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| 1 | Brain iron overload following intracranial haemorrhage显示文摘Intracranial haemorrhages,including intracerebral haemorrhage(ICH),intraventricular haemorrhage(IVH)and subarachnoid haemorrhage(SAH),are leading causes of morbidity and mortality worldwide.In addition,haemorrhage contributes to tissue damage in traumatic brain injury(TBI).To date,efforts to treat the long-term consequences of cerebral haemorrhage have been unsatisfactory.Incident rates and mortality have not showed significant improvement in recent years.In terms of secondary damage following haemorrhage,it is becoming increasingly apparent that blood components are of integral importance,with haemoglobin-derived iron playing a major role.However,the damage caused by iron is complex and varied,and therefore,increased investigation into the mechanisms by which iron causes brain injury is required.As ICH,IVH,SAH and TBI are related,this review will discuss the role of iron in each,so that similarities in injury pathologies can be more easily identified.It summarises important components of normal brain iron homeostasis and analyses the existing evidence on iron-related brain injury mechanisms.It further discusses treatment options of particular promise. | Thomas Garton Richard F Keep Ya Hua Guohua Xi | 2016 | Stroke & Vascular Neurology2016，1，4： | 11 |
| 2 | Role of lipocalin 2 in intraventricular haemoglobin-induced brain injury显示文摘Objective:Our recent studies have shown that blood components,including haemoglobin and iron,contribute to hydrocephalus development and brain injury after intraventricular haemorrhage(IVH).The current study investigated the role of lipocalin 2(LCN2),a protein involved in iron handling,in the ventricular dilation and neuroinflammation caused by brain injury in a mouse model of IVH.Design:Female wild-type(WT)C57BL/6 mice and LCN2-deficient(LCN2^(−/−))mice had an intraventricular injection of haemoglobin,and control mice received an equivalent amount of saline.MRI was performed presurgery and postsurgery to measure ventricular volume and the brains were used for either immunohistochemistry or western blot.Results:Ventricular dilation was observed in WT mice at 24 h after haemoglobin(25 mg/mL,20µL)injection(12.5±2.4 vs 8.6±1.5 mm^(3) in the control,p<0.01).Western blotting showed that LCN2 was significantly upregulated in the periventricular area(p<0.01).LCN2 was mainly expressed in astrocytes,whereas the LCN2 receptor was detected in astrocytes,microglia/macrophages and neurons.Haemoglobin-induced ventricle dilation and glia activation were less in LCN2^(−/−)mice(p<0.01).Injection of high-dose haemoglobin(50 mg/mL)resulted in lower mortality in LCN2^(−/−)mice(27%vs 86%in WT;p<0.05).Conclusions:Intraventricular haemoglobin caused LCN2 upregulation and ventricular dilation.Haemoglobin resulted in lower mortality and less ventricular dilation in LCN2^(−/−)mice.These results suggest that LCN2 has a role in haemoglobin-induced brain injury and may be a therapeutic target for IVH. | Hajime Shishido Yasunori Toyota Ya Hua Richard F Keep Guohua Xi | 2016 | Stroke & Vascular Neurology2016，1，2： | 3 |
| 3 | Scattering of SH waves by an elastic thin-walled rigidly supported inclusin 显示文摘 | Emets V F Kunets Ya I Matus V V | 2004 | Archive of Applied Mechanics2004，73，1112： | 1 |
| 4 | Early monitoring of serum cardiac troponin I for assessment of coronary reperfusion following thrombolytic therapy显示文摘 | Appie F Henry T Landt YA | 1996 | Am J Clin Pathol1996，105，1： | 1 |
| 5 | Initial complaints in frontotemporal lobar degeneration显示文摘 | Pijnenburg YA Gillissen F Jonker C | 2004 | Dement Geriatr Cogn Disord2004，17，： | 1 |
| 6 | Interaction of time-harmonic SH waves with a crack-like inclusion: edge region analysis 显示文摘 | Emets V F Kit H S Kunets Ya I | 1998 | International Journal of Fracture1998，94，： | 1 |
| 7 | Anatomy of the superficial temporal artery and its branches:its importance for surgery显示文摘 | Pinar YA Govsa F | 2006 | Surg Radiol Anat2006，28，3： | 1 |
| 8 | Heat- absorbing properties of explosion - suppressing powders显示文摘 | Datsenko D F Zabuga V Ya Dolinskaya L P | 1982 | Zhurnal Prildadnoi Khimii1982，55，3： | 1 |
| 9 | Behavioral tests after intracerebral hemorrhage in the rat显示文摘 | Ya Hua Timothy Schallert Richard F Keep | | 0，，： | 1 |
| 10 | Growth of ZnO nanorods by aqueous solution method with eleetrodeposited ZnO seed layers 显示文摘 | Liu Z F E L Ya J | 2009 | Appl Surf Sci2009，255，12： | 1 |
| 11 | Supercritical fluid-assisted preparation of imprinted contact lenses for drug delivery显示文摘 | Ya?ez F Martikainen L Braga ME | | 0，，03： | 1 |
| 12 | Microbial keratitis following penetrating keratoplasty 显示文摘 | Akova YA Onat M Koc F | 1999 | Ophthalmic Surg Lasers1999，30，6： | 1 |
| 13 | Analysis of homo- tropic and heterotropic cooperativity of diazepam ox- idation by CYP3A4 using site-directed mutagenesis and kinetic modeling显示文摘 | He YA Roussel F Halpert JR | 2003 | Arch Biochem Biophys2003，409，1： | 1 |
| 14 | Anatomy of the superficial temporal artery and its branches:its importance for surgery显示文摘 | Pinar YA Govsa F | 2006 | Surg Radiol Anat2006，28，3： | 1 |
| 15 | Initial complaints in frontotemporal lobar degeneration显示文摘 | Pijnenburg YA Gillissen F Jonker C | | 0，，： | 1 |
| 16 | Scattering of SH waves by an elastic thin-walled rigidly supported inclusion 显示文摘 | Emets V F Kunets Ya I Matus V V | 2004 | Archive of Applied Mechanics2004，73，1112： | 1 |
| 17 | Intracerebral hemorihage effects of aging on brain edema and heurological defit~its显示文摘 | Ye Gong Ya Hua Richard F | 2004 | Stroke2004，35，： | 1 |
| 18 | Validity of diagnostic criteria for chronic inflammatory demyelinating polyneuropathy:a multicentre European study显示文摘 | Rajabally YA Nicolas G Piéret F | 2009 | J Neurol Neurosurg Psychiatry2009，80，12： | 1 |
| 19 | Sildenafil citrate(viagra) induces cardioprotective effects after ischemiafreperfusion injury in infant rabbits显示文摘 | Bremer YA Salloum F Ockaili R | 2005 | Pediatric Res2005，57，1： | 1 |
| 20 | Present status of nmaway electron genera- tion in pressurized gases during nanosecond discharges显示文摘 | Levko D Krasik Ya E Tarasenko V F | 2012 | International Review of Physics2012，6，2： | 1 |
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