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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Recent advances of laser-spectroscopy based techniques for applications in breath analysis 显示文摘 | Matthew R M Yury B Gerard W | 2007 | J Breath Res2007，1，1： | 1 |
| 3 | 显示文摘 | Tatiana S Yury A Vladimir B | 2010 | Journal of Crystal Growth2010，318，： | 1 |
| 4 | 显示文摘 | Tarasov B Yuri A Dobrovolskii | 2009 | Appl Catal A:General2009，12，： | 1 |
| 5 | Phylogenetic analysis of partial S1 and N gene sequences of infectious bronchitis virus isolates from Italy revealed genetic diversity and recombination显示文摘 | YURY A B GIOVANNI T PAOLA M | 2007 | Virus Genes2007，35，： | 1 |
| 6 | Cooperative luminescence and absorption in ytterbium-doped silica fiber and the fiber nonlinear transmission coefficient at λ=980 nm with a regard to the Ytterbium ions-pairs'effect显示文摘 | Alexander V K Yuri O B Itzel L M | 2006 | Optics Express2006，14，9： | 1 |
| 7 | Surface Structure of Stainless and Hadfield Steel after Impact Wear显示文摘 | Yuri N P Valentin G G Hans B | 2006 | Wear2006，260，6： | 1 |
| 8 | Reusable launch vehicle control in mul- tiple-time scale sliding modes 显示文摘 | Yuri B S Charles E H | 2000 | Journal of Guidance Control and Dynamics2000，23，6： | 1 |
| 9 | Sliding mode disturbance observer-based control for a reusable launch vehicle 显示文摘 | Charles E H Yuri B S | 2006 | Journal of Guidance Control and Dynamics2006，29，6： | 1 |
| 10 | MCI-186 (edaravone),a free radical scavenger,attenuates ischemiareperfusion injury and activation of phospholipase A2 in an isolated rat lung model after 18 h of cold preservation 显示文摘 | Yury A Reyes B Shimoyama T | 2006 | Eur J Cardiothorac Surg2006，29，3： | 1 |
| 11 | Association and structure of thermosensitive comblike block copolyrners in aqueous solutions显示文摘 | Cheng Gang Hua Fengiun Yuri B | 2008 | Macromolecules2008，41，13： | 1 |
| 12 | Oxidation of H2S on activated carbon KAU and influence of the surface state显示文摘 | Dmitrii V B Yuri P Z Irina V B | 2007 | Appl Catal B: Environ2007，70，14： | 1 |
| 13 | Quasistatic Seismic Damage Indicators for RC Structures from Dissipating Energies in Tangential Subspaces 显示文摘 | Wilfried B Kr?tzig Yuri S Petryna | 2014 | Mathematical Problems in Engineering2014，2014，615792： | 1 |
| 14 | Structure and conductivity of the crystalline polymer electrolyte β-PEO6 : LiAsF6显示文摘 | Edward S Yuri G A Peter G B | 2005 | J Am Chem Soc2005，127，12： | 1 |
| 15 | Reusable launch vehicle control in multiple-time scale sliding modes 显示文摘 | Yuri B S Charles E H | 2000 | Journal of Guidance Control and Dynamics2000，23，6： | 1 |
| 16 | Modeling rotorcraft dynamics with finite element multibody procedures显示文摘 | OLIVIER A B CARLO L B YURI G N | 2001 | Mathematical and Computer Modeling2001，33，： | 1 |
| 17 | Effective length of short Fabry-Perot cavityformed by uniform fiber Bragg gratings显示文摘 | YURI 0 B | 2006 | Optics Express2006，14，14： | 1 |
| 18 | Use of 16S rRNA, 23S rRNA, and gyrB gene sequence analysis to determine phylogenetic relationships of Bacillus cereus group microorganisms显示文摘 | SERGEI G B YURI P L VLADIMIR Z | 2004 | J Clinical Microbiology2004，42，8： | 1 |
| 19 | Sliding mode disturbance observer-based control for a reusable launch vehicle 显示文摘 | Charles E H Yuri B S | 2006 | Journal of Guidance Control and Dynamics2006，29，6： | 1 |
| 20 | Electron-beam Instability in left-handed media显示文摘 | YURY P B SERGEY S FRANCO N | 2008 | Physical Review Letters2008，100，24： | 1 |
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