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| 1 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 2 | Biosorption of cadmium by various types of dried sludge: an equilibrium study and investigation of mechanisms显示文摘 | CHOI S B YUN Y S | 2006 | J Hazard Materi2006，138，2： | 1 |
| 3 | Chemical modification and immobilization of Corynebacterium glutamicum for biosorp- tion of Reactive black 5 from aqueous solution显示文摘 | Vijayaraghavan K Yun Y S | 2007 | Indus- trial & Engineering Chemistry Research2007，46，2： | 1 |
| 4 | Genetic algorithm with fuzzy logic controller for preemptive and non-preemptive joh-shop scheduling problems显示文摘 | YUN Y S | 2002 | Computers & Industry Engineering2002，43，3： | 1 |
| 5 | Geochemical behavior of rare earth elements during the evolution of CO2-rich groundwater: A study from the Kangwon district, South Korea 显示文摘 | CHOI H S YUN S T KOH Y K | 2009 | Chemical Geology2009，262，： | 1 |
| 6 | Kinetics of the reduction of hexavalent chromium with the brown seaweed Eckloniabiomass 显示文摘 | Park D Yun Y S Ahn C K | 2007 | Chemosphere2007，66，5： | 1 |
| 7 | Reverse V osteotomy of the distal humerus for the correction of cubitus varus 显示文摘 | YUN Y H SHIN S J MOON J G | 2007 | Bone Joint Surg Br2007，89，4： | 1 |
| 8 | Clinical and imaging assessment of cervical lymph node metastasis in papillary thyroid carcinomas显示文摘 | CHOI Y J YUN J S KOOK S H | 2010 | World J Surg2010，34，： | 1 |
| 9 | Effects of salinity on germina- tion of six forage species and their recovery from saline conditions显示文摘 | Yu Y S Yun L S Guo Y | 2003 | New Zealand Journal of Agricultural Re- search2003，46，： | 1 |
| 10 | Cell performance of MEAfabricated with Pt-ZSM-5-carbon electrode for PEMFC显示文摘 | Yun Y H Kim S D Park S W | 2010 | Microporous and Mesoporous Materials2010，131，13： | 1 |
| 11 | Blocked force measurement of electro-active paper actuator by micro-balance显示文摘 | KIM J KANG Y YUN S | 2007 | Sensors and Actuators A: Physical2007，133，2： | 1 |
| 12 | Anti-diabetic effects of CCCA, CMESS, and cordycepin from Cordyceps railitaris and the immune responses in streptozotocin-induced diabetic mice显示文摘 | YUN Y HAN S LEE S | 2003 | Natural Product Research2003，，9： | 1 |
| 13 | Cloning and expression of a novel gene encoding a new antibacterial peptide from silkworm,Bombyx mori显示文摘 | Kim S H Park B S Yun E Y | 1998 | Biochem Bioph Res Co1998，246，2： | 1 |
| 14 | Molecular characteriza- tion of gonadotropin suhunits and gonadotropin receptors in black porgy, Acanthopagrus schlegeli: effects of estra- diol-17beta on mRNA expression profiles显示文摘 | An K W Lee K Y Yun S G | 2009 | Comp Bio- chem Physiol B Biochem Mol Biol2009，152，2： | 1 |
| 15 | Synthesis and Characterization of New Blue- light-emitting Polymers Based on PPP and PPV having Fluorene Pendant at Vinyl Bridge显示文摘 | KIM Y H YUN J S etal | 2006 | J of Polym Sci: Part A: Polym Chem2006，44，16： | 1 |
| 16 | Elastic behavior of coals studied by mercury porosimetry显示文摘 | Suuberg E M Deevi S C Yun Y | 1995 | Fuel1995，74，： | 1 |
| 17 | Thionation of segetalins A and B, cyclic peptides with estrogen- like activity from seeds of Vaccaria segetalis 显示文摘 | Morita H Yun Y S Takeya K | 1997 | Bioorganic b-Medicinal Chemistry1997，5，3： | 1 |
| 18 | The Interaction Between Housing Investment and Economic Growth in China显示文摘 | Lin H Y Yun W P Zheng S Q | 2002 | International Real Estate Review2002，5，1： | 1 |
| 19 | Molecular characterization of PL97 - 1, the first Korean isolate of the porcine reproductive and respiratory syndrome virus 显示文摘 | KANG S Y YUN S I PARK H S | 2004 | Virus Research2004，104，： | 1 |
| 20 | New tricyclic sesquiterpenes from the fermentation broth of Stereum hirsutum显示文摘 | YUN B S LEE I K CHO Y | 2002 | Journal of Natural Products2002，65，5： | 1 |
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