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| 1 | Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing显示文摘Hepatocellular 癌(HCC ) 是癌症实质词法,基因并且 phenotypic 差异。然而,我们不理解在 intratumor 异质和肿瘤的联系词法 / 组织学的特征之间的关系。用介绍 96 个肿瘤房间(30-36 各个) 和 15 个正常的肝房间(5 各个) 的单个房间的整个染色体的定序,与联系 HBV 的 HCC 从三个男病人收集了,我们证实拷贝数字变化在 hepatocarcinogenesis 早发生,但是此后在整个肿瘤仍然保持相对稳定前进。重要地,我们证明特定的 HCC 能具有 monoclonal 或 polyclonal 起源。有汇合的 multinodular 形态学的肿瘤是典型 polyclonal 肿瘤并且显示最高的 intratumor 异质。除了 mutational 和拷贝数字侧面,我们把了用导出 HBV 的外国 genomic 标记的 HCC 的同种细胞的起源。在 monoclonal HCC,所有肿瘤单身者房间展出一样的 HBV 集成,显示 HBV 集成是一个早司机事件并且在肿瘤前进期间仍然保持极其稳定。另外,我们的结果显示那两个都转移,迟了的传播并且早播种当模特儿,在 HCC 有一个角色前进。尤其是,开始的克隆传播的早 intrahepatic 导致同步 multifocal 肿瘤的形成。同时,我们在 HCC 识别了潜在的司机基因 ZNF717,它展出变化的高频率在单个房间并且人口铺平,,通过调整 IL-6/STAT3 小径行动的肿瘤 suppressor。这些调查结果热点多重不同肿瘤在 HCC 的进化机制,它为特定的处理策略建议需要。 | Meng Duan, Shu Zhang, Zhichao Wang, Jieyi Shi, Longzi Liu, Xiaoying Wang, Aiwu Ke, Jian Zhou, Jia Fan, Qiang Gao Junfeng Hao, Chong Li Sijia Cui Daniel L Worthley Ya Cao Ruibin Xi Xiaoming Zhang Jian Zhou, Jia Fan Qiang Gao | 2018 | Cell Research2018，28，3： | 21 |
| 2 | Change in cholesterol absorption and synthesis markers in patients with coronary heart disease after combination therapy with simvastatin plus ezetimibe显示文摘 | ZHANG Tao WU Wen-feng LIU Yang WANG Qi-hui WANG Lü-ya MI Shu-hua | 2013 | Chinese Medical Journal2013，，9： | 16 |
| 3 | Separation of chalcopyrite and pyrite from a copper tailing by ammonium humate显示文摘Copper tailings constitute a large proportion of mine wastes. Some of the copper tailings can be recycled to recover valuable minerals. In this paper, a copper tailing was studied through the chemical analysis method, Xray diffraction and scanning electron microscope-energy dispersive spectrum. It turned out that chalcopyrite(Cu) and pyrite(S) were the main recoverable minerals in the tailing. In order to separate chalcopyrite from pyrite in low pulp pH, ammonium humate(AH) was singled out as the effective regulator. The depression mechanism of AH on the flotation of pyrite was proved by FTIR spectrum and XPS spectrum, demonstrating that there was a chemical adsorption between AH and pyrite. By Response Surface Methodology(RSM), the interaction between AH, pulp pH and iso-butyl ethionine(Z200) was discussed. It was illustrated that the optimal dosage of AH was 1678 g·t^(-1) involving both the recovery of Cu and S. The point prediction by RSM and the closed-circuit flotation displayed that the qualified Cu concentrate and S concentrate could be obtained from the copper tailing.The study indicated that AH was a promising pyrite depressor in the low pulp pH from copper tailings. | Cuicui Lü Yongliang Wang Peng Qian Ya Liu Guoyan Fu Jian Ding Shufeng Ye Yuanfa Chen | 2018 | Chinese Journal of Chemical Engineering2018，26，9： | 5 |
| 4 | Determination of Cordycepin in Cordyceps kyushuensis by Capillary Electrophoresis and its Antitumour Activity显示文摘A simple, rapid and low-cost method of determination for cordycepin in Cordyceps kyushuensis by capillary zone electrophoresis (CZE) was developed. Based on the finding that there is a high concentration of cordycepin in both natural and cultured Cordyceps kyushuensis, the in vitro antitumor activity of cordycepin and the water extracts of Cordyceps kyushuensis has been investigated. This is the first report about the antitumor effect of Cordyceps kyushuensis. | Ying Jie SUN, Jian Ya LING, Peng L Han Xing ZHANG, Chang Kai ZHANG* State Key Laboratory of Microbial Technology, Life Science School of Shandong University, Jinan 250100 | 2003 | Chinese Chemical Letters2003，14，7： | 2 |
| 5 | Numerical simulation of the active medium and investigation of the pump source for a photochemical XeF (C-A) amplifier of femtosecond optical pulses显示文摘 | Malinovskii G Ya Mamaev S B Mikheev L D | 2001 | Quantum Electronics2001，31，7： | 1 |
| 6 | The human mitochondrial KATP channel is modulated by calcium and nitric oxide:a patch-clamp approach显示文摘 | Dahlem YA Horn TF Buntinas L | 2004 | Biochim Biophys Acta2004，1656，1： | 1 |
| 7 | Crystallization behavior of sprayformed and melt-spun A189La6Ni5 hybrid composites with amorphous and nanostructured phases显示文摘 | Ted Guo M L Tcao Chi YA | 2005 | Materials Science and Engineering A2005，404，： | 1 |
| 8 | Immune-mediated mechanisms of parasite tissuesequestration during experimental cerebral malaria显示文摘 | Amante FH Haque A Stanley AC Rivera Fde L Randall LM Wilson YA | 2010 | J Immu-nol2010，185，6： | 1 |
| 9 | A prospective, randomised study comparing the percutaneous compression plate and the com- pression hip screw for the treatment of intertrochanteric fractures of the hip显示文摘 | Peyser A Weil YA Brocke L | 2007 | J Bone Joint Surg Br2007，89，9： | 1 |
| 10 | Bayesian compressive sensing显示文摘 | Ji Shi-hao Xue Ya and Carin L | 2008 | IEEE Transactions on Signal Processing2008，56，6： | 1 |
| 11 | Structural diversity in Salmonella O antigens and its genetic basis显示文摘 | Liu B Knirel YA Feng L | 2014 | FEMS Microbiology Reviews2014，38，1： | 1 |
| 12 | Pentamidine- induced long QT syndrome and block of hERG trafficking 显示文摘 | KURSHEV YA FICKER E WANG L | 2005 | J Pharmacol Exp Ther2005，312，1： | 1 |
| 13 | A prospective, randomised study comparing the percutaneous compression plate and the compression hip screw for the treatment of intertrochanterie fractures of the hip 显示文摘 | Peyser A Weil YA Brooke L | 2007 | J Bone Joint Surg(Br)2007，89，9： | 1 |
| 14 | Bayesian Compressive Sensing显示文摘 | Ji Shihao Ya Xue Carin L | 2008 | IEEE Trans on Signal Process2008，56，6： | 1 |
| 15 | Development of automated online gel permeation chromatography-gas chromatograph mass spectrometry {or multiresidual pesticides in agricultural products 显示文摘 | Li B L Yuki Hashi Ya P Q | 2007 | Journal of Chromatography B2007，845，1： | 1 |
| 16 | Scaling of soil water retention using a fractal model 显示文摘 | Pachepsky Ya A Sncherbakov R A Korsunskaya L P | 1995 | Soil Sci1995，159，2： | 1 |
| 17 | TTP and TTT diagrams for quench sensitivity and ageing of 1424 alloy显示文摘 | DAVYDOV V G BER L B KAPUTKIN E YA | 2000 | Materials Science and Engineering A2000，280，1： | 1 |
| 18 | Heat- absorbing properties of explosion - suppressing powders显示文摘 | Datsenko D F Zabuga V Ya Dolinskaya L P | 1982 | Zhurnal Prildadnoi Khimii1982，55，3： | 1 |
| 19 | Biodiversity and fermentative activity of caecal microbial communities in wild and farm rabbits from Spain显示文摘 | Abecia L Rodríguez-Romero N Ya(n)ez-Ruiz D R | 2012 | Anaerobe2012，18，： | 1 |
| 20 | Growth of ZnO nanorods by aqueous solution method with eleetrodeposited ZnO seed layers 显示文摘 | Liu Z F E L Ya J | 2009 | Appl Surf Sci2009，255，12： | 1 |
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