显示文摘 | XU Xiong WEI Yanyu SHEN Fei GONG Yubin YUE Lingna TANG Tao ZHAO Guoqing WANG Wenxiang | 2012 | Chinese Journal of Electronics2012，21，1： | 3 |
| 4 | Comparison of robot‐assisted and laparoscopic partial nephrectomy for complex renal tumours with a RENAL nephrometry score ≥7: peri‐operative and oncological outcomes显示文摘 | Yubin Wang Xin Ma Qingbo Huang Qingshan Du Huijie Gong Jiwen Shang Xu Zhang | 2016 | BJU Int2016，，： | 2 |
| 5 | Study of high power Ka-band rectangular double-grating sheet beam BWO显示文摘 | Zhang Yabin Gong Yubin Wang Zhanliang | 2014 | IEEE Trans on Plasma Sci2014，42，6： | 1 |
| 6 | Study of traveling wave tube with folded-waveguide circuit shielded by photonic crystals显示文摘 | Gong Yubin Yin Hairong Wei Yanyu | 2010 | IEEE Trans on Electron Devices2010，57，5： | 1 |
| 7 | Analysis of rectangular waveguide grating slow-wave structure with the arbitrary shaped grooves显示文摘 | Lu Zhigang Gong Yubin Wei Yanyu | 2006 | Journal of Infrared Millimeter and Terahertz Waves2006，27，6： | 1 |
| 8 | Suppression of in-band power holes in helix traveling-wave tubes显示文摘 | Gong Yubin Duan Zhaoyun Wang Wenxiang | 2011 | IEEE Trans on Electron Devices2011，58，5： | 1 |
| 9 | Analysis of Coaxial Ridged Disk-Loaded Slow-Wave Structures for Relativistic Traveling Wave Tubes显示文摘 | Yue Lingna Wang Wenxiang Gong Yubin | 2004 | IEEE Trans on Plasma Science2004，32，3： | 1 |
| 10 | Study on the radial sheet beam electron optical system显示文摘 | Wang Shaomeng Gong Yubin Wei Yanyu | 2012 | IEEE Trans on Plasma Sci- ence2012，40，12： | 1 |
| 11 | The conditions for stable sheet electron beams transport in periodic permanent magnet fields显示文摘 | Wang Zhanliang Gong Yubin Wei Yanyu | 2010 | Journal of Infrared Millimeter and Terahertz Waves2010，31，6： | 1 |
| 12 | Mode Discriminator Based on Mode-Selective Coupling 显示文摘 | Wang Wenxiang Gong Yubin Yu Guofen | 2003 | IEEE Trans on MTT2003，51，1： | 1 |
| 13 | Mode discriminator based on mode-selective coupling显示文摘 | Wang Wenxiang Gong Yubin Yu Guofen | 2003 | IEEE Trans on MicrowaveTheory and Techniques2003，51，1： | 1 |
| 14 | Dispersion relation of Π—line slow wave structure显示文摘 | Yubin Gong Wenxiang Wang | 1997 | International Journal of Infrared and Millimeter Waves1997，，3： | 1 |
| 15 | Study of traveling wave tube with folded-waveguide circuit shielded by photonic crystals显示文摘 | Gong Yubin Yin Hairong Wei Yanyu | 2010 | IEEE Trans on Electron Devices2010，57，5： | 1 |
| 16 | Investigation on a W Band Ridge-Loaded Folded Waveguide TWT显示文摘 | He Jun Wei Yanyu Gong Yubin | | 0，，08： | 1 |
| 17 | A Rectangular Groove-Loaded Folded Waveguide for Millimeter-Wave Traveling-Wave Tubes显示文摘 | Liao Mingliang Wei Yanyu Gong Yubin | | 0，，07： | 1 |
| 18 | A novel V-shaped mi- crostrip meander-line slow-wave structure for W-band MMPM 显示文摘 | Shen Fei Wei Yanyu Gong Yubin | 2012 | IEEE Plasma Science2012，40，2： | 1 |
| 19 | Mode discriminator based on mode selective coupling显示文摘 | Wang Wengxiang Gong Yubin | 2003 | IEEE Trans on Microwave Theory and Tech niques2003，51，1： | 1 |
| 20 | THz trapped ion model and THz spectroscopy detection of potassium channels显示文摘Advanced molecular dynamics(MD)simulation and infrared(IR)spectroscopy have been widely adopted to reveal the detailed dynamic process of high-speed selective permeability of potassium channels.Yet these MD simulations cannot avoid the choice of empirical molecular force fields and high transmembrane voltages(as driving electric fields for ions)far exceeding physiological levels.Moreover,the IR spectroscopy method usually requires isotope labels for carbonyl groups of the channels,which may change the original permeation process.Here,we build the terahertz(THz)trapped ion model for the selectivity filter(SF)of potassium channels KcsA based on the density functional theory(DFT)calculation of ion potentials.In this model,the zero-point energy of trapped ions and quantum tunneling effect provide the physical basis for near diffusion limited permeation rates of ions and explain the high driving electric field in MD simulations.Quantitative calculations of zero-point energy and tunneling probability show that the quantum effect assisted knock-on mechanism may help to realize the physiological functions of potassium channels.Furthermore,based on the trapped ion model,we calculated the ion decoherence timescale under the influence of protein environmental noise.We use the quantum optics method to describe the interaction between THz waves and the trapped ion.Then the novel THz spectroscopy approaches through the THz resonance fluorescence and the intense field non-resonant effect are presented theoretically.These are expected to be isotope label-free detective methods of the rapid ion permeation dynamics. | Kaicheng Wang Shaomeng Wang Lixia Yang Zhe Wu Baoqing Zeng Yubin Gong | 2022 | Nano Research2022，15，4： | 1 |
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