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| 1 | Association between polymorphisms of APE1 and OGG1 and risk of colorectal cancer in Taiwan显示文摘AIM: To evaluate the effects of OGG1(Ser326Cys, 11657A/G, and Arg154His) and APE1(Asp148Glu, and T-656G) polymorphisms on colorectal cancer(CRC) risk.METHODS: We enrolled 727 cases newly diagnosed with colorectal adenocarcinoma and 736 age- and sex-matched healthy controls from a medical center in Taiwan. Genomic DNA isolated from the buffy coat was used for genotyping through polymerase chain reaction. Unconditional logistic regressions were used for calculating ORs and 95%CIs to determine the association between the genetic polymorphisms and CRC risk. Haplotype frequencies were estimated using PHASE software. Moreover, stratification analyses onthe basis of sex, age at diagnosis, and tumor subsite and stage were performed.RESULTS: The CRC risk was higher in patients with the OGG1 326Ser/Cys + Cys/Cys genotype(OR = 1.38, 95%CI: 1.03-1.85, P = 0.030), particularly high in patients with stage Ⅲ + Ⅳ cancer(OR = 1.48, 95%CI: 1.03-2.13) compared with patients with the Ser/Ser genotype. In addition, OGG1 11657 G allele carriers had a 41% reduced CRC risk among stage 0-Ⅱ patients(OR = 0.59, 95%CI: 0.35-0.98). The CRC risk was significantly higher among females with the APE1 Glu allele(OR = 1.41, 95%CI: 1.02-1.96). The APE1 148Glu/-656 G haplotype was also associated with a significant CRC risk in females(OR = 1.36, 95%CI: 1.03-1.78).CONCLUSION: OGG1 and APE1 polymorphisms are associated with stage- and sex-specific risk of CRC in the Taiwan Residents population. | Ching-Yu Lai Ling-Ling Hsieh Reiping Tang Regina M Santella Chung Rong Chang-Chieh Chih-Ching Yeh | 2016 | World Journal of Gastroenterology2016，22，12： | 7 |
| 2 | NKX6-1是胰腺及十二指肠神经内分泌肿瘤新的免疫组化标志物显示文摘Tseng I C, Yeh MM, YangCY, etal. NKX6-1 isanovelim- munohistochemical marker for pancreatic and duodenal neuroen- docrine tumors. Am J Surg Pathol, 2015,39(6) :850 -7.胃肠道神经内分泌肿瘤分为高分化神经内分泌肿瘤(WDNETs)及低分化神经内分泌癌(PDNECs),前者通常进行手术切除和(或)分子靶向治疗,而PDNECs通常采用化疗。NKX6-1是一种同源框转录因子,参与胰岛内分泌功能的发生和调节。 | Tseng I C Yeh M M Yang C Y 胡舜 余英豪 | 2015 | 临床与实验病理学杂志2015，31，8： | 5 |
| 3 | Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases显示文摘Hepatocyte nuclear factor 4-alpha(HNF4α)is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs(pancreas,stomach,and intestine).In liver,HNF4αis best known for its role as a master regulator of liver-specific gene expression and essential for adult and fetal liver function.Dysregulation of HNF4αexpression has been associated with many human diseases such as ulcerative colitis,colon cancer,maturity-onset diabetes of the young,liver cirrhosis,and hepatocellular carcinoma.However,the precise role of HNF4αin the etiology of these human pathogenesis is not well understood.Limited information is known about the role of HNF4αisoforms in liver and gastrointestinal disease progression.There is,therefore,a critical need to know how disruption of the expression of these isoforms may impact on disease progression and phenotypes.In this review,we will update our current understanding on the role of HNF4αin human liver and gastrointestinal diseases.We further provide additional information on possible use of HNF4αas a target for potential therapeutic approaches. | Matthew M Yeh Dustin E Bosch Sayed S Daoud | 2019 | World Journal of Gastroenterology2019，25，30： | 5 |
| 4 | Development of a Low-meltingpoint filler metal for brazing aluminium alloys显示文摘 | Chuang T H Yeh M S Tsao L C | 2000 | Metallurgial and Materials Transaetions A2000，31，9： | 2 |
| 5 | Deinterlacing by successive approximation显示文摘 | Kovacevic J Safrank R J Yeh E M | 1997 | IEEE Trans Image Processing1997，6，2： | 1 |
| 6 | Activation of CPP 32 -like pro tease in tumor necrosis factor - induced apoptosis is dependent on mitochondrial function显示文摘 | Higuchi M Aggarwal BB Yeh ET | 1997 | J Clin Invest1997，99，7： | 1 |
| 7 | Application of solidphase microextraction and gas chromatography-mass spectrometry for the determination of chlorophenols in urine显示文摘 | LEE M R YEH Y C HSIANG W S | 1998 | Chromatogr B Biomed Sci Appl1998，，707： | 1 |
| 8 | Robust control for linear systems with structural state space uncertainty显示文摘 | Banda S S Yeh H M | 1989 | Interna-tional Journal of Control1989，50，5： | 1 |
| 9 | A dinuclear Zn catalyst for the asymmetric nitroaldol (Henry) reaction显示文摘 | Trost B M Yeh V S C | 2002 | Angew Chem Int Ed2002，41，5： | 1 |
| 10 | Sweet potato (Ipomoea batatas) trypsin inhibitors expressed in transgenic tobacco plants confer resistance against Spodoptera litura显示文摘 | Yeh K W Lin M I Tuan S J etal | 1997 | Plant Cell Rep1997，16，： | 1 |
| 11 | Fatal hyperphosphatemia from a phosphosoda bowel preparation显示文摘 | Ullah N Yeh R Ehrinpreis M | 2002 | J Clin Gastroenterol2002，34，4： | 1 |
| 12 | Protective immunity against infectious bursal disease virus in chickens in the absence of virus-specific antibodies 显示文摘 | Yeh H Y Rautenschlein S Sharma J M | 2002 | Vet Immunol Immunopathol2002，89，34： | 1 |
| 13 | Isoflurane modulation of neuronal nicotinic acetylcholine receptors expressed in human embryonic kidney ceils 显示文摘 | Yamashita M Moil T Nagata K Yeh JZ Narahashi T | 2005 | Anesthesiology2005，102，1： | 1 |
| 14 | HER-2/neu expression as a predictor of response to neoadjuvant docetaxel in patients with operable breast carcinoma显示文摘 | Learn P A Yeh I T McNutt M | 2005 | Cancer2005，103，11： | 1 |
| 15 | Elucidation of the structure of cellulolytic enzyme lignin显示文摘 | Hu Z Yeh T F Chang H M | 2006 | Holzforschung2006，60，4： | 1 |
| 16 | Fabrication and mechanical properties of multi walled carbon nanotubes/epoxy nano composites 显示文摘 | Yeh M K Hsieh T H Tai N | 2008 | Mater Sci Eng A2008，483，484： | 1 |
| 17 | Stock assessment of the South Pacific albacore by using the generalized production model, 1967 - 1991 显示文摘 | YEH Y M WANG C H | 1996 | ACTA Oceanographica Taiwanica1996，，5： | 1 |
| 18 | Compressive loading at the end plate directly regulates flow and deformation of the basivertebral vein:an analytical study显示文摘 | Yeh M L Heggeness M H Chen H H | | 0，，： | 1 |
| 19 | The effects of inter-firm power and supply partner assessment on supply chain integra- tion显示文摘 | Pai F Y Yeh T M | 2010 | African Journal of Business Management2010，4，7： | 1 |
| 20 | Epidermal growth factor receptor inhibition by tyrphostin 51 induces apoptosis in luteinized granulosa cells 显示文摘 | Khan S M Oliver R H Yeh J | 2005 | J Clin Endocrinol Metab2005，90，1： | 1 |
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